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856867-55-5,MFCD28098176
Catalog No.:AA00G3OU

856867-55-5 | Tedizolid Phosphate

Pack Size
Purity
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Price(USD)
Quantity
  
10mg
98%
in stock  
$7.00   $5.00
- +
50mg
98%
in stock  
$11.00   $8.00
- +
100mg
98%
in stock  
$15.00   $11.00
- +
250mg
98%
in stock  
$25.00   $18.00
- +
1g
98%
in stock  
$62.00   $43.00
- +
5g
98%
in stock  
$212.00   $149.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G3OU
Chemical Name:
Tedizolid Phosphate
CAS Number:
856867-55-5
Molecular Formula:
C17H16FN6O6P
Molecular Weight:
450.3177
MDL Number:
MFCD28098176
SMILES:
O=C1O[C@H](CN1c1ccc(c(c1)F)c1ccc(nc1)c1nnn(n1)C)COP(=O)(O)O
Properties
Computed Properties
 
Complexity:
702  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
0.3  

Downstream Synthesis Route
856866-72-3   
(5R)-3-{3-fluoro-4-6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-ylphenyl}-2-oxooxazolidin-5-ylmethyldihydrogenphosphate 

[1]Patent:CN107827927,2018,A.Locationinpatent:Paragraph0039;0040

[2]Patent:WO2010/42887,2010,A2.Locationinpatent:Page/Pagecolumn20-21

[3]Patent:CN107722056,2018,A.Locationinpatent:Paragraph0069;0070

[4]Patent:CN105418681,2016,A.Locationinpatent:Paragraph0050;0051

[5]Patent:CN111116652,2020,A.Locationinpatent:Paragraph0020

[6]EuropeanJournalofMedicinalChemistry,2011,vol.46,p.1027-1039

[7]Patent:CN110804038,2020,A.Locationinpatent:Paragraph0076-0077;0079-0080

[8]Patent:WO2015/54246,2015,A1.Locationinpatent:Paragraph0043;0044

[9]Patent:WO2016/88103,2016,A1.Locationinpatent:Page/Pagecolumn19

[10]Patent:WO2016/88103,2016,A1

[11]Patent:CN106317114,2017,A.Locationinpatent:Paragraph0028

Literature

Title: Tedizolid Phosphate: a Next-Generation Oxazolidinone.

Journal: Infectious diseases and therapy 20150301

Title: Tedizolid phosphate for the treatment of acute bacterial skin and skin structure infections.

Journal: Drugs of today (Barcelona, Spain : 1998) 20141101

Title: Single- and multiple-dose pharmacokinetics and absolute bioavailability of tedizolid.

Journal: Pharmacotherapy 20140901

Title: Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20140801

Title: Recent development of potent analogues of oxazolidinone antibacterial agents.

Journal: Bioorganic & medicinal chemistry 20130201

Title: Activity of novel oxazolidinones against Nocardia brasiliensis growing within THP-1 macrophages.

Journal: The Journal of antimicrobial chemotherapy 20091101

Title: Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis.

Journal: Molecules (Basel, Switzerland) 20080111

Title: Pharmacokinetics of DA-7218, a new oxazolidinone, and its active metabolite, DA-7157, after intravenous and oral administration of DA-7218 and DA-7157 to rats.

Journal: The Journal of pharmacy and pharmacology 20070701

Title: In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis.

Journal: Antimicrobial agents and chemotherapy 20060901

Title: Choi S, et al. Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-resistant and Penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012 Jun 19.

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Tags:856867-55-5 Molecular Formula|856867-55-5 MDL|856867-55-5 SMILES|856867-55-5 Tedizolid Phosphate