[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.6661-6664
[2]BioorganicandMedicinalChemistryLetters,2001,vol.11,p.1907-1910
[1]Porter,RoderickA;Chan,WaiN;Coulton,Steven;Johns,Amanda;Hadley,MichaelS;Widdowson,Katherine;Jerman,JeffreyC;Brough,StephenJ;Coldwell,Martyn;Smart,Darren;Jewitt,Frances;Jeffrey,Phillip;Austin,Nigel[BioorganicandMedicinalChemistryLetters,2001,vol.11,#14,p.1907-1910]
[2]McElhinnyJr.,CharlesJ.;Lewin,AnitaH.;Mascarella,S.Wayne;Runyon,Scott;Brieaddy,Lawrence;Carroll,F.Ivy[BioorganicandMedicinalChemistryLetters,2012,vol.22,#21,p.6661-6664]
[1]Porter,RoderickA;Chan,WaiN;Coulton,Steven;Johns,Amanda;Hadley,MichaelS;Widdowson,Katherine;Jerman,JeffreyC;Brough,StephenJ;Coldwell,Martyn;Smart,Darren;Jewitt,Frances;Jeffrey,Phillip;Austin,Nigel[BioorganicandMedicinalChemistryLetters,2001,vol.11,#14,p.1907-1910]
[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.6661-6664
[1]McElhinnyJr.,CharlesJ.;Lewin,AnitaH.;Mascarella,S.Wayne;Runyon,Scott;Brieaddy,Lawrence;Carroll,F.Ivy[BioorganicandMedicinalChemistryLetters,2012,vol.22,#21,p.6661-6664]
Title: Effects of lisdexamfetamine in a rat model of binge-eating.
Journal: Journal of psychopharmacology (Oxford, England) 20151201
Title: Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats.
Journal: Neuropharmacology 20121201
Title: Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.
Journal: Bioorganic & medicinal chemistry letters 20121101
Title: Effects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cells.
Journal: Regulatory peptides 20121010
Title: OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release.
Journal: Molecular pharmacology 20120801
Title: Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20120615
Title: Orexin receptor type-1 antagonist SB-334867 inhibits the development of morphine analgesic tolerance in rats.
Journal: Peptides 20120501
Title: A septal-hypothalamic pathway drives orexin neurons, which is necessary for conditioned cocaine preference.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120328
Title: Orexin-1 receptor mediation of cocaine seeking in male and female rats.
Journal: The Journal of pharmacology and experimental therapeutics 20120301
Title: OX1 orexin/hypocretin receptor activation of phospholipase D.
Journal: British journal of pharmacology 20120201
Title: Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal.
Journal: Biological psychiatry 20120201
Title: Arousal effects of orexin A on acute alcohol intoxication-induced coma in rats.
Journal: Neuropharmacology 20120201
Title: Effects of orexin and glucose microinjected into the hypothalamic paraventricular nucleus on gastric acid secretion in conscious rats.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120201
Title: Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice.
Journal: Brain research 20120111
Title: Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal.
Journal: PloS one 20120101
Title: Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.
Journal: PloS one 20120101
Title: Evidence for the role of hindbrain orexin-1 receptors in the control of meal size.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111201
Title: An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111102
Title: The influence of orexins on the firing rate and pattern of rat intergeniculate leaflet neurons--electrophysiological and immunohistological studies.
Journal: The European journal of neuroscience 20111101
Title: Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111012
Title: Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.
Journal: Behavioural brain research 20110923
Title: Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period.
Journal: Behavioural brain research 20110801
Title: The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.
Journal: Neuroscience letters 20110708
Title: Stimulatory effect of intracerebroventricular administration of orexin A on food intake in the zebrafish, Danio rerio.
Journal: Peptides 20110701
Title: Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking.
Journal: The international journal of neuropsychopharmacology 20110601
Title: The orexin₁ receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats.
Journal: Brain research 20110519
Title: Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20110515
Title: SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats.
Journal: Pharmacology, biochemistry, and behavior 20110501
Title: Intraventricular administration of neuropeptide S has reward-like effects.
Journal: European journal of pharmacology 20110501
Title: Involvement of the orexin/hypocretin system in ethanol conditioned place preference.
Journal: Psychopharmacology 20110401
Title: Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward.
Journal: Behavioural pharmacology 20110401
Title: Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.
Journal: British journal of pharmacology 20110301
Title: A role for orexin in central vestibular motor control.
Journal: Neuron 20110224
Title: Chemical stimulation of the lateral hypothalamus induces conditioned place preference in rats: Involvement of OX1 and CB1 receptors in the ventral tegmental area.
Journal: Behavioural brain research 20110202
Title: Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin₁ receptors.
