[1]CurrentPatentAssignee:PHARMUKALABORATORIES-US4499094,1985,A
[1]CurrentPatentAssignee:THEROCKEFELLERUNIVERSITY-US2013/244325,2013,A1Locationinpatent:Paragraph0064
Title: Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.
Journal: Archives of toxicology 20170601
Title: Propagation of damage in the rat brain following sarin exposure: Differential progression of early processes.
Journal: Toxicology and applied pharmacology 20161101
Title: Improved assays for xenosensor activation based on reverse transfection.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151001
Title: Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).
Journal: Toxicology letters 20150304
Title: Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.
Journal: The Biochemical journal 20140215
Title: Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction.
Journal: Cellular signalling 20131201
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Journal: European journal of medicinal chemistry 20130501
Title: Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease.
Journal: Neurobiology of aging 20130101
Title: TO901317, a potent LXR agonist, is an inverse agonist of CAR.
Journal: The Journal of toxicological sciences 20130101
Title: A translocator protein ligand PK11195 shows antigrowth activity in human choriocarcinoma cells.
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20121001
Title: Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands.
Journal: Bioorganic & medicinal chemistry 20120915
Title: The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress.
Journal: The Journal of endocrinology 20120801
Title: Effects of minocycline on endogenous neural stem cells after experimental stroke.
Journal: Neuroscience 20120726
Title: The nitric oxide donor sodium nitroprusside requires the 18 kDa Translocator Protein to induce cell death.
Journal: Apoptosis : an international journal on programmed cell death 20120701
Title: The 18 kDa translocator protein influences angiogenesis, as well as aggressiveness, adhesion, migration, and proliferation of glioblastoma cells.
Journal: Pharmacogenetics and genomics 20120701
Title: Non-invasive anatomic and functional imaging of vascular inflammation and unstable plaque.
Journal: European heart journal 20120601
Title: Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.
Journal: Journal of medicinal chemistry 20120510
Title: The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression.
Journal: Current molecular medicine 20120501
Title: Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells.
Journal: Current molecular medicine 20120501
Title: PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells.
Journal: Current molecular medicine 20120501
Title: Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa).
Journal: Current molecular medicine 20120501
Title: Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [¹⁸F]DPA-714.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120425
Title: Solution structures of the prototypical 18 kDa translocator protein ligand, PK 11195, elucidated with 1H/13C NMR spectroscopy and quantum chemistry.
Journal: ACS chemical neuroscience 20120418
Title: Role of neurosteroids in the anticonvulsant activity of midazolam.
Journal: British journal of pharmacology 20120401
Title: Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.
Journal: Experimental neurology 20120301
Title: 18F-FEAnGA for PET of β-glucuronidase activity in neuroinflammation.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120301
Title: Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatum.
Journal: ACS chemical neuroscience 20120215
Title: PK11195, a specific ligand of the peripheral benzodiazepine receptor, may protect pancreatic beta-cells from cytokine-induced cell death.
Journal: Artificial cells, blood substitutes, and immobilization biotechnology 20120201
Title: Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling.
Journal: Biochemical and biophysical research communications 20120113
Title: An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120101
Title: Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101
Title: Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.
Journal: Current radiopharmaceuticals 20120101
Title: The 18 kDa translocator protein (peripheral benzodiazepine receptor) expression in the bone of normal, osteoprotegerin or low calcium diet treated mice.
Journal: PloS one 20120101
Title: Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.
Journal: PloS one 20120101
Title: New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists.
Journal: Molecular pharmaceutics 20111205
Title: In vitro mitochondrial effects of PK 11195, a synthetic translocator protein 18 kDa (TSPO) ligand, in human osteoblast-like cells.
Journal: Journal of bioenergetics and biomembranes 20111201
Title: Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold.
Journal: Journal of medicinal chemistry 20111027
Title: Synthesis and evaluation of novel carbon-11 labeled oxopurine analogues for positron emission tomography imaging of translocator protein (18 kDa) in peripheral organs.
Journal: Journal of medicinal chemistry 20110908
Title: Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.
Journal: European journal of medicinal chemistry 20110901
Title: Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum.
Journal: Blood 20110825
Title: Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.
Journal: Bioorganic & medicinal chemistry letters 20110815
Title: N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors.
Journal: Journal of medicinal chemistry 20110428
Title: Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).
