Title: Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20181001
Title: Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180701
Title: The CAR agonist TCPOBOP inhibits lipogenesis and promotes fibrosis in the mammary gland of adolescent female mice.
Journal: Toxicology letters 20180615
Title: Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180401
Title: Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR.
Journal: The Journal of toxicological sciences 20180101
Title: Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170901
Title: Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20161001
Title: Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20161001
Title: Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.
Journal: Biochimica et biophysica acta 20160901
Title: Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes.
Journal: The Journal of pharmacology and experimental therapeutics 20160801
Title: Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Journal: Toxicology and applied pharmacology 20160715
Title: Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160601
Title: Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation.
Journal: Nuclear receptor research 20160101
Title: A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.
Journal: Archives of toxicology 20151201
Title: Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators.
Journal: Journal of biochemical and molecular toxicology 20151201
Title: Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20151001
Title: Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver.
Journal: Toxicology and applied pharmacology 20151001
Title: Improved assays for xenosensor activation based on reverse transfection.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151001
Title: Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.
Journal: The Journal of biological chemistry 20150320
Title: Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.
Journal: Archives of toxicology 20150101
Title: Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.
Journal: Nuclear receptor signaling 20150101
Title: Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.
Journal: Toxicology and applied pharmacology 20140815
Title: Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action.
Journal: Toxicology 20140703
Title: CAR-mediated repression of Foxo1 transcriptional activity regulates the cell cycle inhibitor p21 in mouse livers.
Journal: Toxicology 20140703
Title: Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.
Journal: PloS one 20140101
Title: The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers.
Journal: Toxicology and applied pharmacology 20131001
Title: Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20131001
Title: Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ERα in mouse livers.
Journal: Toxicology and applied pharmacology 20130901
Title: Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130901
Title: The time point of β-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor.
Journal: Toxicology 20130607
Title: p38 Mitogen-activated protein kinase regulates nuclear receptor CAR that activates the CYP2B6 gene.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20130601
Title: Induction of xenobiotic receptors, transporters, and drug metabolizing enzymes by oxycodone.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20130501
Title: Expression of human CAR splicing variants in BAC-transgenic mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130301
Title: Quantitative analysis of the interaction of constitutive androstane receptor with chemicals and steroid receptor coactivator 1 using surface plasmon resonance biosensor systems: a case study of the Baikal seal (Pusa sibirica) and the mouse.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130101
Title: Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
Journal: PloS one 20130101
Title: Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver.
Journal: Hepatology (Baltimore, Md.) 20121001
Title: Hormonal and chemical regulation of paraoxonases in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20120901
Title: Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR.
Journal: Toxicology letters 20120803
Title: Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice.
Journal: American journal of physiology. Endocrinology and metabolism 20120715
Title: Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120701
Title: Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120601
Title: 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene induces substantial hyperplasia in fibrotic mouse liver.
Journal: International journal of experimental pathology 20120401
Title: Characterization of human cytochrome P450 induction by pesticides.
Journal: Toxicology 20120329
Title: Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120201
Title: Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase.
Journal: Toxicology letters 20120125
Title: Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line.
Journal: Biochemical pharmacology 20120115
Title: Treatment with a constitutive androstane receptor ligand ameliorates the signs of preeclampsia in high-fat diet-induced obese pregnant mice.
Journal: Molecular and cellular endocrinology 20120102
Title: SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism.
Journal: Journal of hepatology 20120101
Title: Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101
Title: Effect of lipopolysaccharide on the xenobiotic-induced expression and activity of hepatic cytochrome P450 in mice.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha.
Journal: PloS one 20120101
Title: Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3.
Journal: Journal of hepatology 20111101
Title: Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.
Journal: The Journal of pharmacology and experimental therapeutics 20111101
Title: Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice.
Journal: The Journal of clinical investigation 20111101
Title: Potential role of estradiol and progesterone in insulin resistance through constitutive androstane receptor.
Journal: Journal of molecular endocrinology 20111001
Title: Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20111001
Title: Multi-species analyses of direct activators of the constitutive androstane receptor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111001
Title: Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110901
Title: The nuclear receptor CAR modulates alcohol-induced liver injury.
