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847239-17-2,MFCD18086862
Catalog No.:AA008GNB

847239-17-2 | UVI 3003

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$38.00   $27.00
- +
5mg
98%
in stock  
$96.00   $68.00
- +
10mg
98%
in stock  
$144.00   $101.00
- +
25mg
98%
in stock  
$255.00   $178.00
- +
50mg
98%
in stock  
$428.00   $300.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008GNB
Chemical Name:
UVI 3003
CAS Number:
847239-17-2
Molecular Formula:
C28H36O4
Molecular Weight:
436.5830
MDL Number:
MFCD18086862
SMILES:
CCCCCOc1cc2c(cc1c1cc(/C=C/C(=O)O)ccc1O)C(C)(C)CCC2(C)C
Properties
Computed Properties
 
Complexity:
652  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
8  

Literature

Title: The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis.

Journal: Toxicology and applied pharmacology 20170101

Title: Quantitative toxicoproteomic analysis of zebrafish embryos exposed to a retinoid X receptor antagonist UVI3003.

Journal: Journal of applied toxicology : JAT 20150901

Title: A representative retinoid X receptor antagonist UVI3003 induced teratogenesis in zebrafish embryos.

Journal: Journal of applied toxicology : JAT 20150301

Title: Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling.

Journal: Microbes and infection 20140201

Title: FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.

Journal: Circulation research 20100305

Title: Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles.

Journal: European journal of medicinal chemistry 20090601

Title: Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.

Journal: Journal of medicinal chemistry 20090528

Title: Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

Journal: The Journal of biological chemistry 20050114

Title: Zhu J, et al. The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicol Appl Pharmacol. 2017 Jan 1;314:91-97.

Title: Hebert SL, et al. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res. 2017 Dec 1;361(1):101-111.

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