Journal: Toxicology letters 20110425
Title: Multiparametric assessment of acute and subacute ischemic neuronal damage: a small animal positron emission tomography study with rat photochemically induced thrombosis model.
Journal: Synapse (New York, N.Y.) 20110301
Title: Translocator protein (18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state.
Journal: Glia 20110201
Title: Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions.
Journal: Glia 20110201
Title: Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury.
Journal: Neuroscience letters 20110113
Title: Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.
Journal: Journal of medicinal chemistry 20110113
Title: Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats.
Journal: Journal of endocrinological investigation 20110101
Title: Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110101
Title: Mixed-affinity binding in humans with 18-kDa translocator protein ligands.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110101
Title: Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study.
Journal: Journal of neuroinflammation 20110101
Title: Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands.
Journal: Chemico-biological interactions 20101205
Title: 4'-chlorodiazepam--agonist of peripheral benzodiazepine receptors as a protecting factor in IL-1 induced deregulation of collagen biosynthesis in cultured human chondrocytes.
Journal: European journal of pharmacology 20101125
Title: Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).
Journal: Bioorganic & medicinal chemistry letters 20101001
Title: Decreases in binding capacity of the mitochondrial 18 kda translocator protein accompany oxidative stress and pathological signs in rat liver after DMBA exposure.
Journal: Toxicologic pathology 20101001
Title: Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value.
Journal: Inflammatory bowel diseases 20100901
Title: Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20100901
Title: Imaging of vascular inflammation with [11C]-PK11195 and positron emission tomography/computed tomography angiography.
Journal: Journal of the American College of Cardiology 20100817
Title: Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats.
Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20100801
Title: In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomography.
Journal: Synapse (New York, N.Y.) 20100801
Title: 18F-FEAC and 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100801
Title: A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells.
Journal: The Journal of toxicological sciences 20100801
Title: Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells.
Journal: Molecular and cellular biochemistry 20100701
Title: Ca 2+ -dependent autophagy is enhanced by the pharmacological agent PK11195.
Journal: Autophagy 20100701
Title: PK11195 might selectively suppress the quinolinic acid-induced enhancement of anaerobic glycolysis in glial cells.
Journal: Brain research 20100622
Title: Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis.
Journal: Atherosclerosis 20100601
Title: Suppressive effect of diazepam on IFN-gamma production by human T cells.
Journal: International immunopharmacology 20100301
Title: Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker.
Journal: NeuroImage 20100215
Title: Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.
Journal: Journal of neurochemistry 20100201
Title: New iodinated quinoline-2-carboxamides for SPECT imaging of the translocator protein.
Journal: Bioorganic & medicinal chemistry letters 20100201
Title: Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo.
Journal: European journal of pharmacology 20100125
Title: Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).
Journal: Movement disorders : official journal of the Movement Disorder Society 20100115
Title: [11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
Journal: Parkinsonism & related disorders 20100101
Title: PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells.
Journal: International journal of molecular medicine 20100101
Title: PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100101
Title: Translocator protein (18 kDa) is involved in primitive erythropoiesis in zebrafish.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091201
Title: [Radiosynthesis of peripheral benzodiazepine receptor radioligand [N-methyl-(11)C]PK 11195 as an imaging agent for positron emission tomography].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20091201
Title: Multimodal microglia imaging of fiber tracts in acute subcortical stroke.
Journal: Annals of neurology 20091201
Title: Neuroinflammation in the living brain of Parkinson's disease.
Journal: Parkinsonism & related disorders 20091201
Title: [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis.
Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20091101
Title: [Imaging of brain microgliosis by PET].
Journal: Rinsho shinkeigaku = Clinical neurology 20091101
Title: Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial learning deficits.
Journal: Neuroscience 20091020
Title: Imaging of peripheral-type benzodiazepine receptor in tumor: in vitro binding and in vivo biodistribution of N-benzyl-N-[(11)C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide.
Journal: Nuclear medicine and biology 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Translocator protein blockade reduces prostate tumor growth.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091001
Title: Positron emission tomography imaging of neuroinflammation.
Journal: Journal of child neurology 20090901
Title: Distribution, pharmacological characterization and function of the 18 kDa translocator protein in rat small intestine.
Journal: Biology of the cell 20090731
Title: Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.
Journal: Science (New York, N.Y.) 20090724
Title: CoCl(2) induces apoptosis via the 18 kDa translocator protein in U118MG human glioblastoma cells.
