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76-78-8,MFCD00273126
Catalog No.:AA00G2PF

76-78-8 | QUASSIN

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Purity
Availability
Price(USD)
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1mg
≥98%
in stock  
$122.00   $85.00
- +
5mg
≥98%
in stock  
$455.00   $318.00
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10mg
≥98%
in stock  
$668.00   $467.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G2PF
Chemical Name:
QUASSIN
CAS Number:
76-78-8
Molecular Formula:
C22H28O6
Molecular Weight:
388.4541
MDL Number:
MFCD00273126
SMILES:
COC1=CC(C)C2C(C1=O)(C)C1C(=O)C(=C(C3C1(C(C2)OC(=O)C3)C)C)OC
Properties
Computed Properties
 
Complexity:
838  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
2  
XLogP3:
2.4  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin.

Journal: Experimental parasitology 20100401

Title: Liquid chromatography electrospray ionization tandem mass spectrometric determination of quassin and neoquassin in fruits and vegetables.

Journal: Journal of agricultural and food chemistry 20100310

Title: Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.

Journal: Journal of natural products 20090327

Title: Inhibition of CYP1A1 by Quassinoids found in Picrasma excelsa.

Journal: Planta medica 20090201

Title: Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity.

Journal: The Journal of antimicrobial chemotherapy 20090201

Title: Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.

Journal: International journal of toxicology 20080101

Title: [Analysis of constituents in Jamaica quassia extract, a natural bittering agent].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20031201

Title: Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactone.

Journal: Journal of natural products 20031101

Title: Antiviral activity of simalikalactone D, a quassinoid from Quassia africana.

Journal: Planta medica 20020101

Title: Anti-tuberculosis activity of quassinoids.

Journal: Chemical & pharmaceutical bulletin 19970901

Title: Raji Y, et al. Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara. Niger J Physiol Sci. 2010 Nov 24;25(2):95-102.

Title: Mishra K, et al. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin. Exp Parasitol. 2010 Apr;124(4):421-7.

Title: Njar VC, et al. Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro. Planta Med. 1995 Apr;61(2):180-2.

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