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86933-74-6,MFCD00167560
Catalog No.:AA004I25

86933-74-6 | Neurokinin A

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5mg
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$906.00   $634.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004I25
Chemical Name:
Neurokinin A
CAS Number:
86933-74-6
Molecular Formula:
C28H46N6O5S
Molecular Weight:
578.7670
MDL Number:
MFCD00167560
SMILES:
CSCCC(C(=O)N)NC(=O)C(NC(=O)CNC(=O)C(C(C)C)NC(=O)C(Cc1ccccc1)NC)CC(C)C
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
2030  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
79  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
16  
Rotatable Bond Count:
37  
XLogP3:
-4.8  

Literature

Title: The tachykinin peptide neurokinin B binds copper(I) and silver(I) and undergoes quasi-reversible electrochemistry: towards a new function for the peptide in the brain.

Journal: Neurochemistry international 20140501

Title: In vitro pharmacological evaluation of the radiolabeled C-terminal substance P analogue Lys-Phe-Phe-Gly-Leu-Met-NH2: Does a specific binding site exist?

Journal: Folia neuropathologica 20140101

Title: Copper(II) complexes of neurokinin A with point mutation (S5A) and products of copper-catalyzed oxidation; role of serine residue in peptides containing neurokinin A sequence.

Journal: Journal of inorganic biochemistry 20130401

Title: Acid-base properties of the (1-4,18-36) fragments of neuropeptide K and their mono- and polynuclear copper(II) complexes products of metal-catalyzed oxidation.

Journal: Inorganic chemistry 20130107

Title: Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B.

Journal: Hippocampus 20120501

Title: Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120401

Title: Tachykinins stimulate a subset of mouse taste cells.

Journal: PloS one 20120101

Title: Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells.

Journal: Cardiovascular research 20111201

Title: Substance P inhibits pancreatic ductal bicarbonate secretion via neurokinin receptors 2 and 3 in the guinea pig exocrine pancreas.

Journal: Pancreas 20110701

Title: Novel expression of a functional glycine receptor chloride channel that attenuates contraction in airway smooth muscle.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501

Title: Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.

Journal: British journal of pharmacology 20110301

Title: Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.

Journal: Journal of investigational allergology & clinical immunology 20110101

Title: Tachykinin receptors antagonism for asthma: a systematic review.

Journal: BMC pulmonary medicine 20110101

Title: Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.

Journal: Journal of pharmacological sciences 20110101

Title: The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism.

Journal: Journal of neuroinflammation 20110101

Title: Secretoneurin and the tachykinins substance P and neurokinin-A/B in NMDA-induced excitotoxicity in the rat retina.

Journal: Regulatory peptides 20101130

Title: Modulation of the CRH system by substance P/NKA in an animal model of depression.

Journal: Behavioural brain research 20101112

Title: Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20101001

Title: Coordination abilities of neurokinin A and its derivative and products of metal-catalyzed oxidation.

Journal: Journal of inorganic biochemistry 20100801

Title: Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene.

Journal: British journal of pharmacology 20100701

Title: Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201

Title: Central administration of substance P inhibits feeding behavior in chicks.

Journal: Hormones and behavior 20100201

Title: Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity.

Journal: Peptides 20100101

Title: Acute morphine effects on respiratory activity in mice with target deletion of the tachykinin 1 gene (Tac1-/-).

Journal: Advances in experimental medicine and biology 20100101

Title: Effect of fluticasone on neuropeptides in nasal lavage in persistent allergic rhinitis.

Journal: Journal of investigational allergology & clinical immunology 20100101

Title: Multidrug resistance protein transporter and Ins(1,4,5)P₃-sensitive Ca²+-signaling involved in adenosine triphosphate export via Gq protein-coupled NK₂-receptor stimulation with neurokinin A.

Journal: Journal of pharmacological sciences 20100101

Title: Autocrine regulation of human sperm motility by tachykinins.

Journal: Reproductive biology and endocrinology : RB&E 20100101

Title: Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090801

Title: Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression.

Journal: Biochemical pharmacology 20090601

Title: Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] gamma2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice.

Journal: Brain research 20090519

Title: Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation.