Journal: Biochemistry 20090602
Title: Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: a double tracer [11C]PK11195- and [18F]FDG-PET study.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090601
Title: Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.
Journal: Journal of pharmacological sciences 20090501
Title: Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis.
Journal: European journal of nuclear medicine and molecular imaging 20090401
Title: Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography.
Journal: European journal of nuclear medicine and molecular imaging 20090401
Title: Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice.
Journal: Experimental neurology 20090401
Title: Monitoring disease evolution and treatment response in lysosomal disorders by the peripheral benzodiazepine receptor ligand PK11195.
Journal: Neurobiology of disease 20090401
Title: [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain.
Journal: Bioorganic & medicinal chemistry letters 20090315
Title: The effects of 3-methylclonazepam on Schistosoma mansoni musculature are not mediated by benzodiazepine receptors.
Journal: European journal of pharmacology 20090315
Title: Image-derived input functions for PET brain studies.
Journal: European journal of nuclear medicine and molecular imaging 20090301
Title: Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090301
Title: The translocator protein (18 kDa): central nervous system disease and drug design.
Journal: Journal of medicinal chemistry 20090212
Title: Molecular imaging reveals unique degenerative changes in experimental glaucoma.
Journal: Neuroreport 20090128
Title: Microglial activation and amyloid deposition in mild cognitive impairment: a PET study.
Journal: Neurology 20090106
Title: Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques.
Journal: European journal of nuclear medicine and molecular imaging 20090101
Title: Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
Journal: Reproduction (Cambridge, England) 20090101
Title: Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Journal: Archives of neurology 20090101
Title: Bacterial ortholog of mammalian translocator protein (TSPO) with virulence regulating activity.
Journal: PloS one 20090101
Title: Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation.
Journal: European journal of nuclear medicine and molecular imaging 20081201
Title: Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study.
Journal: Neurobiology of disease 20081201
Title: Neuroprotective effect of Ro5-4864 following brain injury.
Journal: Experimental neurology 20081201
Title: Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons.
Journal: Neurochemistry international 20081201
Title: Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195.
Journal: Biochemical pharmacology 20081201
Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Journal: Journal of medicinal chemistry 20081127
Title: Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area.
Journal: Behavioural brain research 20081121
Title: 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies.
Journal: Journal of medicinal chemistry 20081113
Title: Increased peripheral benzodiazepine receptors in arterial plaque of patients with atherosclerosis: an autoradiographic study with [(3)H]PK 11195.
Journal: Atherosclerosis 20081101
Title: Hypothalamic involvement in Huntington's disease: an in vivo PET study.
Journal: Brain : a journal of neurology 20081101
Title: Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography.
Journal: Arthritis and rheumatism 20081101
Title: The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders.
Journal: Journal of neuropathology and experimental neurology 20081001
Title: Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Journal: Journal of medicinal chemistry 20080925
Title: Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
Journal: The journal of pain : official journal of the American Pain Society 20080801
Title: The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.
Journal: Molecular pharmacology 20080801
Title: Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080801
Title: Effect of translocator protein (18 kDa)-ligand binding on neurotransmitter-induced salivary secretion in rat submandibular glands.
Journal: Biology of the cell 20080701
Title: Rapid and efficient radiosynthesis of [123I]I-PK11195, a single photon emission computed tomography tracer for peripheral benzodiazepine receptors.
Journal: Nuclear medicine and biology 20080701
Title: Effects of topiramate on seizure susceptibility in kainate-kindled rats: involvement of peripheral-type benzodiazepine receptors.
Journal: Seizure 20080601
Title: Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080601
Title: Effects of long-term low-dose hormone replacement therapy on the binding capacity of platelet peripheral-type benzodiazepine receptor in postmenopausal women.
Journal: Psychoneuroendocrinology 20080601
Title: Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.
Journal: Bioorganic & medicinal chemistry 20080601
Title: Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 positron emission tomography.
Journal: Pediatric neurology 20080601
Title: In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum.
Journal: Annals of nuclear medicine 20080601
Title: Methamphetamine causes microglial activation in the brains of human abusers.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080528
Title: Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Journal: Psychopharmacology 20080501
Title: VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.
Journal: Journal of neurochemistry 20080401
Title: Quinolinic acid induced neurodegeneration in the striatum: a combined in vivo and in vitro analysis of receptor changes and microglia activation.
