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Home Fluorides 784-57-6
784-57-6,MFCD00042160
Catalog No.:AA003EUJ

784-57-6 | 2-Morpholino-5-(trifluoromethyl)aniline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
97%
in stock  
$25.00   $18.00
- +
1g
97%
in stock  
$46.00   $32.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003EUJ
Chemical Name:
2-Morpholino-5-(trifluoromethyl)aniline
CAS Number:
784-57-6
Molecular Formula:
C11H13F3N2O
Molecular Weight:
246.2289
MDL Number:
MFCD00042160
SMILES:
Nc1cc(ccc1N1CCOCC1)C(F)(F)F
Properties
Properties
 
BP:
348.5 °C at 760 mmHg  
Form:
Solid  
MP:
127-128°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
254  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.9  

Downstream Synthesis Route

[1]Siqueira,RaoniPais;Barros,MarcusViníciusdeAndrade;Barbosa,ÉvertondeAlmeidaAlves;Onofre,ThiagoSouza;Gonçalves,VictorHugoSousa;Pereira,HigorSette;SilvaJúnior,Abelardo;deOliveira,LeandroLicursi;Almeida,MárciaRogéria;Fietto,JulianaLopesRangel;Teixeira,RóbsonRicardo;Bressan,GustavoCosta[EuropeanJournalofMedicinalChemistry,2017,vol.134,p.97-109]

[2]CurrentPatentAssignee:HAGIWARA(inventors)-EP1712242,2006,A1Locationinpatent:Page/Pagecolumn35

[3]CurrentPatentAssignee:NANKAIUNIVERSITY-CN113024538,2021,ALocationinpatent:Paragraph0035;0057-0058

[4]Nishinoetal.[KogyoKagakuzasshi/JournaloftheSocietyofChemicalIndustry,1959,vol.62,p.706,708][ChemischesZentralblatt,1960,vol.131,p.7854]

[5]CurrentPatentAssignee:RIOTINTOGROUP;YUNAITETSUDOSUTEETSUBORATSUKUSUANDOCHEM-US4049422,1977,A

[6]CurrentPatentAssignee:RIOTINTOGROUP-US4133672,1979,A

[7]Bailey,BrodieL.;Nguyen,William;Ngo,Anna;Goodman,ChristopherD.;Gancheva,MariaR.;Favuzza,Paola;Sanz,LauraM.;Gamo,Francisco-Javier;Lowes,KymN.;McFadden,GeoffreyI.;Wilson,DannyW.;Laleu,Benoît;Brand,Stephen;Jackson,PaulF.;Cowman,AlanF.;Sleebs,BradE.[BioorganicChemistry,2021,vol.115]

784-57-6    344567-18-6   
N-3-4-(4-morpholino)benzotrifluoride-2,4-dihydroxythiobenzamide 

[1]Legocki,Jan;Matysiak,Joanna;Niewiadomy,Andrzej;Kostecka,Malgorzata[JournalofAgriculturalandFoodChemistry,2003,vol.51,#2,p.362-368]

926277-91-0    784-57-6   
4-methyl-N-(2-(4-morpholinyl)-5-(trifluoromethyl)phenyl)-3-((3-(4-pyrimidinyl)-2-pyridinyl)oxy)benzamide 

[1]Hodous,BrianL.;Geuns-Meyer,StephanieD.;Hughes,PaulE.;Albrecht,BrianK.;Bellon,Steve;Bready,James;Caenepeel,Sean;Cee,VictorJ.;Chaffee,StuartC.;Coxon,Angela;Emery,Maurice;Fretland,Jenne;Gallant,Paul;Gu,Yan;Hoffman,Doug;Johnson,RebeccaE.;Kendall,Richard;Kim,JosephL.;Long,AlexanderM.;Morrison,Michael;Olivieri,PhilipR.;Patel,VinodF.;Polverino,Anthony;Rose,Paul;Tempest,Paul;Wang,Ling;Whittington,DouglasA.;Zhao,Huilin[JournalofMedicinalChemistry,2007,vol.50,#4,p.611-626]

926277-89-6    784-57-6   
4-methyl-3-((3-(2-(methylamino)-4-pyrimidinyl)-2-pyridinyl)oxy)-N-(2-(4-morpholinyl)-5-(trifluoromethyl)phenyl)benzamide 

[1]Hodous,BrianL.;Geuns-Meyer,StephanieD.;Hughes,PaulE.;Albrecht,BrianK.;Bellon,Steve;Bready,James;Caenepeel,Sean;Cee,VictorJ.;Chaffee,StuartC.;Coxon,Angela;Emery,Maurice;Fretland,Jenne;Gallant,Paul;Gu,Yan;Hoffman,Doug;Johnson,RebeccaE.;Kendall,Richard;Kim,JosephL.;Long,AlexanderM.;Morrison,Michael;Olivieri,PhilipR.;Patel,VinodF.;Polverino,Anthony;Rose,Paul;Tempest,Paul;Wang,Ling;Whittington,DouglasA.;Zhao,Huilin[JournalofMedicinalChemistry,2007,vol.50,#4,p.611-626]

Literature

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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