Home Amines 78966-69-5
78966-69-5,MFCD00055057
Catalog No.:AA00G2FD

78966-69-5 | DL-2-AMINO-7-PHOSPHONOHEPTANOIC ACID

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
2 weeks  
$700.00   $490.00
- +
10mg
2 weeks  
$890.00   $623.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G2FD
Chemical Name:
DL-2-AMINO-7-PHOSPHONOHEPTANOIC ACID
CAS Number:
78966-69-5
Molecular Formula:
C7H16NO5P
Molecular Weight:
225.1794
MDL Number:
MFCD00055057
SMILES:
NC(C(=O)O)CCCCCP(=O)(O)O
NSC Number:
672105
Properties
Computed Properties
 
Complexity:
226  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-3.6  

Literature

Title: L-NOARG-induced catalepsy can be influenced by glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus.

Journal: Behavioural brain research 20121001

Title: Glutamatergic mechanisms of the dorsal periaqueductal gray matter modulate the expression of conditioned freezing and fear-potentiated startle.

Journal: Neuroscience 20120906

Title: Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.

Journal: Experimental neurology 20120101

Title: The role of the glutathione system in seizures induced by diphenyl diselenide in rat pups.

Journal: Chemico-biological interactions 20110815

Title: Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation.

Journal: Endocrine 20110801

Title: Involvement of NMDA receptor complex in the anxiolytic-like effects of chlordiazepoxide in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20110601

Title: Blockade of NMDA or NO in the dorsal premammillary nucleus attenuates defensive behaviors.

Journal: Physiology & behavior 20110601

Title: 5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110401

Title: Network oscillations in rod-degenerated mouse retinas.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110209

Title: Pathophysiology, treatment, and animal and cellular models of human ischemic stroke.

Journal: Molecular neurodegeneration 20110101

Title: Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy.

Journal: Brain research 20100819

Title: Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats.

Journal: British journal of pharmacology 20100201

Title: Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease.

Journal: Molecular neurodegeneration 20100101

Title: Blockade of NMDA receptors and nitric oxide synthesis in the dorsolateral periaqueductal gray attenuates behavioral and cellular responses of rats exposed to a live predator.

Journal: Journal of neuroscience research 20090815

Title: Towards a reconceptualization of striatal interactions between glutamatergic and dopaminergic neurotransmission and their contribution to the production of movements.

Journal: Current neuropharmacology 20090601

Title: Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward.

Journal: Behavioral neuroscience 20090201

Title: Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems.

Journal: Experimental & translational stroke medicine 20090101

Title: Microinjection of muscimol into the periaqueductal gray suppresses cardiovascular and neuroendocrine response to air jet stress in conscious rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080901

Title: Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the rat.

Journal: Neuroscience 20080515

Title: Post effect of repetitive exposures to pressure nitrogen-induced narcosis on the dopaminergic activity at atmospheric pressure.

Journal: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 20080101

Title: Developmental patterning of glutamatergic synapses onto retinal ganglion cells.

Journal: Neural development 20080101

Title: Involvement of glutamatergic receptors in the nucleus cuneiformis in modulating morphine-induced antinociception in rats.

Journal: European journal of pain (London, England) 20071101

Title: Endogenous D-serine contributes to NMDA-receptor-mediated light-evoked responses in the vertebrate retina.

Journal: Journal of neurophysiology 20070701

Title: Role of the amygdala in ethanol withdrawal seizures.

Journal: Brain research 20070413

Title: Excitatory amino acid receptor-mediated responses in periaqueductal gray neurons are increased during ethanol withdrawal.

Journal: Neuropharmacology 20070301

Title: The blockade of AMPA-kainate and NMDA receptors in the dorsal periaqueductal gray reduces the effects of diazepam withdrawal in rats.

Journal: Pharmacology, biochemistry, and behavior 20070101

Title: Glutamatergic ionotropic blockade within accumbens disrupts working memory and might alter the endocytic machinery in rat accumbens and prefrontal cortex.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070101

Title: Lack of interaction between NMDA and cholecystokinin-2 receptor-mediated neurotransmission in the dorsolateral periaqueductal gray in the regulation of rat defensive behaviors.