Journal: European journal of nuclear medicine and molecular imaging 20080401
Title: Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain.
Journal: Synapse (New York, N.Y.) 20080401
Title: PET image denoising using a synergistic multiresolution analysis of structural (MRI/CT) and functional datasets.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080401
Title: Radiosynthesis and in vivo evaluation of N-[11C]methylated imidazopyridineacetamides as PET tracers for peripheral benzodiazepine receptors.
Journal: Nuclear medicine and biology 20080401
Title: Synthesis and structure-activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem.
Journal: Bioorganic & medicinal chemistry 20080315
Title: Comparative anticancer effects of flavonoids and diazepam in cultured cancer cells.
Journal: Biological & pharmaceutical bulletin 20080201
Title: Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats.
Journal: The European journal of neuroscience 20080201
Title: A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse.
Journal: Neuroscience 20080124
Title: Functional neuroimaging in multiple sclerosis with radiolabelled glia markers: preliminary comparative PET studies with [11C]vinpocetine and [11C]PK11195 in patients.
Journal: Journal of the neurological sciences 20080115
Title: The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080101
Title: Steroidogenesis in BeWo cells: role of protein kinase A and benzodiazepines.
Journal: The international journal of biochemistry & cell biology 20080101
Title: Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine.
Journal: Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101
Title: The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
Journal: Metabolic brain disease 20071201
Title: Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20071201
Title: The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells.
Journal: Haematologica 20071201
Title: In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats.
Journal: Neuroscience letters 20071127
Title: Translocator protein (18 kDa) ligand PK 11195 induces transient mitochondrial Ca2+ release leading to transepithelial Cl- secretion in HT-29 human colon cancer cells.
Journal: Biology of the cell 20071101
Title: In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
Journal: Glia 20071101
Title: Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.
Journal: Neuroscience letters 20071016
Title: Quantifying the A1AR distribution in peritumoural zones around experimental F98 and C6 rat brain tumours.
Journal: Journal of neuro-oncology 20071001
Title: The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
Journal: Journal of neuro-oncology 20071001
Title: A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
Journal: Journal of neurochemistry 20070901
Title: The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.
Journal: Experimental neurology 20070901
Title: PKC activation sets an upper limit to the functional plasticity of GABAergic transmission induced by endogenous neurosteroids.
Journal: The European journal of neuroscience 20070901
Title: Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands.
Journal: Neuropharmacology 20070801
Title: Pharmacological characterization of the receptor mediating the anorexigenic action of the octadecaneuropeptide: evidence for an endozepinergic tone regulating food intake.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070701
Title: Characterization of two classes of benzodiazepine binding sites in Schistosoma mansoni.
Journal: Parasitology 20070701
Title: Microglial activation in presymptomatic Huntington's disease gene carriers.
Journal: Brain : a journal of neurology 20070701
Title: Peripheral-type benzodiazepine receptors in bronchoalveolar lavage cells of patients with interstitial lung disease.
Journal: Nuclear medicine and biology 20070701
Title: Positron emission tomography imaging of neuroinflammation.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070701
Title: Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070601
Title: A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195.
Journal: NeuroImage 20070515
Title: Imaging microglial activation in Huntington's disease.
Journal: Brain research bulletin 20070430
Title: Peripheral benzodiazepine receptor ligand, PK11195 induces mitochondria cytochrome c release and dissipation of mitochondria potential via induction of mitochondria permeability transition.
Journal: European journal of pharmacology 20070410
Title: Peripheral-type benzodiazepine receptor (PBR) aggregation and absence of steroidogenic acute regulatory protein (StAR)/PBR association in the mitochondrial membrane as determined by bioluminescence resonance energy transfer (BRET).
Journal: The Journal of steroid biochemistry and molecular biology 20070401
Title: 11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070401
Title: Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation.
Journal: Molecular cancer research : MCR 20070401
Title: Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor.
Journal: Bioorganic & medicinal chemistry letters 20070315
Title: N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
Journal: Journal of medicinal chemistry 20070222
Title: Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome.
Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20070201
Title: New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.
Journal: Journal of medicinal chemistry 20070125
Title: PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.
Journal: Neuroscience letters 20070116
Title: Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response.
