[1]Margolin;Delinck;Whalon[JournaloftheAmericanChemicalSociety,1990,vol.112,#8,p.2849-2854]
[2]CurrentPatentAssignee:SANOFI-US4970317,1990,A
[1]Margolin;Delinck;Whalon[JournaloftheAmericanChemicalSociety,1990,vol.112,#8,p.2849-2854]
[1]Margolin;Delinck;Whalon[JournaloftheAmericanChemicalSociety,1990,vol.112,#8,p.2849-2854]
[1]Margolin;Delinck;Whalon[JournaloftheAmericanChemicalSociety,1990,vol.112,#8,p.2849-2854]
[1]Delinck,DeborahL.;Margolin,AlexeyL.[TetrahedronLetters,1990,vol.31,#22,p.3093-3096]
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
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Title: Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial.
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Title: The effects of Castanospermine, an oligosaccharide processing inhibitor, on mononuclear/endothelial cell binding and the expression of cell adhesion molecules.
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Title: Studies on α-glucosidase inhibitors development: magic molecules for the treatment of carbohydrate mediated diseases.
Journal: Mini reviews in medicinal chemistry 20120701
Title: Comparison and characterization of α-amylase inducers in Aspergillus nidulans based on nuclear localization of AmyR.
Journal: Applied microbiology and biotechnology 20120601
Title: Propagation of RML prions in mice expressing PrP devoid of GPI anchor leads to formation of a novel, stable prion strain.
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Title: Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi.
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Title: Purification and partial biochemical characterization of a membrane-bound type II-like α-glucosidase from the yeast morphotype of Sporothrix schenckii.
Journal: Antonie van Leeuwenhoek 20120201
Title: Animal models of dengue virus infection.
Journal: Viruses 20120101
Title: Dengue virus entry as target for antiviral therapy.
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Title: Folding, quality control, and secretion of pancreatic ribonuclease in live cells.
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Title: The role of alpha-glucosidase in germinating barley grains.
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Title: Malectin participates in a backup glycoprotein quality control pathway in the mammalian ER.
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Title: Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotope-coded protein labeling and LC-MALDI.
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Title: Calreticulin controls the rate of assembly of CD1d molecules in the endoplasmic reticulum.
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Title: Diastereoselective nitrenium ion-mediated cyclofunctionalization: total synthesis of (+)-castanospermine.
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Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
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Title: Novel method for chase analysis of oligosaccharide metabolic error caused by xenobiotics.
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Title: Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes.
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Title: A membrane-bound trehalase from Chironomus riparius larvae: purification and sensitivity to inhibition.
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Title: Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.
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Title: A new synthetic access to bicyclic polyhydroxylated alkaloid analogues from pyranosides.
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Title: A flexible approach to azasugars: asymmetric total syntheses of (+)-castanospermine, (+)-7-deoxy-6-epi-castanospermine, and (+)-1-epi-castanospermine.
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Title: N-Glycosylation plays a role in protein folding of human UGT1A9.
Journal: Biochemical pharmacology 20100415
Title: N-glycan-dependent quality control of the Na,K-ATPase beta(2) subunit.
Journal: Biochemistry 20100413
Title: Antiviral therapy for hepatitis C virus: beyond the standard of care.
Journal: Viruses 20100401
Title: Glycosidase inhibition: assessing mimicry of the transition state.
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Title: QSAR Studies on andrographolide derivatives as α-glucosidase inhibitors.
Journal: International journal of molecular sciences 20100101
Title: Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model.
Journal: PloS one 20100101
Title: The compartmentalisation of phosphorylated free oligosaccharides in cells from a CDG Ig patient reveals a novel ER-to-cytosol translocation process.
Journal: PloS one 20100101
Title: Antiangiogenic activity of 2-deoxy-D-glucose.
Journal: PloS one 20100101
Title: Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.
Journal: The FEBS journal 20091201
Title: A concise synthesis of castanospermine by the use of a transannular cyclization.
Journal: The Journal of organic chemistry 20091120
Title: Steviamine, a new class of indolizidine alkaloid [(1R,2S,3R,5R,8aR)-3-hydroxy-meth-yl-5-methyl-octa-hydro-indolizine-1,2-diol hydro-bromide].
Journal: Acta crystallographica. Section E, Structure reports online 20091101
Title: Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue.
Journal: Organic & biomolecular chemistry 20091021
Title: Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
Journal: The Journal of biological chemistry 20091009
Title: Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.
Journal: Current opinion in investigational drugs (London, England : 2000) 20090801
Title: (3aR,8aS,9S,9aR)-9-Hydroxy-perhydro-furo[3,2-f]indolizin-6-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090801
Title: Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.
