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75887-54-6,MFCD00869355
Catalog No.:AA008P1Q

75887-54-6 | Arteether

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5mg
95%
in stock  
$88.00   $62.00
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10mg
95%
in stock  
$140.00   $98.00
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25mg
≥97%
in stock  
$338.00   $237.00
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50mg
95%
in stock  
$489.00   $343.00
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100mg
95%
in stock  
$839.00   $587.00
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500mg
98%
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$2,939.00   $2,058.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008P1Q
Chemical Name:
Arteether
CAS Number:
75887-54-6
Molecular Formula:
C17H28O5
Molecular Weight:
312.4012
MDL Number:
MFCD00869355
SMILES:
CCO[C@H]1O[C@@H]2O[C@@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3
Properties
Computed Properties
 
Complexity:
443  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
2  
XLogP3:
3.4  

Literature

Title: Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system.

Journal: Toxicology and applied pharmacology 20140601

Title: Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents.

Journal: Journal of medicinal chemistry 20130110

Title: Bile acid-based 1,2,4-trioxanes: synthesis and antimalarial assessment.

Journal: Journal of medicinal chemistry 20121213

Title: Formulation design and in vivo antimalarial evaluation of lipid-based drug delivery systems for oral delivery of β-arteether.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120901

Title: Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice.

Journal: Experimental parasitology 20120701

Title: Linker-based hemisuccinate derivatives of artemisinin: synthesis and antimalarial assessment against multidrug-resistant Plasmodium yoelii nigeriensis in mice.

Journal: Journal of medicinal chemistry 20120209

Title: Curcumin-arteether combination therapy of Plasmodium berghei-infected mice prevents recrudescence through immunomodulation.

Journal: PloS one 20120101

Title: Plasmodium vinckei: infectivity of arteether-sensitive and arteether-resistant parasites in different strains of mice.

Journal: Parasitology research 20111001

Title: Neurological assessments after treatment with the antimalarial β-arteether in neonatal and adult rats.

Journal: Neurotoxicology 20110801

Title: A phase III clinical trial of alpha, beta-arteether injection 150 mg/ml in patients of P falciparum malaria.

Journal: Journal of the Indian Medical Association 20110801

Title: Preparation of molecularly imprinted polymers for artemisinin based on the surfaces of silica gel.

Journal: Journal of biotechnology 20110420

Title: Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and predict the neurotoxicity of artemisinins.

Journal: Toxicology 20110111

Title: Implication of intracellular glutathione and its related enzymes on resistance of malaria parasites to the antimalarial drug arteether.

Journal: Parasitology international 20110101

Title: Synthesis and antimalarial assessment of a new series of orally active amino-functionalized spiro 1,2,4-trioxanes.

Journal: Journal of medicinal chemistry 20101111

Title: Self-microemulsifiyng suppository formulation of β-artemether.

Journal: AAPS PharmSciTech 20100901

Title: 6-(4'-Aryloxy-phenyl)vinyl-1,2,4-trioxanes: a new series of orally active peroxides effective against multidrug-resistant Plasmodium yoelii in Swiss mice.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Toxicity of the antimalarial artemisinin and its dervatives.

Journal: Critical reviews in toxicology 20100501

Title: Efficacy of novel oral formulations of α/β arteether against multidrug-resistant malaria in mice.

Journal: Chemotherapy 20100101

Title: Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.

Journal: Journal of natural products 20090101

Title: alpha/beta-Arteether-induced mania in a predisposed adolescent.

Journal: General hospital psychiatry 20090101

Title: New functionalized 1,2,4-trioxepanes: synthesis and antimalarial activity against multi-drug resistant P. yoelii in mice.

Journal: Bioorganic & medicinal chemistry letters 20081001

Title: Developmental toxicity of artesunate in the rat: comparison to other artemisinins, comparison of embryotoxicity and kinetics by oral and intravenous routes, and relationship to maternal reticulocyte count.

Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20080801

Title: A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens.

Journal: Journal of pharmacokinetics and pharmacodynamics 20080401

Title: Distribution of C14-labelled arteether in kidneys and livers of experimental mice after intramuscular injection.

Journal: The Southeast Asian journal of tropical medicine and public health 20080301

Title: Orally active 1,2,4-trioxepanes: synthesis and antimalarial activity of a series of 7-arylvinyl-1,2,4-trioxepanes against multidrug-resistant Plasmodium yoelii in Swiss mice.

Journal: Bioorganic & medicinal chemistry 20080215

Title: Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice.

Journal: Bioorganic & medicinal chemistry letters 20080215

Title: Orally active antimalarials: synthesis and bioevaluation of a new series of steroid-based 1,2,4-trioxanes against multi-drug resistant malaria in mice.

Journal: Bioorganic & medicinal chemistry letters 20070801

Title: Efficacy of combined treatment with alpha/beta-arteether and sulfadoxine-pyrimethamine, for cases of Plasmodium falciparum malaria in Jharkhand, India.

Journal: Annals of tropical medicine and parasitology 20070401

Title: New adamantane-based spiro 1,2,4-trioxanes orally effective against rodent and simian malaria.

Journal: Journal of medicinal chemistry 20070208

Title: Quality control of active ingredients in artemisinin-derivative antimalarials within Kenya and DR Congo.

Journal: Tropical medicine & international health : TM & IH 20070101

Title: New orally active derivatives of artemisinin with high efficacy against multidrug-resistant malaria in mice.

Journal: Journal of medicinal chemistry 20061130

Title: Reactions of artemisinin and arteether with acid: implications for stability and mode of antimalarial action.

Journal: Journal of medicinal chemistry 20061005

Title: Plasmodium vinckei: selection of a strain exhibiting stable resistance to arteether.