Journal: Current pharmaceutical design 20070101
Title: Effects of peripheral-type benzodiazepine receptor ligands on Ehrlich tumor cell proliferation.
Journal: European journal of pharmacology 20061121
Title: Blood flow dependence of the intratumoral distribution of peripheral benzodiazepine receptor binding in intact mouse fibrosarcoma.
Journal: Nuclear medicine and biology 20061101
Title: Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.
Journal: Journal of medicinal chemistry 20060921
Title: Peripheral benzodiazepine receptors on platelets of fibromyalgic patients.
Journal: Clinical biochemistry 20060901
Title: Nuclear imaging of inflammation in neurologic and psychiatric disorders.
Journal: Current clinical pharmacology 20060901
Title: Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore.
Journal: Cancer letters 20060818
Title: Effects of D-galactose on the expression of hippocampal peripheral-type benzodiazepine receptor and spatial memory performances in rats.
Journal: Psychoneuroendocrinology 20060801
Title: Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain.
Journal: The European journal of neuroscience 20060801
Title: The apparent positive cooperativity of in vivo [3H]PK-11195 binding in mouse fibrosarcoma.
Journal: Nuclear medicine and biology 20060801
Title: Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment.
Journal: Journal of neurovirology 20060801
Title: Peripheral benzodiazepine receptors in the brain of cirrhosis patients with manifest hepatic encephalopathy.
Journal: European journal of nuclear medicine and molecular imaging 20060701
Title: Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.
Journal: Stroke 20060701
Title: Synthesis, labeling, and biological evaluation of halogenated 2-quinolinecarboxamides as potential radioligands for the visualization of peripheral benzodiazepine receptors.
Journal: Bioorganic & medicinal chemistry 20060615
Title: Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites.
Journal: Bioorganic & medicinal chemistry 20060601
Title: Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060601
Title: 5-aryl-imidazo[2,1-c][1,4]benzodiazepine derivatives as tricyclic constrained analogues of diazepam and Ro5-4864. Synthesis and binding properties at peripheral and central benzodiazepine receptors.
Journal: Die Pharmazie 20060601
Title: Mitochondrial ligand inhibits store-operated calcium influx and COX-2 production in human microglia.
Journal: Journal of neuroscience research 20060515
Title: [2-11C]isopropyl-, [1-11C]ethyl-, and [11C]methyl-labeled phenoxyphenyl acetamide derivatives as positron emission tomography ligands for the peripheral benzodiazepine receptor: radiosynthesis, uptake, and in vivo binding in brain.
Journal: Journal of medicinal chemistry 20060504
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Interaction of novel condensed triazine derivatives with central and peripheral type benzodiazepine receptors: synthesis, in vitro pharmacology and modelling.
Journal: European journal of medicinal chemistry 20060401
Title: The effects of prostaglandin F2alpha treatment on peripheral-type benzodiazepine receptors in the ovary and uterus during pseudopregnancy of rats.
Journal: Biochemical pharmacology 20060214
Title: In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease.
Journal: Neurobiology of disease 20060201
Title: [Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands].
Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20060201
Title: In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.
Journal: Movement disorders : official journal of the Movement Disorder Society 20060101
Title: Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells.
Journal: Molecular pharmacology 20060101
Title: COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
Journal: BMC neurology 20060101
Title: A peripheral benzodiazepine receptor targeted agent for in vitro imaging and screening.
Journal: Bioconjugate chemistry 20060101
Title: Antimitotic activity of high affinity ligands for peripheral benzodiazepine receptor (PBR) in some normal and neoplastic cell lines.
Journal: Advances in medical sciences 20060101
Title: The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.
Journal: Pharmacology, biochemistry, and behavior 20051201
Title: PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor.
Journal: Oncogene 20051117
Title: PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism.
Journal: Blood 20051115
Title: Decreased density of peripheral benzodiazepine receptors in psychiatric patients after a suicide attempt.
Journal: Life sciences 20051112
Title: Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
Journal: Neurobiology of disease 20051101
Title: Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20051101
Title: Role of the peripheral benzodiazepine receptor in sensory neuron regeneration.
Journal: Molecular and cellular neurosciences 20051001
Title: A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells.
Journal: Cancer research 20050915
Title: High-affinity peripheral benzodiazepine receptor ligand, PK11195, regulates protein phosphorylation in rat brain mitochondria under control of Ca(2+).
