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81872-10-8,MFCD00870957
Catalog No.:AA01EOE7

81872-10-8 | Zofenopril

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5mg
>98.00%
3 weeks  
$550.00   $385.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EOE7
Chemical Name:
Zofenopril
CAS Number:
81872-10-8
Molecular Formula:
C22H23NO4S2
Molecular Weight:
429.5523
MDL Number:
MFCD00870957
SMILES:
O=C(N1C[C@H](C[C@H]1C(=O)O)Sc1ccccc1)[C@@H](CSC(=O)c1ccccc1)C
Properties
Computed Properties
 
Complexity:
587  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
4.4  

Literature

Title: [Efficacy of ACE-inhibitors in patients with recent myocardial infarction. Studies with zofenopril].

Journal: Giornale italiano di cardiologia (2006) 20121001

Title: Long-term clinical experience with zofenopril.

Journal: Expert review of cardiovascular therapy 20120801

Title: Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.

Journal: Pharmacological research 20120301

Title: Cardioprotective effects of zofenopril, enalapril and valsartan against ischaemia/reperfusion injury as well as doxorubicin cardiotoxicity.

Journal: Acta cardiologica 20120201

Title: The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20120110

Title: Comparison between zofenopril and ramipril in combination with acetylsalicylic acid in patients with left ventricular systolic dysfunction after acute myocardial infarction: results of a randomized, double-blind, parallel-group, multicenter, European study (SMILE-4).

Journal: Clinical cardiology 20120101

Title: Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients.

Journal: European journal of clinical pharmacology 20110901

Title: Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20110601

Title: Protective effects of zofenopril on testicular torsion and detorsion injury in rats.

Journal: Urology journal 20110101

Title: Aliskiren, a renin inhibitor, downregulates TNF-α-induced tissue factor expression in HUVECS.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20101201

Title: Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20101201

Title: Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits.

Journal: Journal of cardiovascular pharmacology and therapeutics 20101201

Title: HPLC-DAD method for the simultaneous determination of zofenopril and hydrochlorothiazide in oral pharmaceutical formulations.

Journal: Journal of separation science 20100601

Title: Cardiovascular changes in spontaneously hypertensive rats are improved by chronic treatment with zofenopril.

Journal: British journal of pharmacology 20091201

Title: Serum cholesterol levels on admission and survival in patients with acute myocardial infarction treated with zofenopril: a post hoc analysis of the Survival of Myocardial Infarction Long-term Evaluation trial.

Journal: Fundamental & clinical pharmacology 20091001

Title: ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat.

Journal: Vascular pharmacology 20090101

Title: Zofenopril plus hydrochlorothiazide fixed combination in the treatment of hypertension and associated clinical conditions.

Journal: Cardiovascular therapeutics 20090101

Title: Long-term treatment with sulfhydryl angiotensin-converting enzyme inhibition reduces carotid intima-media thickening and improves the nitric oxide/oxidative stress pathways in newly diagnosed patients with mild to moderate primary hypertension.

Journal: American heart journal 20081201

Title: Effects of early treatment with zofenopril in patients with myocardial infarction and metabolic syndrome: the SMILE Study.

Journal: Vascular health and risk management 20080601

Title: ACE-inhibition ameliorates vascular reactivity and delays diabetes outcome in NOD mice.

Journal: Vascular pharmacology 20080101

Title: Comparison of home and office blood pressure in hypertensive patients treated with zofenopril or losartan.

Journal: Blood pressure. Supplement 20071001

Title: An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension.

Journal: Blood pressure. Supplement 20071001

Title: Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients.

Journal: Blood pressure. Supplement 20071001

Title: Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension.

Journal: Blood pressure. Supplement 20071001

Title: [ACE inhibitors after myocardial infarction: close-up on zofenopril].

Journal: Annales de cardiologie et d'angeiologie 20070601

Title: Effect of sulfhydryl and non-sulfhydryl angiotensin-converting enzyme inhibitors on endothelial function in essential hypertensive patients.

Journal: American journal of hypertension 20070401

Title: Antihypertensive efficacy of zofenopril plus hydrochlorothiazide fixed combination for treatment in metabolic syndrome.

Journal: Advances in therapy 20070101

Title: Fixed combination of zofenopril plus hydrochlorothiazide in the management of hypertension: a review of available data.

Journal: Vascular health and risk management 20061201

Title: Effects of angiotensin-converting-enzyme inhibitors in combination with diuretics on blood pressure and renal injury in nitric oxide-deficiency-induced hypertension in rats.

Journal: Clinical science (London, England : 1979) 20060201

Title: The role of zofenopril in myocardial protection during cardioplegia arrest: an isolated rat heart model.

Journal: Journal of cardiac surgery 20060101

Title: An Angiotensin-converting enzyme inhibitor, zofenopril, prevents renal ischemia/reperfusion injury in rats.

Journal: Annals of clinical and laboratory science 20060101

Title: Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril.

Journal: European journal of pharmacology 20051219

Title: Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension.

Journal: American heart journal 20040701

Title: Cardioprotective effect of zofenopril in perfused rat heart subjected to ischemia and reperfusion.

Journal: Journal of cardiovascular pharmacology 20040201

Title: 11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat.

Journal: Bioorganic & medicinal chemistry 20040201

Title: Effects of the early ACE inhibition in diabetic nonthrombolyzed patients with anterior acute myocardial infarction.

Journal: Diabetes care 20030601

Title: Double-blind comparison between zofenopril and lisinopril in patients with acute myocardial infarction: results of the Survival of Myocardial Infarction Long-term Evaluation-2 (SMILE-2) study.

Journal: American heart journal 20030101

Title: An unusual rearrangement of Zofenopril, a new ACE inhibitor drug: mass spectrometric and conformational studies.

Journal: Journal of mass spectrometry : JMS 20021201

Title: Zofenopril inhibits the expression of adhesion molecules on endothelial cells by reducing reactive oxygen species.

Journal: American journal of hypertension 20021001

Title: Pharmacokinetic and pharmacodynamic comparative study of zofenopril and enalapril in healthy volunteers.

Journal: Arzneimittel-Forschung 20020101

Title: Chronic treatment with sulfhydryl angiotensin-converting enzyme inhibitors reduce susceptibility of plasma LDL to in vitro oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice.

Journal: International journal of cardiology 20011201

Title: Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat.

Journal: European journal of pharmacology 20010223

Title: Protease inhibitors: current status and future prospects.

Journal: Journal of medicinal chemistry 20000210

Title: Lin CJ, et al. Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: interaction of ACE inhibitors with high-affinity H+/peptide symporter. Pharm Res. 1999 May;16(5):609-15.

Title: Sarro GD, et al. Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. Pharmacol Res. 2012 Mar;65(3):285-96.

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