Journal: Organic & biomolecular chemistry 20090707
Title: Loss of specific chaperones involved in membrane glycoprotein biosynthesis during the maturation of human erythroid progenitor cells.
Journal: The Journal of biological chemistry 20090522
Title: Asymmetric synthesis of (+)-castanospermine through enol ether metathesis-hydroboration/oxidation.
Journal: Organic & biomolecular chemistry 20090521
Title: Synthesis of thiohydantoin-castanospermine glycomimetics as glycosidase inhibitors.
Journal: The Journal of organic chemistry 20090501
Title: (7R,8R,8aS)-8-Hydr-oxy-7-phenyl-per-hydro-indolizin-3-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090401
Title: Promotion of IL-4- and IL-5-dependent differentiation of anti-mu-primed B cells by ascorbic acid 2-glucoside.
Journal: Immunology letters 20090221
Title: Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin.
Journal: The Journal of biological chemistry 20090123
Title: Alpha-glucosidase promotes hemozoin formation in a blood-sucking bug: an evolutionary history.
Journal: PloS one 20090101
Title: Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor.
Journal: Retrovirology 20090101
Title: Tetrapisispora phaffii killer toxin is a highly specific beta-glucanase that disrupts the integrity of the yeast cell wall.
Journal: Microbial cell factories 20090101
Title: Alternative splicing and transcriptome profiling of experimental autoimmune encephalomyelitis using genome-wide exon arrays.
Journal: PloS one 20090101
Title: Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora.
Journal: Chemistry & biology 20081020
Title: Broad-spectrum drugs against viral agents.
Journal: International journal of molecular sciences 20080901
Title: The comparative pathology of the glycosidase inhibitors swainsonine, castanospermine, and calystegines A3, B2, and C1 in mice.
Journal: Toxicologic pathology 20080701
Title: Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine.
Journal: FEBS letters 20080625
Title: Synthesis and evaluation of sulfamide-type indolizidines as glycosidase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: Efficient synthesis of (+)-1,8,8a-tri-epi-swainsonine, (+)-1,2-di-epi-lentiginosine, (+)-9a-epi-homocastanospermine and (-)-9-deoxy-9a-epi-homocastanospermine from a D-glucose-derived aziridine carboxylate, and study of their glycosidase inhibitory activities.
Journal: Organic & biomolecular chemistry 20080221
Title: Indolizidine and quinolizidine alkaloids.
Journal: Natural product reports 20080201
Title: Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses.
Journal: Retrovirology 20080101
Title: Carboazidation of chiral allylsilanes: experimental and theoretical investigations.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101
Title: Synthesis of 1-deoxy-1-hydroxymethyl- and 1-deoxy-1-epi-hydroxymethyl castanospermine as new potential immunomodulating agents.
Journal: Journal of medicinal chemistry 20071101
Title: Indolizidine and quinolizidine alkaloids.
Journal: Natural product reports 20070201
Title: Posttranslational N-glycosylation of the hepatitis B virus large envelope protein.
Journal: Virology journal 20070101
Title: Vinylogous Mukaiyama aldol reactions with 4-oxy-2-trimethylsilyloxypyrroles: relevance to castanospermine synthesis.
Journal: Beilstein journal of organic chemistry 20070101
Title: A divergent asymmetric approach to aza-spiropyran derivative and (1S,8aR)-1-hydroxyindolizidine.
Journal: Beilstein journal of organic chemistry 20070101
Title: Asymmetric [2 + 2] cycloaddition: total synthesis of (-)-swainsonine and (+)-6-epicastanospermine.
Journal: Organic letters 20061012
Title: Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3.
Journal: Antiviral research 20061001
Title: Interference with O-glycosylation in RMA lymphoma cells leads to a reduced in vivo growth of the tumor.
Journal: International journal of cancer 20060915
Title: Intramolecular 5-endo-trig aminomercuration of beta-hydroxy-gamma-alkenylamines: efficient route to a pyrrolidine ring and its application for the synthesis of (+)-castanospermine and analogues.
Journal: The Journal of organic chemistry 20060609
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Characterization of endoplasmic reticulum-associated degradation of a protein S mutant identified in a family of quantitative protein S deficiency.
Journal: Thrombosis research 20060101
Title: A novel approach for N-glycosylation studies using detergent extracted microsomes.
Journal: Molecular and cellular biochemistry 20051001
Title: Glucose trimming of N-glycan in endoplasmic reticulum is indispensable for the growth of Raphanus sativus seedling (kaiware radish).
Journal: Bioscience, biotechnology, and biochemistry 20050701
Title: Novel synthesis of castanospermine and 1-epicastanospermine.