Journal: Experimental parasitology 20061001

Title: Simultaneous quantification of alpha-/beta-diastereomers of arteether, sulphadoxine and pyrimethamine: a promising anti-relapse antimalarial therapeutic combination, by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060914

Title: Efficacy and safety of beta-arteether and alpha/beta-arteether for treatment of acute Plasmodium falciparum malaria.

Journal: The American journal of tropical medicine and hygiene 20060701

Title: Malaria: severe, life threatening.

Journal: Clinical evidence 20060601

Title: Orally active 1,2,4-trioxanes: synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant plasmodium yoelii nigeriensis in mice.

Journal: Journal of medicinal chemistry 20060504

Title: Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: Effects of artemisinin, artemether, and arteether on the pharmacokinetics of phenytoin.

Journal: Methods and findings in experimental and clinical pharmacology 20060301

Title: Effects of artemisinin, artemether, arteether on the pharmacokinetics of carbamazepine.

Journal: Pharmacology 20060101

Title: Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives.

Journal: Journal of medicinal chemistry 20051006

Title: Pharmacokinetics of the diastereomers of arteether, a potent antimalarial drug, in rats.

Journal: Biopharmaceutics & drug disposition 20050901

Title: Blood schizontocidal activity of azithromycin and its combination with alpha/beta arteether against multi-drug resistant Plasmodium yoelii nigeriensis, a novel MDR parasite model for antimalarial screening.

Journal: Parasitology 20050901

Title: Antifungal activity of artemisinin derivatives.

Journal: Journal of natural products 20050801

Title: Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate.

Journal: Chembiochem : a European journal of chemical biology 20050401

Title: Studies on drug metabolizing enzymes during arteether treatment of Plasmodium yoelii nigeriensis infected mice cerebral microvessels.

Journal: The Journal of communicable diseases 20050301

Title: Clinical pharmacokinetics of the diastereomers of arteether in healthy volunteers.

Journal: Clinical pharmacokinetics 20050101

Title: Pharmacokinetic investigation on the therapeutic potential of artemotil (beta-arteether) in Thai patients with severe Plasmodium falciparum malaria.

Journal: The American journal of tropical medicine and hygiene 20041201

Title: Intramuscular arteether for treating severe malaria.

Journal: The Cochrane database of systematic reviews 20041018

Title: [Combined antimalarial therapy using artemisinin].

Journal: Parassitologia 20040601

Title: Efficacy of arteether in chloroquine resistant falciparum malaria in eastern India.

Journal: The Indian journal of medical research 20040101

Title: Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells.

Journal: Bioorganic & medicinal chemistry letters 20031103

Title: An HPLC-MS method for simultaneous estimation of alpha,beta-arteether and its metabolite dihydroartemisinin, in rat plasma for application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20031001

Title: Densitometric thin-layer chromatographic determination of artemisinin and its lipophilic derivatives, artemether and arteether.

Journal: Journal of chromatographic science 20030801

Title: Neuropathological assessment of artemether-treated severe malaria.

Journal: Lancet (London, England) 20030726

Title: A sensitive and selective liquid chromatographic/electrospray ionization tandem mass spectrometric assay for the simultaneous quantification of alpha-,beta-arteether and its metabolite dihydroartemisinin in plasma, useful for pharmacokinetic studies.

Journal: Journal of mass spectrometry : JMS 20030701

Title: A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.

Journal: Journal of medicinal chemistry 20030605

Title: [Three newly registered drugs in the Netherlands for the treatment and chemoprophylaxis of malaria: atovaquone-proguanil, artemether-lumefantrine and artemotil].

Journal: Nederlands tijdschrift voor geneeskunde 20030215

Title: Liquid chromatographic-mass spectrometric method for the determination of alpha-,beta-arteether in rat serum.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030115

Title: Synthesis, stability, and antimalarial activity of new hydrolytically stable and water-soluble (+)-deoxoartelinic acid.

Journal: Journal of medicinal chemistry 20021024

Title: mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether.

Journal: Biochemical pharmacology 20020815

Title: Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity.

Journal: Journal of medicinal chemistry 20020801

Title: Efficacy of alpha, beta - Arteether in children with cerebral malaria in forested tribal belt.

Journal: Indian pediatrics 20020601

Title: Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria.

Journal: British journal of clinical pharmacology 20020501

Title: Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents.

Journal: The American journal of tropical medicine and hygiene 20020501

Title: Artemotil Artecef.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020401

Title: Post-marketing surveillance of arteether in malaria.

Journal: The Journal of the Association of Physicians of India 20020401

Title: Multicentric clinical trials for safety and efficacy evaluation of alpha;beta arteether in complicated P. falciparum malaria.

Journal: The Journal of the Association of Physicians of India 20011201

Title: Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.

Journal: Journal of medicinal chemistry 20010913

Title: Arteether in therapy of malaria.

Journal: The Journal of the Association of Physicians of India 20010701

Title: A multicentric study with arteether in patients of uncomplicated falciparum malaria.

Journal: The Journal of the Association of Physicians of India 20010701

Title: Effect of beta-arteether treatment on erythrocytic methemoglobin reductase system in Plasmodium yoelii nigeriensis infected mice.

Journal: Drug and chemical toxicology 20010501

Title: Effects of arteether on an auditory radial-arm maze task in rats.

Journal: Physiology & behavior 20010501

Title: Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde, Cameroon.

Journal: The American journal of tropical medicine and hygiene 20010101

Title: Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.

Journal: The American journal of tropical medicine and hygiene 19930301

Title: Shmuklarsky MJ, et al. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. Am J Trop Med Hyg. 1993 Mar;48(3):377-84.

Title: Li QG, et al. Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):213-23.

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