Home Other Building Blocks 789-61-7
789-61-7,MFCD00672275
Catalog No.:AA00G35U

789-61-7 | 6-Thio-dG

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1mg
≥95%
in stock  
$46.00   $32.00
- +
5mg
≥95%
in stock  
$133.00   $93.00
- +
10mg
≥95%
in stock  
$175.00   $122.00
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25mg
≥95%
in stock  
$415.00   $290.00
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50mg
97%
in stock  
$693.00   $485.00
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100mg
97%
in stock  
$1,011.00   $708.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G35U
Chemical Name:
6-Thio-dG
CAS Number:
789-61-7
Molecular Formula:
C10H13N5O3S
Molecular Weight:
283.3069
MDL Number:
MFCD00672275
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1nc(N)[nH]c2=S
Properties
Computed Properties
 
Complexity:
420  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
-0.8  

Downstream Synthesis Route

[1]Smee,DonaldF.;Finch,RickA.;Avery,ThomasL.;Robins,RolandK.[JournalofHeterocyclicChemistry,1990,vol.27,#4,p.909-918]

[1]Rappaport,HarryP.[Nucleosides,nucleotidesandnucleicacids,2000,vol.19,#4,p.839-843]

[2]Seela;Chen[NucleosidesandNucleotides,1995,vol.14,#3-5,p.863-866]

[3]Kung,Pei-Pei;Jones,RogerA.[TetrahedronLetters,1991,vol.32,#32,p.3919-3922]

[1]Seela;Chen;Bindig;Kazimierczuk[HelveticaChimicaActa,1994,vol.77,#1,p.194-202]

[2]Kung,Pei-Pei;Jones,RogerA.[TetrahedronLetters,1991,vol.32,#32,p.3919-3922]

[1]Xu,Yao-Zhong;Zheng,Qinguo;Swann,PeterF.[TetrahedronLetters,1991,vol.32,#24,p.2817-2820]

[1]Hanna;Ramasamy;Robins;Revankar[JournalofHeterocyclicChemistry,1988,vol.25,#6,p.1899-1903]

Literature

Title: Oligodeoxynucleotide containing s-functionalized 2'-deoxy-6-thioguanosine: facile tools for base-selective and site-specific internal modification of RNA.

Journal: Current protocols in nucleic acid chemistry 20120301

Title: Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.

Journal: British journal of cancer 20110607

Title: A new odorless procedure for the synthesis of 2'-deoxy-6-thioguanosine and its incorporation into oligodeoxynucleotides.

Journal: Nucleosides, nucleotides & nucleic acids 20090801

Title: Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells.

Journal: British journal of cancer 20060116

Title: Structure and dynamics of thioguanine-modified duplex DNA.

Journal: The Journal of biological chemistry 20030110

Title: Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010901

Title: Mender I, et al. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discov. 2015 Jan;5(1):82-95.

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SDS
Tags:789-61-7 Molecular Formula|789-61-7 MDL|789-61-7 SMILES|789-61-7 6-Thio-dG