Journal: Laboratory investigation; a journal of technical methods and pathology 20110801
Title: Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice.
Journal: Hepatology (Baltimore, Md.) 20110801
Title: Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice.
Journal: Journal of hepatology 20110701
Title: Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.
Journal: Hepatology (Baltimore, Md.) 20110601
Title: Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor.
Journal: Molecular pharmacology 20110601
Title: Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.
Journal: International journal of oncology 20110601
Title: Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Journal: Drug metabolism reviews 20110501
Title: Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
Journal: Carcinogenesis 20110401
Title: Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells.
Journal: British journal of cancer 20110201
Title: Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.
Journal: Hepatology (Baltimore, Md.) 20110201
Title: AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids.
Journal: The Journal of biological chemistry 20110128
Title: Helix 11 dynamics is critical for constitutive androstane receptor activity.
Journal: Structure (London, England : 1993) 20110112
Title: Antiepileptic drugs reduce the efficacy of methotrexate chemotherapy through accelerated degradation of the reduced folate carrier by the ubiquitin-proteasome pathway.
Journal: Chemotherapy 20110101
Title: Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells.
Journal: Experimental & molecular medicine 20101130
Title: The primary mitogen (TCPOBOP)-induced hepatocyte proliferation is resistant to transforming growth factor- β-1 inhibition.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20101101
Title: The activated aryl hydrocarbon receptor synergizes mitogen-induced murine liver hyperplasia.
Journal: Toxicology 20101009
Title: Polybrominated diphenyl ethers and arylhydrocarbon receptor agonists: Different toxicity and target gene expression.
Journal: Toxicology letters 20101005
Title: A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses.
Journal: Molecular pharmacology 20101001
Title: Transient disruption of liver gap junctional intercellular communication and induction of apoptosis after administration of 1,4-bis[2-(3,5 dichloropyridyloxy)]benzene in mice.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20100901
Title: Histone deacetylase inhibitors induce cytochrome P450 2B by activating nuclear receptor constitutive androstane receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100901
Title: Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.
Journal: Molecular pharmacology 20100901
Title: The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701
Title: Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
Journal: Toxicology and applied pharmacology 20100615
Title: Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).
Journal: Endocrinology 20100401
Title: Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.
Journal: Carcinogenesis 20100201
Title: Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.
Journal: Biochemical pharmacology 20100115
Title: Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100101
Title: PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex.
Journal: PPAR research 20100101
Title: Species-specific induction of CYP2B by 2,4,6-tryphenyldioxane-1,3 (TPD).
Journal: Life sciences 20091216
Title: Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia.
Journal: World journal of gastroenterology 20091114
Title: The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity.
Journal: The Journal of biological chemistry 20090918
Title: Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Journal: Toxicology letters 20090710
Title: Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090701
Title: Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501
Title: Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501
Title: Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401
Title: The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress.
Journal: Journal of lipid research 20090301
Title: Toxicogenomic biomarkers for liver toxicity.
Journal: Journal of toxicologic pathology 20090301
Title: Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).
Journal: Toxicology 20090204
Title: A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090101
Title: Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090101
Title: Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.
Journal: BMC genomics 20090101
Title: Suitable reference genes for the analysis of direct hyperplasia in mice.
Journal: Biochemical and biophysical research communications 20081226
Title: Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.
Journal: Archives of toxicology 20081201
Title: Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081201
Title: Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
Journal: Journal of medicinal chemistry 20081127
Title: Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice.
Journal: Toxicology and applied pharmacology 20081015
Title: C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.
Journal: Hepatology (Baltimore, Md.) 20081001
Title: Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice.
Journal: Journal of lipid research 20080801
Title: The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080701
Title: Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080501
Title: Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation.
Journal: Laboratory investigation; a journal of technical methods and pathology 20080401
Title: Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080301
Title: Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201
Title: Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080101
Title: Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT.
Journal: BMC genomics 20080101
Title: Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
Journal: The Journal of biological chemistry 20071214
Title: Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse.
Journal: World journal of gastroenterology 20071114
Title: Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071001
Title: The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070801
Title: Downregulation of the reduced folate carrier transport activity by phenobarbital-type cytochrome P450 inducers and protein kinase C activators.
