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80409-16-1,MFCD00021856
Catalog No.:AA00G2NP

80409-16-1 | DL-MANDELIC ACID BENZYL ESTER

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G2NP
Chemical Name:
DL-MANDELIC ACID BENZYL ESTER
CAS Number:
80409-16-1
Molecular Formula:
C15H14O3
Molecular Weight:
242.2699
MDL Number:
MFCD00021856
SMILES:
C1=CC=C(C=C1)COC(=O)C(C2=CC=CC=C2)O
NSC Number:
9522
Properties
Computed Properties
 
Complexity:
253  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.7  

Literature

Title: Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics.

Journal: Molecular pharmaceutics 20150105

Title: Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review.

Journal: Annals of internal medicine 20120619

Title: Once-daily trospium chloride 60 mg extended-release provides effective, long-term relief of overactive bladder syndrome symptoms.

Journal: Neurourology and urodynamics 20110901

Title: Once-daily administration of trospium chloride extended release provides 24-hr coverage of nocturnal and diurnal symptoms of overactive bladder: an integrated analysis of two phase III trials.

Journal: Neurourology and urodynamics 20110401

Title: Trospium chloride once-daily extended release is efficacious and tolerated in elderly subjects (aged ≥ 75 years) with overactive bladder syndrome.

Journal: BJU international 20110201

Title: Oxybutynin and trospium are substrates of the human organic cation transporters.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110201

Title: Once-daily trospium chloride 60 mg extended release in subjects with overactive bladder syndrome who use multiple concomitant medications: Post hoc analysis of pooled data from two randomized, placebo-controlled trials.

Journal: Drugs & aging 20110201

Title: Safety and efficacy of once-daily trospium chloride extended-release in male patients with overactive bladder.

Journal: Urology 20110101

Title: New once-daily formulation for trospium in overactive bladder.

Journal: International journal of clinical practice 20101001

Title: New strategies for medical management of overactive bladder in children.

Journal: Current opinion in urology 20100701

Title: Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100415

Title: Effects of combined use of trospium chloride and melatonin on in vitro contractility of rat urinary bladder.

Journal: Urology 20100401

Title: Editorial comment.

Journal: Urology 20100401

Title: Pharmacokinetics of once-daily trospium chloride 60 mg extended release and twice-daily trospium chloride 20 mg in healthy adults.

Journal: Journal of clinical pharmacology 20100201

Title: Extended-release trospium chloride improves quality of life in overactive bladder.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100101

Title: Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week, multicentre, double-blind, parallel-group trial of trospium chloride in patients with urinary urge incontinence.

Journal: BMC urology 20100101

Title: [Sexual dysfunction in women with overactive bladder and their correction with m-cholinolytic spasmex].

Journal: Urologiia (Moscow, Russia : 1999) 20100101

Title: Trospium chloride extended release is effective and well tolerated in women with overactive bladder syndrome.

Journal: International urogynecology journal and pelvic floor dysfunction 20091201

Title: Trospium chloride once-daily extended release is effective and well tolerated for the treatment of overactive bladder syndrome: an integrated analysis of two randomised, phase III trials.

Journal: International journal of clinical practice 20091201

Title: Trospium chloride and oxybutynin hydrochloride in a german study of adults with urinary urge incontinence: results of a 12-week, multicenter, randomized, double-blind, parallel-group, flexible-dose noninferiority trial.

Journal: Clinical therapeutics 20091101

Title: Trospium and cognition in patients with late onset Alzheimer disease.

Journal: The journal of nutrition, health & aging 20091001

Title: The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090701

Title: Trospium chloride treatment of overactive bladder.

Journal: The Annals of pharmacotherapy 20090201

Title: [Spasmex in the treatment of overactive bladder. Russian experience].

Journal: Urologiia (Moscow, Russia : 1999) 20090101

Title: The effects of reformulation: improved therapeutic index.

Journal: Current urology reports 20081101

Title: Effective treatment of neurogenic detrusor dysfunction by combined high-dosed antimuscarinics without increased side-effects.

Journal: European urology 20080501

Title: Overactive bladder disease: the urge for better therapies.

Journal: Journal of managed care pharmacy : JMCP 20080501

Title: Trospium 60 mg once daily (QD) for overactive bladder syndrome: results from a placebo-controlled interventional study.

Journal: Urology 20080301

Title: Role of trospium chloride in brachytherapy-related detrusor overactivity.

Journal: Urology 20080301

Title: [Comparative characteristics of M-cholinolytics in combined treatment of mixed urinary incontinence in women].