Journal: Organic letters 20050623
Title: Combined donor leucocyte administration and immunosuppressive drug treatment for survival of rat heart allografts.
Journal: Transplant immunology 20041101
Title: Indolizidine and quinolizidine alkaloids.
Journal: Natural product reports 20041001
Title: Conversion of the carbohydrate structures of glycoproteins in roots of Raphanus sativus using several glycosidase inhibitors.
Journal: Journal of biochemistry 20041001
Title: Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways.
Journal: The Journal of biological chemistry 20040910
Title: The chemistry of castanospermine. Direct oxidation of the tetraacetate to the corresponding gamma-lactam.
Journal: Carbohydrate research 20040712
Title: Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C.
Journal: Antiviral chemistry & chemotherapy 20040501
Title: Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts.
Journal: Biochemical and biophysical research communications 20040430
Title: Maturation of hepatic lipase. Formation of functional enzyme in the endoplasmic reticulum is the rate-limiting step in its secretion.
Journal: The Journal of biological chemistry 20040213
Title: The significance of N-linked glycosylation in pig endogenous retrovirus infectivity.
Journal: Biochemical and biophysical research communications 20031017
Title: Indolizidine and quinolizidine alkaloids.
Journal: Natural product reports 20031001
Title: Calreticulin promotes folding/dimerization of human lipoprotein lipase expressed in insect cells (sf21).
Journal: The Journal of biological chemistry 20030801
Title: The cargo receptor ERGIC-53 is a target of the unfolded protein response.
Journal: Biochemical and biophysical research communications 20030516
Title: Selection of a high-energy bioactive conformation of a sulfonium-ion glycosidase inhibitor by the enzyme glucoamylase G2.
Journal: Journal of the American Chemical Society 20030514
Title: New synthetic approach to enantiopure bicyclic sulfonium salts: swainsonine analogues.
Journal: The Journal of organic chemistry 20030418
Title: N-linked oligosaccharide processing, but not association with calnexin/calreticulin is highly correlated with endoplasmic reticulum-associated degradation of antithrombin Glu313-deleted mutant.
Journal: Archives of biochemistry and biophysics 20030315
Title: A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation.
Journal: The Journal of biological chemistry 20030314
Title: Enhancement of neurite outgrowth in PC12 cells stimulated with cyclic AMP and NGF by 6-acylated ascorbic acid 2-O-alpha-glucosides (6-Acyl-AA-2G), novel lipophilic ascorbate derivatives.
Journal: Biological & pharmaceutical bulletin 20030301
Title: EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin.
Journal: Science (New York, N.Y.) 20030227
Title: Expression and role of mannose receptor/terminal high-mannose type oligosaccharide on osteoclast precursors during osteoclast formation.
Journal: The Journal of endocrinology 20030201
Title: Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.
Journal: The Journal of general virology 20030201
Title: Role of oligomannosidic N-glycans in the proliferation, adhesion and signalling of C6 glioblastoma cells.
Journal: Biochimie 20030101
Title: Purification and biochemical characterization of a soluble alpha-glucosidase from the parasite Entamoeba histolytica.
Journal: Antonie van Leeuwenhoek 20030101
Title: Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain.
Journal: The Journal of biological chemistry 20021122
Title: Glycosylation processing inhibition by castanospermine prevents experimental autoimmune encephalomyelitis by interference with IL-2 receptor signal transduction.
Journal: Journal of neuroimmunology 20021101
Title: Involvement of [beta]-glucans in the wide-spectrum antimicrobial activity of Williopsis saturnus var. mrakii MUCL 41968 killer toxin.
Journal: Molecular medicine (Cambridge, Mass.) 20021101
Title: Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.
Journal: European journal of biochemistry 20021001
Title: Isomaltose formed by alpha-glucosidases triggers amylase induction in Aspergillus nidulans.
Journal: Current genetics 20021001
Title: The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy.
Journal: Antiviral research 20020901
Title: Bioavailability of a series of novel acylated ascorbic acid derivatives, 6-O-acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic acids, as an ascorbic acid supplement in rats and guinea pigs.
Journal: Bioscience, biotechnology, and biochemistry 20020801
Title: Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells.
Journal: The Biochemical journal 20020701
Title: No sizable inhibition of glucose-induced insulin secretion by acarbose and castanospermine.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020701
Title: Inhibition of bacterial alpha-glucosidases by castanospermine in pure cultures and activated sludge.
Journal: Applied microbiology and biotechnology 20020601
Title: Biosynthesis and processing of Spodoptera frugiperda alpha-mannosidase III.
Journal: Glycobiology 20020601
Title: Calnexin is associated with and induced by overexpressed human complement protein C2.