Journal: Journal of neurochemistry 20050801
Title: Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS.
Journal: Journal of neurovirology 20050801
Title: Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells.
Journal: Biochemical and biophysical research communications 20050708
Title: Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050701
Title: Methyl pyropheophorbide-a analogues: potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy.
Journal: Journal of medicinal chemistry 20050602
Title: Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity.
Journal: Bioorganic & medicinal chemistry 20050516
Title: Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding.
Journal: PLoS biology 20050501
Title: Effect of PK11195, a peripheral benzodiazepine receptor agonist, on insulinoma cell death and insulin secretion.
Journal: Apoptosis : an international journal on programmed cell death 20050501
Title: Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation.
Journal: Life sciences 20050415
Title: Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity.
Journal: Journal of neuroscience research 20050401
Title: Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and alpha-keto acid profiles or immune functions.
Journal: Amino acids 20050201
Title: 1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.
Journal: Bioorganic & medicinal chemistry letters 20050201
Title: Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands.
Journal: Journal of medicinal chemistry 20050113
Title: Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis.
Journal: Apoptosis : an international journal on programmed cell death 20050101
Title: Minocycline treatment attenuates microglia activation and non-angiotensin II [125I] CGP42112 binding in brainstem following nodose ganglionectomy.
Journal: Neuroscience 20050101
Title: In vivo detection of microglial activation in frontotemporal dementia.
Journal: Annals of neurology 20041201
Title: Response characteristics of the mitochondrial DNA genome in developmental health and disease.
Journal: Birth defects research. Part C, Embryo today : reviews 20041201
Title: Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline.
Journal: European journal of pharmacology 20041128
Title: Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1.
Journal: Journal of hepatology 20041101
Title: Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Journal: Blood 20041015
Title: GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A.
Journal: Biochemical pharmacology 20041001
Title: In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration.
Journal: Movement disorders : official journal of the Movement Disorder Society 20041001
Title: Peripheral type benzodiazepine receptor in human parathyroid glands: up-regulation in adenoma.
Journal: Journal of endocrinological investigation 20041001
Title: Mitochondria in activated microglia in vitro.
Journal: Journal of neurocytology 20040901
Title: Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons.
Journal: The European journal of neuroscience 20040801
Title: The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets.
Journal: European journal of endocrinology 20040801
Title: Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells.
Journal: Biochemical pharmacology 20040701
Title: Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration.
Journal: Movement disorders : official journal of the Movement Disorder Society 20040701
Title: Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons.
Journal: European journal of pharmacology 20040628
Title: Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20040601
Title: The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin.
Journal: Blood 20040601
Title: Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization.
Journal: Brain : a journal of neurology 20040601
Title: 3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion.
Journal: Journal of neurochemistry 20040601
Title: Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways.
Journal: Biochemical pharmacology 20040515
Title: Evaluation of three quinoline-carboxamide derivatives as potential radioligands for the in vivo pet imaging of neurodegeneration.
Journal: Neurochemistry international 20040501
Title: Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
Journal: Journal of medicinal chemistry 20040422
Title: Antinociceptive effects of peripheral benzodiazepine receptors.
Journal: Pharmacology 20040401
Title: Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid.
Journal: Journal of neurochemistry 20040401
Title: Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.
Journal: Neurobiology of disease 20040401
Title: Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.
Journal: Mediators of inflammation 20040401
Title: N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.
Journal: Journal of medicinal chemistry 20040325
Title: In vitro effects of lead ions on peripheral benzodiazepine receptors and adenylyl cyclase activity in the mantle of Mytilus galloprovincialis.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040201
Title: Involvement of steroids in anti-inflammatory effects of peripheral benzodiazepine receptor ligands.
Journal: Life sciences 20040130
Title: Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA(A) miniature IPSCs in lamina II of the spinal cord.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040128
Title: Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells.
Journal: Journal of cellular physiology 20040101
Title: [3H]PK11195 binding sites in human neutrophils: effect of fMLP stimulation and modulation in rheumatic diseases.
Journal: Clinical biochemistry 20040101
Title: Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro.
Journal: Neurobiology of disease 20031201
Title: Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species.
Journal: Cancer research 20031201
Title: Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study.
Journal: NeuroImage 20031201
Title: Protoporphyrin IX binding and transport by recombinant mouse PBR.