Journal: Life sciences 20061102

Title: Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze.

Journal: Behavioural pharmacology 20061101

Title: Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development.

Journal: Experimental neurology 20060901

Title: In vivo electrical stimulation of rabbit retina: effect of stimulus duration and electrical field orientation.

Journal: Experimental eye research 20060801

Title: c-Fos expression increase in NADPH-diaphorase positive neurons after exposure to a live cat.

Journal: Behavioural brain research 20060603

Title: Medial prefrontal cortex NMDA receptors and nitric oxide modulate the parasympathetic component of the baroreflex.

Journal: The European journal of neuroscience 20060101

Title: Origin of electroretinogram amplitude growth during light adaptation in pigmented rats.

Journal: Visual neuroscience 20060101

Title: Non-vagal apnea evoked by intra-common carotid artery injection of N-methyl-D-aspartic acid (NMDA) in anesthetized rats.

Journal: Acta neurobiologiae experimentalis 20060101

Title: Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model.

Journal: World journal of gastroenterology 20051107

Title: Evidence for the perirhinal cortex as a requisite component in the seizure network following seizure repetition in an inherited form of generalized clonic seizures.

Journal: Brain research 20050628

Title: Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.

Journal: European journal of pharmacology 20050523

Title: The effect of competitive antagonist chain length on NMDA receptor subunit selectivity.

Journal: Neuropharmacology 20050301

Title: Carotid sinus nerve section abolishes NMDA evoked respiratory effects in anaesthetised rats.

Journal: Respiratory physiology & neurobiology 20050215

Title: Neurons in the amygdala play an important role in the neuronal network mediating a clonic form of audiogenic seizures both before and after audiogenic kindling.

Journal: Brain research 20050125

Title: Role of nitric oxide in brain regions related to defensive reactions.

Journal: Neuroscience and biobehavioral reviews 20050101

Title: Role of glutamate ionotropic receptors in the dorsomedial hypothalamic nucleus on anxiety and locomotor behavior.

Journal: Pharmacology, biochemistry, and behavior 20041101

Title: Depressor and bradycardic responses to microinjections of endomorphin-2 into the NTS are mediated via ionotropic glutamate receptors.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20041001

Title: The 5-HT receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC.

Journal: Journal of neurochemistry 20041001

Title: NMDA receptors in the medial zona incerta stimulate luteinizing hormone and prolactin release.

Journal: Cellular and molecular neurobiology 20040601

Title: Ganglion cell contributions to the rat full-field electroretinogram.

Journal: The Journal of physiology 20040215

Title: Ionotropic glutamate-receptor antagonists inhibit the aversive effects of nitric oxide donor injected into the dorsolateral periaqueductal gray of rats.

Journal: Psychopharmacology 20040101

Title: Antidepressant-like effects of NMDA-receptor antagonist injected into the dorsal hippocampus of rats.

Journal: Pharmacology, biochemistry, and behavior 20040101

Title: Carotid baroreflex in the rat: role of glutamate receptors in the medial subnucleus of the solitary tract.

Journal: Neuroscience 20040101

Title: [Experimental approaches to perceptual dysfunction in schizophrenia].

Journal: Revista de neurologia 20030901

Title: The role of ionotropic receptors of glutaminic acid in cardiovascular system. A. The influence of ionotropic receptor NMDA agonist - 1R,3R-ACPD and antagonist - DL-AP7 on the systemic pressure in rats.

Journal: Amino acids 20030601

Title: Identification of the requisite brain sites in the neuronal network subserving generalized clonic audiogenic seizures.

Journal: Brain research 20030328

Title: The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor.

Journal: Psychopharmacology 20030301

Title: Neurons in the periaqueductal gray are critically involved in the neuronal network for audiogenic seizures during ethanol withdrawal.

