Home Other Building Blocks 77191-36-7
77191-36-7,MFCD00209882
Catalog No.:AA008NJM

77191-36-7 | Nefiracetam

Pack Size
Purity
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Price(USD)
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1mg
97%
in stock  
$7.00   $5.00
- +
50mg
97%
in stock  
$21.00   $15.00
- +
100mg
97%
in stock  
$32.00   $22.00
- +
250mg
97%
in stock  
$53.00   $37.00
- +
1g
97%
in stock  
$77.00   $54.00
- +
5g
97%
in stock  
$233.00   $164.00
- +
10g
98%
in stock  
$427.00   $299.00
- +
25g
97%
in stock  
$701.00   $491.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008NJM
Chemical Name:
Nefiracetam
CAS Number:
77191-36-7
Molecular Formula:
C14H18N2O2
Molecular Weight:
246.3049
MDL Number:
MFCD00209882
SMILES:
O=C(Nc1c(C)cccc1C)CN1CCCC1=O
NSC Number:
759830
Properties
Computed Properties
 
Complexity:
320  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.4  

Literature

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Journal: PloS one 20110101

Title: Age sensitivity of behavioral tests and brain substrates of normal aging in mice.

Journal: Frontiers in aging neuroscience 20110101

Title: Pharmacological study on Alzheimer's drugs targeting calcium/calmodulin-dependent protein kinase II.

Journal: Journal of pharmacological sciences 20110101

Title: Synthesis of N-substituted Clausenamide analogues.

Journal: European journal of medicinal chemistry 20101101

Title: Apathy following stroke.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20100601

Title: Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders.

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Title: Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function.

Journal: PloS one 20100101

Title: Trace eyeblink conditioning is impaired in α7 but not in β2 nicotinic acetylcholine receptor knockout mice.

Journal: Frontiers in behavioral neuroscience 20100101

Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice.

Journal: Journal of neurochemistry 20090701

Title: Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.

Journal: Neuroscience 20090505

Title: Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice.

Journal: Brain research 20090410

Title: Double-blind treatment of apathy in patients with poststroke depression using nefiracetam.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20090101

Title: CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region.

Journal: Journal of neurochemistry 20080801

Title: Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain.

Journal: Bioorganic & medicinal chemistry 20080315

Title: Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity.

Journal: Molecular pain 20080101

Title: Double-blind randomized treatment of poststroke depression using nefiracetam.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20080101

Title: Nefiracetam potentiates N-methyl-D-aspartate (NMDA) receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor.

Journal: Molecular pharmacology 20070201

Title: Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds.

Journal: Behavioural brain research 20061002

Title: Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060101

Title: Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: Effects of Nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats.

Journal: Epilepsia 20051001

Title: Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats.

Journal: Brain research 20050928

Title: Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetam.

Journal: Archives of toxicology 20050901

Title: [Evaluation methods for the discriminative stimulus and possible mechanisms of discriminative stimulus effects of methamphetamine in the rat].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20050701

Title: Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats.

Journal: Epilepsia 20050601

Title: Effects of nefiracetam on the levels of brain-derived neurotrophic factor and synapsin I mRNA and protein in the hippocampus of microsphere-embolized rats.

Journal: European journal of pharmacology 20050110

Title: Pre-injury administration of morphine prevents development of neuropathic hyperalgesia through activation of descending monoaminergic mechanisms in the spinal cord in mice.

Journal: Molecular pain 20050101

Title: Early pathophysiological features in canine renal papillary necrosis induced by nefiracetam.

Journal: Toxicologic pathology 20050101

Title: Mechanisms of action of cognitive enhancers on neuroreceptors.

Journal: Biological & pharmaceutical bulletin 20041101

Title: Nootropic nefiracetam inhibits proconvulsant action of peripheral-type benzodiazepines in epileptic mutant EL mice.

Journal: Annals of the New York Academy of Sciences 20041001

Title: Nefiracetam attenuates methamphetamine-induced discriminative stimulus effects in rats.

Journal: Annals of the New York Academy of Sciences 20041001

Title: Negative regulation of opioid receptor-G protein-Ca2+ channel pathway by the nootropic nefiracetam.

Journal: Annals of the New York Academy of Sciences 20041001

Title: Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits.