Journal: British journal of pharmacology 20110201
Title: Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex.
Journal: British journal of pharmacology 20110201
Title: Effects of orexin-A on propofol anesthesia in rats.
Journal: Journal of anesthesia 20110201
Title: Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal.
Journal: Physiology & behavior 20110110
Title: Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system.
Journal: Addiction biology 20110101
Title: Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats.
Journal: Behavioural brain research 20110101
Title: Effect of orexin-A on phagocytic activity of peritoneal macrophage in starved rats.
Journal: Cellular immunology 20110101
Title: Central orexin-A increases gastric motility in rats.
Journal: Peptides 20101101
Title: Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats.
Journal: Neuroscience letters 20101004
Title: Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness.
Journal: Sleep 20101001
Title: The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat.
Journal: Endocrinology 20100901
Title: Opposite roles of dopamine and orexin in quinpirole-induced excessive drinking: a rat model of psychotic polydipsia.
Journal: Psychopharmacology 20100801
Title: The modulation of orexin A on HCN currents of pyramidal neurons in mouse prelimbic cortex.
Journal: Cerebral cortex (New York, N.Y. : 1991) 20100701
Title: Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat.
Journal: The journal of pain : official journal of the American Pain Society 20100601
Title: Endogenous orexin-A modulates gastric motility by peripheral mechanisms in rats.
Journal: Peptides 20100601
Title: Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.
Journal: Biological psychiatry 20100501
Title: The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats.
Journal: Neuroscience 20100428
Title: Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement.
Journal: Biological psychiatry 20100415
Title: Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA.
Journal: Psychopharmacology 20100401
Title: Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization.
Journal: Brain research 20100304
Title: Orexins excite neurons of the rat cerebellar nucleus interpositus via orexin 2 receptors in vitro.
Journal: Cerebellum (London, England) 20100301
Title: Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100210
Title: The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle.
Journal: Respiratory physiology & neurobiology 20100131
Title: Orexins activates protein kinase C-mediated Ca(2+) signaling in isolated rat primary sensory neurons.
Journal: Physiological research 20100101
Title: Orexin/hypocretin is necessary for context-driven cocaine-seeking.
Journal: Neuropharmacology 20100101
Title: The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization.
Journal: Neurochemistry international 20100101
Title: The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system.
Journal: The European journal of neuroscience 20100101
Title: Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents.
Journal: Anesthesiology 20091101
Title: Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats.
Journal: Psychopharmacology 20091001
Title: Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats.
Journal: Pharmacology, biochemistry, and behavior 20091001
Title: Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090909
Title: Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090801
Title: Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B.
Journal: The Journal of endocrinology 20090801
Title: Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.
Journal: The European journal of neuroscience 20090801
Title: Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol--preferring Sprague--Dawley rats.
Journal: Alcohol (Fayetteville, N.Y.) 20090801
Title: Orexin A modulates neuronal activity of the rodent suprachiasmatic nucleus in vitro.
Journal: The European journal of neuroscience 20090701
Title: Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness.
Journal: The Journal of physiology 20090501
Title: Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus.
Journal: Regulatory peptides 20090410
Title: The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain.
Journal: Neuroscience 20090410
Title: Orexin type 1 receptor antagonist SB 334867 inhibits the central histamine-induced resuscitating effect in rats subjected to haemorrhagic shock.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401
Title: The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.
Journal: Anesthesia and analgesia 20090401
Title: Short food deprivation inhibits orexin receptor 1 expression and orexin-A induced intracellular calcium signaling in acutely isolated duodenal enterocytes.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20090301
Title: Role of the ventromedial hypothalamic orexin-1 receptors in regulation of gastric Acid secretion in conscious rats.
Journal: Journal of neuroendocrinology 20090301
Title: Orexin A attenuates unconditioned sexual motivation in male rats.
Journal: Pharmacology, biochemistry, and behavior 20090201
Title: Orexin A decreases ketamine-induced anesthesia time in the rat: the relevance to brain noradrenergic neuronal activity.
Journal: Anesthesia and analgesia 20090201
Title: I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation.
Journal: Neuroscience 20081210
Title: Insular hypocretin transmission regulates nicotine reward.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20081209
Title: Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
Journal: Brain research 20080811
Title: Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell.
Journal: Biological psychiatry 20080801
Title: Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.
Journal: Endocrinology 20080801
Title: Orexin-2 receptors inhibit primary afferent fiber-evoked responses of ventral roots in the neonatal rat isolated spinal cord.
Journal: Brain research 20080707
Title: Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats.
Journal: Psychopharmacology 20080701
Title: Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells.