Journal: Neuropharmacology 20030201

Title: Behavioral effects of D-AP7 in rats subjected to experimental hypoxia.

Journal: Polish journal of pharmacology 20030101

Title: N-methyl-D-aspartate receptors contribute to the baseline noise of retinal ganglion cells.

Journal: Visual neuroscience 20030101

Title: Fast-acting excitatory amino acids are involved in the enhancement of the aversiveness of the electrical stimulation of the inferior colliculus by systemic injections of muscimol.

Journal: Life sciences 20021108

Title: Multisubstrate analogue inhibitors of glucosamine-6-phosphate synthase from Candida albicans.

Journal: Bioorganic & medicinal chemistry letters 20020916

Title: Caudal ventrolateral medulla mediates the depressor response elicited by the greater splanchnic nerve afferent stimulation in rats.

Journal: Neuroscience letters 20020607

Title: AP-7 into the nucleus accumbens disrupts acquisition but does not affect consolidation in a passive avoidance task.

Journal: Physiology & behavior 20020601

Title: Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test.

Journal: Physiology & behavior 20020601

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Anxiolytic-like effects of AP7 injected into the dorsolateral or ventrolateral columns of the periaqueductal gray of rats.

Journal: Psychopharmacology 20020201

Title: [Activation of glutamate ionotropic connections of sensorimotor cortex neurons during conditioning].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20020101

Title: [Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid].

Journal: Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka 20020101

Title: The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific.

Journal: Neuroscience letters 20011201

Title: Neurons in the deep layers of superior colliculus are a requisite component of the neuronal network for seizures during ethanol withdrawal.

Journal: Brain research 20011130

Title: Audiogenic seizure susceptibility is induced by termination of continuous infusion of gamma-aminobutyric acid or an N-methyl-D-aspartic acid Antagonist into the inferior colliculus.

Journal: Experimental neurology 20010901

Title: Excitatory amino acid receptor antagonist 2APH may improve local CBF during cerebral ischemia in cats.

Journal: Acta anaesthesiologica Sinica 20010901

Title: Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat.

Journal: Epilepsy research 20010701

Title: Topical bicuculline to the rat spinal cord induces highly localized allodynia that is mediated by spinal prostaglandins.

Journal: Pain 20010601

Title: Design, synthesis, SAR, and biological evaluation of highly potent benzimidazole-spaced phosphono-alpha-amino acid competitive NMDA antagonists of the AP-6 type.

Journal: Journal of medicinal chemistry 20010510

Title: Aldrin-induced stimulation of locomotor activity and brain regional glutamate.

Journal: Methods and findings in experimental and clinical pharmacology 20010501

Title: Intracellular calcium reduces light-induced excitatory post-synaptic responses in salamander retinal ganglion cells.

Journal: The Journal of physiology 20010401

Title: GABAergic and glutamatergic modulation of exploratory behavior in the dorsomedial hypothalamus.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats.

Journal: Neuroscience 20010101

Title: NMDA receptor antagonists change behavioral activity of rats treated with (S)-4CPG.

Journal: Polish journal of pharmacology 20010101

Title: Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.

Journal: Brain research 19950206

Title: Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine.

Journal: Brain research 19920925

Title: A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.

Journal: Brain research 19891127

Title: Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats.

Journal: Experimental neurology 19880701

Title: Enhancement of opioid cataleptic response by cortical frontal deafferentation or intrastriatal injection of NMDA-receptor antagonists.

Journal: Brain research 19880524

Title: Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.

Journal: Journal of neural transmission 19880101

Title: Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.

Journal: European journal of pharmacology 19871215

Title: Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats.

Journal: Neuroscience letters 19870224

Title: Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats.

Journal: Neuroscience letters 19860925

Title: Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate.

Journal: Neuroscience 19860501

Title: 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats.

Journal: Neuroscience letters 19860227

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:78966-69-5 Molecular Formula|78966-69-5 MDL|78966-69-5 SMILES|78966-69-5 DL-2-AMINO-7-PHOSPHONOHEPTANOIC ACID