Home Other Building Blocks 778270-11-4
778270-11-4,MFCD09265253
Catalog No.:AA00G3LM

778270-11-4 | Gnf-2

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$133.00   $93.00
- +
5mg
≥98%
in stock  
$193.00   $135.00
- +
10mg
≥98%
in stock  
$329.00   $230.00
- +
25mg
≥98%
in stock  
$670.00   $469.00
- +
50mg
≥98%
in stock  
$912.00   $638.00
- +
250mg
≥98%
in stock  
$3,997.00   $2,798.00
- +
500mg
98% by HPLC
in stock  
$7,073.00   $4,951.00
- +
1000mg
98% by HPLC
in stock  
$11,279.00   $7,896.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G3LM
Chemical Name:
Gnf-2
CAS Number:
778270-11-4
Molecular Formula:
C18H13F3N4O2
Molecular Weight:
374.3166
MDL Number:
MFCD09265253
SMILES:
NC(=O)c1cccc(c1)c1ncnc(c1)Nc1ccc(cc1)OC(F)(F)F
Properties
Computed Properties
 
Complexity:
498  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.8  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Expanding the diversity of allosteric bcr-abl inhibitors.

Journal: Journal of medicinal chemistry 20101014

Title: Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms.

Journal: Bioorganic & medicinal chemistry 20100601

Title: Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.

Journal: Nature 20100128

Title: A new screening assay for allosteric inhibitors of cSrc.

Journal: Nature chemical biology 20090601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Allosteric inhibitors of Bcr-abl-dependent cell proliferation.

Journal: Nature chemical biology 20060201

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