Journal: Biochemical and biophysical research communications 20031128
Title: Effects of acute and long-term diazepam administrations on neutrophil activity: a flow cytometric study.
Journal: European journal of pharmacology 20031008
Title: Structure activity studies of a novel cytotoxic benzodiazepine.
Journal: Bioorganic & medicinal chemistry letters 20031006
Title: Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Journal: Brain pathology (Zurich, Switzerland) 20031001
Title: Ligands of the peripheral benzodiazepine receptor have therapeutic effects in pneumopathies in vivo.
Journal: Immunology letters 20030908
Title: Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands.
Journal: Journal of medicinal chemistry 20030814
Title: Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030701
Title: Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters.
Journal: Journal of neuroendocrinology 20030701
Title: Antidepressant-like effect of Ro5-4864, a peripheral-type benzodiazepine receptor ligand, in forced swimming test.
Journal: European journal of pharmacology 20030613
Title: Cell-type-specific opening of the retinal ganglion cell mitochondrial permeability transition pore.
Journal: Investigative ophthalmology & visual science 20030601
Title: PET visualization of microglia in multiple sclerosis patients using [11C]PK11195.
Journal: European journal of neurology 20030501
Title: Comparison of two PBR ligands with classical antiinflammatory drugs in LPS-induced arthritis in rats.
Journal: Life sciences 20030425
Title: Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Journal: Experimental neurology 20030401
Title: Benzodiazepine-induced protein tyrosine nitration in rat astrocytes.
Journal: Hepatology (Baltimore, Md.) 20030201
Title: Peripheral benzodiazepine receptors: on mice and human brain imaging.
Journal: Journal of neurochemistry 20030201
Title: Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis.
Journal: Journal of neurovirology 20030201
Title: The peripheral benzodiazepine receptor ligand PK11195 binds with high affinity to the acute phase reactant alpha1-acid glycoprotein: implications for the use of the ligand as a CNS inflammatory marker.
Journal: Nuclear medicine and biology 20030201
Title: Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 3. Intervention with PK11195.
Journal: Birth defects research. Part A, Clinical and molecular teratology 20030201
Title: [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).
Journal: Bioorganic & medicinal chemistry letters 20030120
Title: Involvement of the peripheral benzodiazepine receptor in the development of cutaneous pathology in Mrl/Lpr mice.
Journal: Immunology letters 20030102
Title: Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmental area.
Journal: Neuroendocrinology 20030101
Title: Assessment of neuroinflammation and microglial activation in Alzheimer's disease with radiolabelled PK11195 and single photon emission computed tomography. A pilot study.
Journal: European neurology 20030101
Title: Mitochondrial benzodiazepine receptors regulate oxygen homeostasis in the early mouse embryo.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20030101
Title: Peripheral benzodiazepine receptor ligand-melphalan conjugates for potential selective drug delivery to brain tumors.
Journal: Bioconjugate chemistry 20030101
Title: Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells.
Journal: International journal of cancer 20021201
Title: Inhibitory effect of diazepam on muscarinic receptor-stimulated inositol 1,4,5-trisphosphate production in rat parotid acinar cells.
Journal: British journal of pharmacology 20021201
Title: Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells.
Journal: Journal of neurochemistry 20021201
Title: Visualising microglial activation in vivo.
Journal: Glia 20021101
Title: Identification of a peptide antagonist to the peripheral-type benzodiazepine receptor that inhibits hormone-stimulated leydig cell steroid formation.
Journal: The Journal of pharmacology and experimental therapeutics 20021101
Title: Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195.
Journal: Journal of neurochemistry 20021101
Title: Regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of the cholesterol transfer proteins StAR and PBR.
Journal: Endocrine research 20021101
Title: Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells.
Journal: Gut 20021001
Title: The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195.
Journal: Molecular cancer therapeutics 20021001
Title: Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice.
Journal: European journal of pharmacology 20020927
Title: Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
Journal: Journal of medicinal chemistry 20020912
Title: Apoptosis in activated rat pancreatic stellate cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20020901
Title: Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain.
Journal: Journal of neurochemistry 20020801
Title: Modulation of tamoxifen-induced apoptosis by peripheral benzodiazepine receptor ligands in breast cancer cells.
Journal: Biochemical pharmacology 20020701
Title: Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria.