Journal: Neurobiology of aging 20040701

Title: Testicular toxicity induced in dogs by nefiracetam, a neutrotransmission enhancer.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20040501

Title: The cognition-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors.

Journal: Life sciences 20031205

Title: Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20031001

Title: Investigation of testicular toxicity of nefiracetam, a neurotransmission enhancer, in rats.

Journal: Toxicology letters 20030828

Title: Comprehensive evaluation of canine renal papillary necrosis induced by nefiracetam, a neurotransmission enhancer.

Journal: European journal of pharmacology 20030815

Title: Effect of nefiracetam, a neurotransmission enhancer, on primary uroepithelial cells of the canine urinary bladder.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030301

Title: Effects of nefiracetam on cerebral adenylyl cyclase activity in rats with microsphere embolism-induced memory dysfunction.

Journal: Biological & pharmaceutical bulletin 20030301

Title: Persistent effects of delayed treatment with nefiracetam on the water maze task in rats with sustained cerebral ischemia.

Journal: The Journal of pharmacology and experimental therapeutics 20030201

Title: A possible mechanism for improvement by a cognition-enhancer nefiracetam of spatial memory function and cAMP-mediated signal transduction system in sustained cerebral ischaemia in rats.

Journal: British journal of pharmacology 20030201

Title: Nefiracetam induces a long-lasting facilitation of hippocampal postsynaptic responses in mice lacking the NMDA receptor epsilon1 subunit.

Journal: Brain research 20021122

Title: Effects of nefiracetam on spatial memory function and acetylcholine and GABA metabolism in microsphere-embolized rats.

Journal: European journal of pharmacology 20021018

Title: The long-term effects of nefiracetam on learning in older rabbits.

Journal: Behavioural brain research 20021017

Title: Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Impairment of contextual fear conditioning in rats by Group I mGluRs: reversal by the nootropic nefiracetam.

Journal: Pharmacology, biochemistry, and behavior 20020901

Title: No spatial working memory deficit in beta-amyloid-exposed rats. A longitudinal study.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020601

Title: Nefiracetam. Daiichi Seiyaku.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Nefiracetam ameliorates associative learning impairment in the scopolamine-injected older rabbit.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20020401

Title: The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition.

Journal: Neurochemistry international 20020201

Title: Nefiracetam improves the impairment of local cerebral blood flow and glucose utilization after chronic focal cerebral ischemia in rats.

Journal: Pharmacology 20020101

Title: Nefiracetam. DM 9384, DZL 221, Translon.

Journal: Drugs in R&D 20020101

Title: The protective action of nefiracetam against electrophysiological and metabolic damage in the hippocampus after deprivation of glucose and oxygen.

Journal: Brain research 20011213

Title: Nefiracetam metabolism by human liver microsomes: role of cytochrome P450 3A4 and cytochrome P450 1A2 in 5-hydroxynefiracetam formation.

Journal: The Journal of pharmacy and pharmacology 20010601

Title: Post-stroke dementia. Nootropic drug modulation of neuronal nicotinic acetylcholine receptors.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.

Journal: Molecular pharmacology 20010401

Title: Nefiracetam improves Morris water maze performance following traumatic brain injury in rats.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: Basic science and epilepsy: experimental epilepsy surgery.

Journal: Stereotactic and functional neurosurgery 20010101

Title: Quantitative effects of nefiracetam on spatial learning of rats after cerebral embolism.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20010101

Title: Nefiracetam prevents propofol-induced anterograde and retrograde amnesia in the rodent without compromising quality of anesthesia.

Journal: Anesthesiology 19980901

Title: Nefiracetam (DM-9384) reverses apomorphine-induced amnesia of a passive avoidance response: delayed emergence of the memory retention effects.

Journal: Neurochemical research 19960601

Title: Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice.

Journal: Pharmacology, biochemistry, and behavior 19900601

Title: Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats.

Journal: Japanese journal of pharmacology 19890501

Title: Nishizaki, T., et al., Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways. Mol Pharmacol, 1998. 53(1): p. 1-5.

Title: Shiotani, T., et al., Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res, 2000. 859(2): p. 255-61.

Title: Sakurai, T., et al., Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384) on learning and memory in rats. Jpn J Pharmacol, 1989. 50(1): p. 47-53.

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