Journal: The Anatomical record 20020501
Title: Interferon-gamma increases the expression of glycosylated CD95 in B-leukemic cells: an inducible model to study the role of glycosylation in CD95-signalling and trafficking.
Journal: Cytokine 20020421
Title: Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.
Journal: Chemical communications (Cambridge, England) 20020421
Title: N-linked oligosaccharide chains of Sendai virus fusion protein determine the interaction with endoplasmic reticulum molecular chaperones.
Journal: FEBS letters 20020227
Title: Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway.
Journal: Archives of biochemistry and biophysics 20020115
Title: Synthesis of polyhydroxyindolizidines from 5,6-dihydro-2H-pyran-2-one.
Journal: Carbohydrate research 20011207
Title: Differential effect of combined lipase deficiency (cld/cld) on human hepatic lipase and lipoprotein lipase secretion.
Journal: Journal of lipid research 20011101
Title: Role of cell surface glycosylation in mediating repair of human airway epithelial cell monolayers.
Journal: American journal of physiology. Lung cellular and molecular physiology 20011001
Title: Release of polymannose oligosaccharides from vesicular stomatitis virus G protein during endoplasmic reticulum-associated degradation.
Journal: Glycobiology 20011001
Title: The lectin chaperone calnexin utilizes polypeptide-based interactions to associate with many of its substrates in vivo.
Journal: The Journal of biological chemistry 20010706
Title: Synthesis of nitrogen analogues of salacinol and their evaluation as glycosidase inhibitors.
Journal: Journal of the American Chemical Society 20010704
Title: Monoglucosylated oligomannosides are released during the degradation process of newly synthesized glycoproteins.
Journal: The Journal of biological chemistry 20010622
Title: Synthesis of 5-azacastanospermine, a conformationally restricted azafagomine analogue.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010601
Title: Heterologous over-expression of alpha-1,6-fucosyltransferase from Rhizobium sp.: application to the synthesis of the trisaccharide beta-D-GlcNAc(1-->4)-[alpha-L-Fuc-(1-->6)]-D-GLcNAc, study of the acceptor specificity and evaluation of polyhydroxylated indolizidines as inhibitors.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010601
Title: Inhibition of N-linked glycosylation.
Journal: Current protocols in immunology 20010501
Title: Allylated monosaccharides as precursors in triple reductive amination strategies: synthesis of castanospermine and swainsonine.
Journal: The Journal of organic chemistry 20010309
Title: Characterization of the biosynthesis of human immunodeficiency virus type 1 Env from infected T-cells and the effects of glucose trimming of Env on virion infectivity.
Journal: The Journal of biological chemistry 20010223
Title: Rubella virus glycoprotein interaction with the endoplasmic reticulum calreticulin and calnexin.
Journal: Archives of virology 20010101
Title: Castanospermine, an oligosaccharide processing inhibitor, reduces both lymphocyte-endothelial cell binding and LFA-1alpha membrane expression.
Journal: Transplantation proceedings 20010101
Title: Glycosylation and the cystic fibrosis transmembrane conductance regulator.
Journal: Respiratory research 20010101
Title: Strategies for enhancing monoclonal antibody accumulation in plant cell and organ cultures.
Journal: Biotechnology progress 20010101
Title: The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression.
Journal: Archives of virology 20010101
Title: Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoyl castanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells.
Journal: Antimicrobial agents and chemotherapy 19940801
Title: Inhibition of AIDS virus replication by acemannan in vitro.
Journal: Molecular biotherapy 19910901
Title: 6-0-butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs.
Journal: AIDS (London, England) 19910601
Title: Castanospermine vs. its 6-O-butanoyl analog: a comparison of toxicity and antiviral activity in vitro and in vivo.
Journal: Journal of acquired immune deficiency syndromes 19910101
Title: Inhibitory effect of novel 1-deoxynojirimycin derivatives on HIV-1 replication.
Journal: AIDS (London, England) 19901001
Title: Inhibition of glycoprotein processing and HIV replication by castanospermine analogues.
Journal: Annals of the New York Academy of Sciences 19900101
Title: Anti-HIV activity of castanospermine analogues.
Journal: Lancet (London, England) 19890527
Title: In vitro evaluation of mismatched double-stranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome.
Journal: AIDS research and human retroviruses 19890401
Title: Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro by castanospermine and 3'-azido-3'-deoxythymidine.
Journal: Antimicrobial agents and chemotherapy 19890101
Title: Inhibition of HIV replication by amino-sugar derivatives.
Journal: FEBS letters 19880912
Title: Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19871101
Title: Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Journal: Nature 19871101
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