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82413-20-5,MFCD00865556
Catalog No.:AA00G27B

82413-20-5 | Droloxifene

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5mg
≥98%
in stock  
$106.00   $74.00
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10mg
≥98%
in stock  
$169.00   $118.00
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25mg
≥98%
in stock  
$238.00   $166.00
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50mg
≥98%
in stock  
$418.00   $292.00
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100mg
≥98%
in stock  
$797.00   $558.00
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250mg
≥98%
in stock  
$1,349.00   $944.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G27B
Chemical Name:
Droloxifene
CAS Number:
82413-20-5
Molecular Formula:
C26H29NO2
Molecular Weight:
387.5140
MDL Number:
MFCD00865556
SMILES:
CCC(=C(c1cccc(c1)O)c1ccc(cc1)OCCN(C)C)c1ccccc1
Properties
Computed Properties
 
Complexity:
501  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
6.8  

Literature

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: [Effect of tetrandrine in combination with droloxifen on the expression of NF-kappaB protein in K562 and K562/A02 cell lines].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20080501

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: [Using protein chips to study mechanism underlying reversion of drug resistance in leukemia cells in tetrandrine alone or in combination with droloxifene].

Journal: Zhongguo shi yan xue ye xue za zhi 20051201

Title: Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity.

Journal: Acta pharmacologica Sinica 20051001

Title: Effects of progesterone and selective oestrogen receptor modulators on chronic allograft nephropathy in rats.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050201

Title: [Effect of tetrandrine combined with Droloxifen on the expression of bcr/abl of K562 at both mRNA and protein levels].

Journal: Zhongguo shi yan xue ye xue za zhi 20050201

Title: [Reversal effect of tetrandrine in combination with droloxifene on cell line K562/A02 and its correlation with inducted apoptosis].

Journal: Zhongguo shi yan xue ye xue za zhi 20040601

Title: [Study on the relationship between [Ca2+]i and the MDR formation in K562/A02 cells].

Journal: Zhongguo shi yan xue ye xue za zhi 20040401

Title: Effects of conjugated oestrogen and droloxifene on the renin-angiotensin system, blood pressure and renal blood flow in postmenopausal women.

Journal: Clinical endocrinology 20040301

Title: [Status of estrogen receptor affects the drug sensitivity of drug-resistant MCF-7/Adr human breast cancer cells to droloxifene and Adriamycin].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20030401

Title: Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.

Journal: Oncology reports 20030101

Title: Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021001

Title: Pharmacokinetics and metabolism of the anti-oestrogen droloxifene in female human subjects.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020801

Title: [Antiestrogen therapy in the treatment of breast neoplasms].

Journal: Minerva ginecologica 20020601

Title: Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice.

Journal: International journal of cancer 20020510

Title: Phase III randomized trial of droloxifene and tamoxifen as first-line endocrine treatment of ER/PgR-positive advanced breast cancer.

Journal: Breast cancer research and treatment 20020501

Title: Toxicity of antiestrogens.

Journal: The breast journal 20020101

Title: Effects of estrogens and selective estrogen receptor modulators on indicators of cardiovascular health in postmenopausal women.

Journal: Medscape women's health 20020101

Title: Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.

Journal: Chemical research in toxicology 20011201

Title: Reversal effects of droloxifene on multidrug resistance in adriamycin-resistant K562 cell line.

Journal: Acta pharmacologica Sinica 20011101

Title: Differential effects of E and droloxifene on C-reactive protein and other markers of inflammation in healthy postmenopausal women.

Journal: The Journal of clinical endocrinology and metabolism 20010901

Title: Apoptosis induced by droloxifene and C-myc, Bax, Bcl-2 protein expression in corpus luteum of pregnant rats.

Journal: Acta pharmacologica Sinica 20010401

Title: Effects of droloxifene on apoptosis and Bax, Bcl-2 protein expression of luteal cells in pseudopregnant rats.

Journal: Acta pharmacologica Sinica 20010201

Title: Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins.

Journal: The Journal of general virology 20010101

Title: Effects of SERMs on important indicators of cardiovascular health: lipoproteins, hemostatic factors, and endothelial function.

Journal: Women's health issues : official publication of the Jacobs Institute of Women's Health 20010101

Title: [Antiestrogens: mechanism of action and clinical applications].

Journal: Salud publica de Mexico 20010101

Title: Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF-7 human breast cancer cells.

Journal: International journal of cancer 19980911

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