Home Thiazoles 84-97-9
84-97-9,MFCD00156243
Catalog No.:AA00G72Z

84-97-9 | 10-(3-(4-Methylpiperazin-1-yl)propyl)-10H-phenothiazine

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10mg
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  • Technical Information
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Technical Information
Catalog Number:
AA00G72Z
Chemical Name:
10-(3-(4-Methylpiperazin-1-yl)propyl)-10H-phenothiazine
CAS Number:
84-97-9
Molecular Formula:
C20H25N3S
Molecular Weight:
339.4976
MDL Number:
MFCD00156243
SMILES:
CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=CC=CC=C42
NSC Number:
638694
Properties
Computed Properties
 
Complexity:
374  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
4.1  

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Journal: Psychiatria Danubina 20110901

Title: The effect of psychotropic drugs on cytochrome P450 2D (CYP2D) in rat brain.

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Title: Effect of neuroleptics on cytochrome P450 2C11 (CYP2C11) in rat liver.

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Title: Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines.

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Title: The activity of cytochrome P450 CYP2B in rat liver during neuroleptic treatment.

Journal: Pharmacological reports : PR 20070101

Title: Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.

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Title: Perazine for schizophrenia.

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Title: Effect of chronic treatment with perazine on lipopolysaccharide-induced interleukin-1 beta levels in the rat brain.

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Title: Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine.

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Title: Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection.

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Title: Increased serum interleukin-1beta and interleukin-6 in elderly, chronic schizophrenic patients on stable antipsychotic medication.

Journal: Neuropsychiatric disease and treatment 20050601

Title: Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101

Title: Acute psychosis with a mediastinal carcinoma metastasis.

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Title: Direct effects of neuroleptics on the activity of CYP2A in the liver of rats.

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Title: Interactions between neuroleptics and CYP2C6 in rat liver--in vitro and ex vivo study.

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Title: Halogenation of drugs enhances membrane binding and permeation.

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Title: The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes.

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Title: The AMUP study for drug surveillance in psychiatry - a summary of inpatient data.

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Title: Blood dyscrasias induced by psychotropic drugs.

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Title: Schizophrenia.

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Title: Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.

Journal: Journal of mass spectrometry : JMS 20030301

Title: Mechanisms of cellular distribution of psychotropic drugs. Significance for drug action and interactions.

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Title: Which neuroleptic would psychiatrists take for themselves or their relatives?

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Title: Antipsychotic efficacy of the antidepressant trimipramine: a randomized, double-blind comparison with the phenothiazine perazine.

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Title: Effects of cytochrome P-450 inducers on the perazine metabolism in a primary culture of human hepatocytes.

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Title: The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Switching to amisulpride due to hepatic complications.

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Title: Perazine for schizophrenia.

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Title: Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4.

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Title: Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping.

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Title: Neuroleptics normalize increased release of interleukin- 1 beta and tumor necrosis factor-alpha from monocytes in schizophrenia.

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Title: Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7,263 treatment courses.

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Title: The effect of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics and metabolism of perazine in the rat.

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Title: Prevalence of obesity in adolescent and young adult patients with and without schizophrenia and in relationship to antipsychotic medication.

Journal: Journal of psychiatric research 20010101

Title: Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver.

Journal: Polish journal of pharmacology 20010101

Title: Examination of iron (III) and hexacyanoferrate (III) ions as reagents for the spectrophotometric determination of promazine and perazine.

Journal: Acta poloniae pharmaceutica 20010101

Title: Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro.

Journal: Psychopharmacology 20000901

Title: An acute psychotic disorder caused by pefloxacin: a case report.

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Title: [Electroconvulsive therapy in treatment of acute life threatening catatonia in toxic epidermal necrolysis (Lyell syndrome)].

Journal: Der Nervenarzt 19920501

Title: Neurologic complications in patients treated with lithium.

Journal: Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa 19880901

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Tags:84-97-9 Molecular Formula|84-97-9 MDL|84-97-9 SMILES|84-97-9 10-(3-(4-Methylpiperazin-1-yl)propyl)-10H-phenothiazine