Journal: Biochimica et biophysica acta 20070601
Title: Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes.
Journal: Molecular pharmacology 20070501
Title: Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20070201
Title: Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry.
Journal: Biochemistry 20070123
Title: Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.
Journal: Oncogene 20070111
Title: Comparative study of CYP2B induction in the liver of rats and mice by different compounds.
Journal: Life sciences 20070102
Title: In silico prediction of pregnane X receptor activators by machine learning approaches.
Journal: Molecular pharmacology 20070101
Title: Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal: molecular characterization, expression level, and ligand profiling in Baikal seal (Pusa sibirica).
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20061101
Title: Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics.
Journal: The Biochemical journal 20060815
Title: Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
Journal: Hepatology (Baltimore, Md.) 20060701
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor.
Journal: Molecular pharmacology 20060401
Title: Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver.
Journal: Molecular pharmaceutics 20060101
Title: Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia.
Journal: Hepatology (Baltimore, Md.) 20051101
Title: Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.
Journal: Molecular endocrinology (Baltimore, Md.) 20050901
Title: Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050901
Title: Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20050830
Title: CAR and PXR: xenosensors of endocrine disrupters?
Journal: Chemico-biological interactions 20050815
Title: CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.
Journal: Hepatology (Baltimore, Md.) 20050801
Title: Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor.
Journal: Molecular endocrinology (Baltimore, Md.) 20050701
Title: Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050701
Title: Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050701
Title: Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.
Journal: The Biochemical journal 20050601
Title: Induction of pancreatic acinar cell proliferation by thyroid hormone.
Journal: The Journal of endocrinology 20050601
Title: Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool.
Journal: The American journal of pathology 20050401
Title: Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.
Journal: Endocrinology 20050301
Title: Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells.
Journal: The Journal of biological chemistry 20050204
Title: Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.
Journal: Archives of biochemistry and biophysics 20050201
Title: Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.
Journal: Molecular endocrinology (Baltimore, Md.) 20041001
Title: Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP.
Journal: Hepatology (Baltimore, Md.) 20041001
Title: The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.
Journal: The Journal of biological chemistry 20040507
Title: A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.
Journal: Molecular pharmacology 20040201
Title: Dual action of oestrogens on the mouse constitutive androstane receptor.
Journal: The Biochemical journal 20031201
Title: Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.
Journal: The Journal of biological chemistry 20031114
Title: A common set of immediate-early response genes in liver regeneration and hyperplasia.
Journal: Hepatology (Baltimore, Md.) 20030801
Title: Sex difference in the proliferative response of mouse hepatocytes to treatment with the CAR ligand, TCPOBOP.
Journal: Carcinogenesis 20030601
Title: The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor.
Journal: Molecular endocrinology (Baltimore, Md.) 20030201
Title: Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli.
Journal: Hepatology (Baltimore, Md.) 20021101
Title: Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.
Journal: Science (New York, N.Y.) 20021011
Title: Insights from a three-dimensional model into ligand binding to constitutive active receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020901
Title: Inducer effect on the complex formation between rat liver nuclear proteins and cytochrome P450 2B gene regulatory elements.
Journal: Biochemistry. Biokhimiia 20020901
Title: Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020801
Title: Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis.
Journal: Pharmacology & toxicology 20020701
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops).
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020401
Title: Role of hepatocyte direct hyperplasia in lentivirus-mediated liver transduction in vivo.
Journal: Human gene therapy 20020320
Title: Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201
Title: The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201
Title: Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response.
Journal: The pharmacogenomics journal 20020101
Title: Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.
Journal: Molecular endocrinology (Baltimore, Md.) 20010901
Title: Peroxisome proliferator-activated receptor-alpha mice show enhanced hepatocyte proliferation in response to the hepatomitogen 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene, a ligand of constitutive androstane receptor.
Journal: Hepatology (Baltimore, Md.) 20010801
Title: A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).
Journal: Pharmaceutical research 20010201
Title: Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.
Journal: Molecular endocrinology (Baltimore, Md.) 20001101
Title: The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR.
Journal: Molecular and cellular biology 20000501
Title: Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
Journal: Carcinogenesis 19850201
Title: Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718.
Title: Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.