Journal: Neuroscience letters 20080509
Title: Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats.
Journal: British journal of pharmacology 20080501
Title: Role of orexin receptors in the nucleus accumbens in dopamine-dependent turning behaviour of rats.
Journal: Neuropharmacology 20080301
Title: Role of the orexinergic system in acute haemorrhage in the rat.
Journal: Neuroscience letters 20080220
Title: The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task.
Journal: Behavioural brain research 20080211
Title: Orexin affects dorsal root ganglion neurons: a mechanism for regulating the spinal nociceptive processing.
Journal: Physiological research 20080101
Title: Food-elicited increases in cortical acetylcholine release require orexin transmission.
Journal: Neuroscience 20071109
Title: The orexin-1 antagonist SB-334867 blocks antipsychotic treatment emergent catalepsy: implications for the treatment of extrapyramidal symptoms.
Journal: Schizophrenia bulletin 20071101
Title: Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20071101
Title: Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation.
Journal: American journal of physiology. Endocrinology and metabolism 20071001
Title: Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20070801
Title: Disinhibition of perifornical hypothalamic neurones activates noradrenergic neurones and blocks pontine carbachol-induced REM sleep-like episodes in rats.
Journal: The Journal of physiology 20070715
Title: The orexin-1 receptor antagonist SB-334867 blocks the effects of antipsychotics on the activity of A9 and A10 dopamine neurons: implications for antipsychotic therapy.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401
Title: Role of dorsal vagal motor nucleus orexin-receptor-1 in glycemic responses to acute versus repeated insulin administration.
Journal: Neuropeptides 20070401
Title: The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze.
Journal: Peptides 20070301
Title: Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat.
Journal: The European journal of neuroscience 20061101
Title: The effect of orexins on intestinal motility in vitro in fed and fasted rats.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101
Title: Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task.
Journal: Behavioural brain research 20061002
Title: Orexin A affects ascending contraction depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum.
Journal: Neuropharmacology 20060901
Title: Hypocretin-1 dose-dependently modulates maternal behaviour in mice.
Journal: Journal of neuroendocrinology 20060801
Title: Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20060701
Title: The orexin system regulates alcohol-seeking in rats.
Journal: British journal of pharmacology 20060701
Title: Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Journal: Anesthesiology 20060501
Title: Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.
Journal: Neuron 20060216
Title: Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111
Title: Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20051227
Title: Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity.
Journal: Peptides 20051101
Title: Lack of interaction between orexinergic and alpha2-adrenergic neuronal systems in rat cerebrocortical slices.
Journal: Neuroscience letters 20051014
Title: Orexin A in the nucleus accumbens stimulates feeding and locomotor activity.
Journal: Brain research 20050719
Title: Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats.
Journal: Brain research 20050517
Title: Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S.
Journal: Behavioural brain research 20050507
Title: Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867.
Journal: Behavioural brain research 20050227
Title: Hypocretinergic control of spinal cord motoneurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040609
Title: Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus.
Journal: Neuropharmacology 20040601
Title: Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo.
Journal: Peptides 20040601
Title: Hypothalamus-brain stem circuitry responsible for vagal efferent signaling to the pancreas evoked by hypoglycemia in rat.
Journal: Journal of neurophysiology 20040401
Title: Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats.
Journal: American journal of physiology. Endocrinology and metabolism 20040401
Title: Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats.
Journal: Physiology & behavior 20040301
Title: Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain.
Journal: The Journal of pharmacology and experimental therapeutics 20031201
Title: Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20031001
Title: Hypocretin-1 causes G protein activation and increases ACh release in rat pons.
Journal: The European journal of neuroscience 20031001
Title: Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats.
Journal: Brain research 20030815
Title: Central orexin A has site-specific effects on luteinizing hormone release in female rats.
Journal: Endocrinology 20030701
Title: Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones.
Journal: The Journal of physiology 20030615
Title: Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat.
Journal: Neuroscience letters 20030508
Title: Orexinergic neurons and barbiturate anesthesia.
Journal: Neuroscience 20030101
Title: Involvement of cholinergic neurons in orexin-induced contraction of guinea pig ileum.
Journal: European journal of pharmacology 20020927
Title: Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test.
Journal: British journal of pharmacology 20020901
Title: Orexins and the treatment of obesity.
Journal: European journal of pharmacology 20020412
Title: Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice.
Journal: Regulatory peptides 20020315
Title: SB-334867-A antagonises orexin mediated excitation in the locus coeruleus.
Journal: Neuropharmacology 20020101
Title: 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.
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Title: Orexin-A, an hypothalamic peptide with analgesic properties.
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Title: SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats.
Journal: The European journal of neuroscience 20010401
Title: Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.
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