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877676-50-1,MFCD16621126
Catalog No.:AA00H1GH

877676-50-1 | (7R)-2-Chloro-7-ethyl-7,8-dihydro-5-methyl-8-(1-methylethyl)-6(5h)-pteridinone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$29.00   $21.00
- +
1g
95%
in stock  
$95.00   $67.00
- +
5g
95%
in stock  
$273.00   $192.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00H1GH
Chemical Name:
(7R)-2-Chloro-7-ethyl-7,8-dihydro-5-methyl-8-(1-methylethyl)-6(5h)-pteridinone
CAS Number:
877676-50-1
Molecular Formula:
C12H17ClN4O
Molecular Weight:
268.7426
MDL Number:
MFCD16621126
SMILES:
CC[C@H]1N(C(C)C)c2nc(Cl)ncc2N(C1=O)C
Properties
Computed Properties
 
Complexity:
325  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.5  

Upstream Synthesis Route

[1]Patent:WO2007/90844,2007,A1,.Locationinpatent:Page/Pagecolumn14

[2]Patent:WO2009/19205,2009,A1,.Locationinpatent:Page/Pagecolumn14

[1]Patent:US2012/184543,2012,A1,

[2]Patent:EP2481739,2012,A1,

[3]Patent:EP2481739,2012,A1,.Locationinpatent:Page/Pagecolumn58

[4]Patent:US2012/184543,2012,A1,.Locationinpatent:Page/Pagecolumn59

[1]BioorganicandMedicinalChemistryLetters,2013,vol.23,#9,p.2743-2749

[1]JournalofMedicinalChemistry,2018,vol.61,#17,p.7785-7795

[1]JournalofMedicinalChemistry,2018,vol.61,#17,p.7785-7795

Downstream Synthesis Route
761440-78-2    877676-50-1   
(R)-7-ethyl-8-isopropyl-2-2-methoxy-4-(4-pyrrolidin-1-yl-piperidin-1-yl)-phenylamino-5-methyl-7,8-dihydro-5H-pteridin-6-one 

[1]Patent:US2006/46990,2006,A1.Locationinpatent:Page/Pagecolumn11

877676-50-1   
benzyl{3-4-(4-amino-3-methoxy-phenyl)-piperazin-1-yl-propyl}-carbamate 
 
benzyl(3-{4-4-((R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-pteridin-2-ylamino)-3-methoxy-phenyl-piperazin-1-yl}-propyl)-carbamate 

[1]Patent:US2006/46990,2006,A1.Locationinpatent:Page/Pagecolumn26

[1]Patent:WO2007/90844,2007,A1.Locationinpatent:Page/Pagecolumn14

[2]Patent:WO2009/19205,2009,A1.Locationinpatent:Page/Pagecolumn14

877676-50-1   
4-amino-N-(trans-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)-3-methoxybenzamide 
 
N-trans-4-4-(cyclopropylmethyl)-1-piperazinylcyclohexyl-4-(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)6-oxo-2-pteridinylamino-3-methoxy-benzamide 

[1]Patent:WO2007/90844,2007,A1.Locationinpatent:Page/Pagecolumn14-15

[2]Patent:WO2009/19205,2009,A1.Locationinpatent:Page/Pagecolumn14-15

[3]Patent:US2008/177066,2008,A1.Locationinpatent:Page/Pagecolumn67

[4]Patent:WO2012/49153,2012,A1.Locationinpatent:Page/Pagecolumn25;29-30

877676-50-1   
4-amino-N-(trans-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)-3-methoxybenzamide 
 
N-trans-4-4-(cyclopropylmethyl)-1-piperazinylcyclohexyl-4-(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinylamino-3-methoxy-benzamidetrihydrochloride 

[1]Patent:WO2007/90844,2007,A1.Locationinpatent:Page/Pagecolumn17

[2]Patent:WO2009/19205,2009,A1.Locationinpatent:Page/Pagecolumn17

Literature
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SDS
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Tags:877676-50-1 Molecular Formula|877676-50-1 MDL|877676-50-1 SMILES|877676-50-1 (7R)-2-Chloro-7-ethyl-7,8-dihydro-5-methyl-8-(1-methylethyl)-6(5h)-pteridinone