Journal: Urologiia (Moscow, Russia : 1999) 20080101

Title: New drugs and dosage forms.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070915

Title: Comparison of the efficacy and tolerability of solifenacin succinate with or without previous use of trospium chloride.

Journal: International urogynecology journal and pelvic floor dysfunction 20070901

Title: Once daily trospium chloride is effective and well tolerated for the treatment of overactive bladder: results from a multicenter phase III trial.

Journal: The Journal of urology 20070901

Title: Treatment of overactive bladder: selective use of anticholinergic agents with low drug-drug interaction potential.

Journal: Geriatrics 20070501

Title: [M-cholinolytic spasmex and its role in preoperative preparation of patients with urine incontinence].

Journal: Urologiia (Moscow, Russia : 1999) 20070101

Title: [Trospium chloride (spasmex) in the treatment of lower urinary tract symptoms in patients with neurogenic hyperactive urinary bladder caused by vertebrogenic lesions].

Journal: Urologiia (Moscow, Russia : 1999) 20070101

Title: Trospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients?

Journal: International journal of clinical pharmacology and therapeutics 20061201

Title: Trospium chloride: Distinct among other anticholinergic agents available for the treatment of overactive bladder.

Journal: The Urologic clinics of North America 20061101

Title: Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20061101

Title: Predictive power of an in vitro system to assess drug interactions of an antimuscarinic medication: a comparison of in vitro and in vivo drug-drug interaction studies of trospium chloride with digoxin.

Journal: Journal of clinical pharmacology 20060701

Title: Using anticholinergics to treat overactive bladder: the issue of treatment tolerability.

Journal: The American journal of medicine 20060301

Title: Neurogenic bladder treatment by doubling the recommended antimuscarinic dosage.

Journal: Neurourology and urodynamics 20060101

Title: [Tuberculosis of the urinary bladder: diagnosis and treatment].

Journal: Urologiia (Moscow, Russia : 1999) 20060101

Title: Trospium chloride: an anticholinergic quaternary ammonium compound for the treatment of overactive bladder.

Journal: Expert opinion on pharmacotherapy 20050701

Title: Overactive bladder.

Journal: Cleveland Clinic journal of medicine 20050701

Title: The overactive bladder-symptom composite score: a composite symptom score of toilet voids, urgency severity and urge urinary incontinence in patients with overactive bladder.

Journal: The Journal of urology 20050501

Title: Trospium chloride for the treatment of overactive bladder with urge incontinence.

Journal: Clinical therapeutics 20050501

Title: Effects on sleep of anticholinergics used for overactive bladder treatment in healthy volunteers aged > or = 50 years.

Journal: BJU international 20050201

Title: Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways.

Journal: Urology 20050201

Title: Clinical pharmacokinetics of trospium chloride.

Journal: Clinical pharmacokinetics 20050101

Title: [Neurological aspect of the hyperactive urinary bladder syndrome].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Trospium chloride in the treatment of idiopathic and neurogenic detrusor overactivity].

Journal: Urologiia (Moscow, Russia : 1999) 20050101

Title: Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine.

Journal: Current urology reports 20041001

Title: Elevating our therapeutic expectations in overactive bladder.

Journal: Journal of the American Academy of Nurse Practitioners 20041001

Title: Trospium chloride improves overactive bladder symptoms: a multicenter phase III trial.

Journal: The Journal of urology 20040601

Title: [The combined treatment of interstitial cystitis in women with spasmex].

Journal: Urologiia (Moscow, Russia : 1999) 20040101

Title: [Combined treatment of voiding disorders in women with m-cholinolytic and alpha 1-adrenoblocker].

Journal: Urologiia (Moscow, Russia : 1999) 20040101

Title: Trospium chloride in the management of overactive bladder.

Journal: Drugs 20040101

Title: Trospium chloride: a quaternary amine with unique pharmacologic properties.

Journal: Current urology reports 20031201

Title: Update on overactive bladder: pharmacologic approaches on the horizon.

Journal: Current urology reports 20031001

Title: Controlled, double-blind, multicentre clinical trial to investigate long-term tolerability and efficacy of trospium chloride in patients with detrusor instability.

Journal: World journal of urology 20030501

Title: [Urinary incontinence--treatment].

Journal: Deutsche medizinische Wochenschrift (1946) 20030404

Title: [Spasmex treatment of patients with hyperactive urinary bladder].

Journal: Urologiia (Moscow, Russia : 1999) 20030101

Title: Trospium chloride--an effective drug in the treatment of overactive bladder and detrusor hyperreflexia.

Journal: World journal of urology 20011101

Title: Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system.

Journal: Journal of clinical pharmacology 20010601

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