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Home Other Building Blocks 774-52-7
774-52-7,MFCD00460869
Catalog No.:AA005B7B

774-52-7 | 1-Methyl-4-phenylpiperidine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$203.00   $142.00
- +
1g
95%
in stock  
$525.00   $368.00
- +
5g
98%
in stock  
$1,640.00   $1,148.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA005B7B
Chemical Name:
1-Methyl-4-phenylpiperidine
CAS Number:
774-52-7
Molecular Formula:
C12H17N
Molecular Weight:
175.2701
MDL Number:
MFCD00460869
SMILES:
CN1CCC(CC1)c1ccccc1
Properties
Properties
 
BP:
254°C at 760 mmHg  
Form:
Liquid  
MP:
9°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
141  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2.5  

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1943,vol.65,p.2458

[1]JournalofMedicinalChemistry,1989,vol.32,p.1217-1230

[2]Patent:CN106146493,2016,A.Locationinpatent:Paragraph0438;0439;0440;0441

[3]MagneticResonanceinChemistry,2007,vol.45,p.749-757

[4]Patent:WO2006/12374,2006,A1.Locationinpatent:Page/Pagecolumn173

[5]Patent:US2003/225106,2003,A1.Locationinpatent:Page61;83-84

[6]BioorganicandMedicinalChemistry,2010,vol.18,p.4111-4118

[7]Patent:WO2005/120509,2005,A1.Locationinpatent:Page/Pagecolumn72

[1]CurrentPatentAssignee:VIVORYONTHERAPEUTICSAG-US2011/92501,2011,A1

Literature

Title: Uncoupling of ATP-depletion and cell death in human dopaminergic neurons.

Journal: Neurotoxicology 20120801

Title: Effect of chronic L-dopa or melatonin treatments after dopamine deafferentation in rats: dyskinesia, motor performance, and cytological analysis.

Journal: ISRN neurology 20120101

Title: Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B.

Journal: Bioorganic & medicinal chemistry 20100601

Title: Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours.

Journal: Human molecular genetics 20100215

Title: Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.

Journal: Journal of medicinal chemistry 20080925

Title: Inclusion dynamics in PC12 is comparable between amphetamines and MPTP.

Journal: Annals of the New York Academy of Sciences 20060801

Title: Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells.

Journal: Cell biology international 20051001

Title: Targeting JNK3 for the treatment of neurodegenerative disorders.

Journal: Drug discovery today 20041101

Title: Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

Journal: The Journal of biological chemistry 20010706

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SDS
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