Journal: Journal of neuroscience research 20020701
Title: The role of the peripheral benzodiazepine receptor in photodynamic activity of certain pyropheophorbide ether photosensitizers: albumin site II as a surrogate marker for activity.
Journal: Photochemistry and photobiology 20020701
Title: The peripheral benzodiazepine receptor in photodynamic therapy with the phthalocyanine photosensitizer Pc 4.
Journal: Photochemistry and photobiology 20020601
Title: Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats.
Journal: Pharmacology, biochemistry, and behavior 20020601
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Effect of diazepam and clonazepam on the function of isolated rat platelet and neutrophil.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20020401
Title: Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo.
Journal: Cancer research 20020301
Title: Increased expression of 'peripheral-type' benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis.
Journal: Metabolic brain disease 20020301
Title: Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
Journal: The European journal of neuroscience 20020301
Title: PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.
Journal: Journal of neurochemistry 20020301
Title: Sleep deprivation does not affect indices of necrosis or apoptosis in rat brain.
Journal: The International journal of neuroscience 20020201
Title: PK11195, a peripheral benzodiazepine receptor ligand, chemosensitizes acute myeloid leukemia cells to relevant therapeutic agents by more than one mechanism.
Journal: Leukemia research 20020101
Title: PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro.
Journal: Neoplasma 20020101
Title: Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes.
Journal: European journal of pharmacology 20011207
Title: Confluence of antianalgesic action of diverse agents through brain interleukin(1beta) in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20011101
Title: Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.
Journal: British journal of cancer 20011101
Title: Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings.
Journal: European journal of pharmacology 20011005
Title: 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
Journal: Bioorganic & medicinal chemistry 20011001
Title: Hormonal regulation of peripheral benzodiazepine receptor binding properties is mediated by subunit interaction.
Journal: Biochemistry 20010828
Title: In-vivo measurement of activated microglia in dementia.
Journal: Lancet (London, England) 20010811
Title: Diazepam increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism.
Journal: British journal of pharmacology 20010801
Title: Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model.
Journal: Cancer chemotherapy and pharmacology 20010801
Title: Pro-apoptotic interactions between XK469 and the peripheral benzodiazepine receptor.
Journal: Cancer letters 20010726
Title: Diazepam stimulates migration and phagocytosis of human neutrophils: possible contribution of peripheral-type benzodiazepine receptors and intracellular calcium.
Journal: Pharmacology 20010701
Title: Reversal of reserpine-induced vacuous chewing movements in rats by melatonin: involvement of peripheral benzodiazepine receptors.
Journal: Brain research 20010615
Title: Structural and functional study of reconstituted peripheral benzodiazepine receptor.
Journal: Biochemical and biophysical research communications 20010608
Title: Up-regulation of the peripheral-type benzodiazepine receptor expression and [(3)H]PK11195 binding in gerbil hippocampus after transient forebrain ischemia.
Journal: Journal of neuroscience research 20010601
Title: Normalization of markers for dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts.
Journal: Acta neurologica Scandinavica 20010501
Title: Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species.
Journal: British journal of cancer 20010501
Title: Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone.
Journal: Immunopharmacology and immunotoxicology 20010501
Title: Melatonin enhances Th2 cell mediated immune responses: lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists.
Journal: Molecular and cellular biochemistry 20010501
Title: Peripheral type benzodiazepine binding sites as a tool for the detection and quantification of CNS injury.
Journal: Current protocols in neuroscience 20010501
Title: Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling.
Journal: Journal of medicinal chemistry 20010412
Title: Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells.
Journal: Gastroenterology 20010401
Title: Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue.
Journal: Biochemical pharmacology 20010315
Title: Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.
Journal: British journal of pharmacology 20010201
Title: Negative inotropic effect of diazepam in isolated guinea pig heart.
Journal: The Journal of veterinary medical science 20010201
Title: Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.
Journal: Acta neuropathologica 20010201
Title: The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Journal: Pharmacology, biochemistry, and behavior 20000801
Title: Brain lesions and delayed water maze learning deficits after intracerebroventricular spermine.
Journal: Brain research 19980727
Title: Intrathecally administered flumazenil and PK 11195 precipitate abstinence syndrome in freely moving diazepam dependent rats.
Journal: Drug and alcohol dependence 19961211
Title: PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent.
Journal: Life sciences 19950101
Title: Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.
Journal: Neuroscience 19940901
Title: Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113(4):e170345.
