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83397-56-2,MFCD00135717
Catalog No.:AA00G2KK

83397-56-2 | PL017

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  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G2KK
Chemical Name:
PL017
CAS Number:
83397-56-2
Molecular Formula:
C29H37N5O5
Molecular Weight:
535.6346
MDL Number:
MFCD00135717
SMILES:
Oc1ccc(cc1)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N([C@H](C(=O)N1CCC[C@@H]1C(=O)N)Cc1ccccc1)C)N
Properties
Computed Properties
 
Complexity:
885  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
1.5  

Literature

Title: Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.

Journal: European journal of pharmacology 20070214

Title: Effects of GABAB-agonist on rat hypothalamic neurons: functional antagonism with mu-receptor agonist.

Journal: Neuroscience research 20060401

Title: Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].

Journal: Journal of medicinal chemistry 20040311

Title: Antisense oligodeoxynucleotides to mu- and delta-opioid receptor mRNA block the enhanced effects of opioids during intestinal inflammation.

Journal: European journal of pharmacology 20010928

Title: Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.

Journal: European journal of pharmacology 19980807

Title: Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

Journal: NIDA research monograph 19980301

Title: Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain.

Journal: The Journal of pharmacology and experimental therapeutics 19970401

Title: Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.

Journal: Pain 19961201

Title: Neuronal basis for the hyperthermic effect of mu-opioid agonists in rats: decrease in temperature sensitivity of warm-sensitive hypothalamic neurons.

Journal: Neuroscience letters 19961101

Title: Interaction between opioid agonists and neurotensin on thermoregulation in the rat. I. Body temperature.

Journal: The Journal of pharmacology and experimental therapeutics 19950701

Title: mu-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19950601

Title: Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells.

Journal: The Journal of pharmacology and experimental therapeutics 19940901

Title: mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19940601

Title: Effect of ambient temperature on the ability of mu-, kappa- and delta-selective opioid agonists to modulate thermoregulatory mechanisms in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 19940201

Title: Behavioral effects of the mu-opioid peptide agonists DAMGO, DALDA, and PL017 on locomotor activities.

Journal: Pharmacology, biochemistry, and behavior 19931001

Title: A topochemical approach to explain morphiceptin bioactivity.

Journal: Journal of medicinal chemistry 19930319

Title: Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 19890501

Title: Antidiarrheal properties of supraspinal mu and delta and peripheral mu, delta and kappa opioid receptors: inhibition of diarrhea without constipation.

Journal: The Journal of pharmacology and experimental therapeutics 19890401

Title: Roles of central and peripheral mu, delta and kappa opioid receptors in the mediation of gastric acid secretory effects in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 19880201

Title: Peptide opioid antagonist separates peripheral and central opioid antitransit effects.

Journal: The Journal of pharmacology and experimental therapeutics 19871101

Title: Mu opioid antagonist properties of a cyclic somatostatin octapeptide in vivo: identification of mu receptor-related functions.

Journal: The Journal of pharmacology and experimental therapeutics 19870701

Title: Characterization of the binding of a morphine (mu) receptor-specific ligand: Tyr-Pro-NMePhe-D-Pro-NH2, [3H]-PL17.

Journal: Molecular pharmacology 19870401

Title: Potent morphiceptin analogs: structure activity relationships and morphine-like activities.

Journal: The Journal of pharmacology and experimental therapeutics 19831101

Title: Inhibition of an opioid-evoked vagal reflex in rats by naloxone, SMS 201-995 and ICI 154, 129.

Journal: Regulatory peptides 19830701

Title: The role of amino-terminal sequence of beta-endorphin and dynorphin in the determination of opiate receptor type selectivity.

Journal: Life sciences 19830101

Title: K J Chang, et al. Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8.

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