Journal: The Journal of pharmacology and experimental therapeutics 20090401

Title: An extract (THC-002) of Ba-Wei-Die-Huang-Wan inhibits expression of tachykinins, and P2X3 and TRPV1 receptors, and inhibits ATP-induced detrusor overactivity in spontaneously hypertensive rats.

Journal: Neurourology and urodynamics 20090101

Title: NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.

Journal: Vascular pharmacology 20090101

Title: Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation.

Journal: American journal of physiology. Lung cellular and molecular physiology 20081201

Title: Neurokinin-A inhibits cell cycle activators in K562 cells and activates Smad 4 through a non-canonical pathway: a novel method in neural-hematopoietic axis.

Journal: Journal of neuroimmunology 20081115

Title: Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080701

Title: Neurokinin receptor modulation of respiratory activity in the rabbit.

Journal: The European journal of neuroscience 20080601

Title: Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.

Journal: The European journal of neuroscience 20080601

Title: Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses.

Journal: European journal of pharmacology 20080531

Title: Estrogen determines sex differences in airway responsiveness after allergen exposure.

Journal: American journal of respiratory cell and molecular biology 20080501

Title: Contractile properties of the pig bladder mucosa in response to neurokinin A: a role for myofibroblasts?

Journal: British journal of pharmacology 20080401

Title: Changes in the control of gastric motor activity during metamorphosis in the amphibian Xenopus laevis, with special emphasis on purinergic mechanisms.

Journal: The Journal of experimental biology 20080401

Title: Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080301

Title: Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.

Journal: Digestive diseases and sciences 20080101

Title: The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction.

Journal: Pulmonary pharmacology & therapeutics 20080101

Title: Capsaicin-sensitive nerves and neurokinins modulate non-neuronal nNOS expression in lung.

Journal: Respiratory physiology & neurobiology 20080101

Title: Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: Nerve growth factor enhances neurokinin A-induced airway responses and exhaled nitric oxide via a histamine-dependent mechanism.

Journal: Pulmonary pharmacology & therapeutics 20080101

Title: Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder.

Journal: Neurourology and urodynamics 20080101

Title: Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum.

Journal: Neuropeptides 20080101

Title: Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists.

Journal: European journal of pharmacology 20071222

Title: Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201

Title: Fluorometric immunoassay based on pH-sensitive dye-encapsulating liposomes and gramicidin channels.

Journal: Analytical biochemistry 20071015

Title: Intraluminal acid induces oesophageal shortening via capsaicin-sensitive neurokinin neurons.

Journal: Gut 20071001

Title: Distribution of neuroendocrine cells in the small and large intestines of the one-humped camel (Camelus dromedarius).

Journal: Neuropeptides 20071001

Title: Role for NK(1) and NK(2) receptors in the motor activity in mouse colon.

Journal: European journal of pharmacology 20070910

Title: Pelviureteric peristaltic contractions in diabetic rats.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20070801

Title: A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701

Title: A role for tachykinins in the regulation of human sperm motility.

Journal: Human reproduction (Oxford, England) 20070601

Title: Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction.

Journal: The Journal of allergy and clinical immunology 20070501

Title: Neurokinins enhance excitability in capsaicin-responsive DRG neurons.

Journal: Experimental neurology 20070501

Title: Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.

Journal: Journal of pharmacological sciences 20070501

Title: The effects of saltwater acclimation on neurotransmitters in the lingual salt glands of the estuarine crocodile, Crocodylus porosus.

Journal: Regulatory peptides 20070405

Title: Distribution of neurokinin A-like and serotonin immunoreactivities within the vertical lobe complex in Sepia officinalis.

Journal: Brain research 20070216

Title: Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.

Journal: Brain : a journal of neurology 20061201

Title: MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist.

Journal: European journal of pharmacology 20061107

Title: Circulating markers of prognosis and response to treatment in patients with midgut carcinoid tumours.

Journal: Gut 20061101

Title: Ontogeny of excitatory and inhibitory control of gastrointestinal motility in the African clawed frog, Xenopus laevis.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20061001

Title: Neurokinin3 receptor regulation of the airways.

Journal: Vascular pharmacology 20061001

Title: Regulation of the stimulant actions of neurokinin a and human hemokinin-1 on the human uterus: a comparison with histamine.

Journal: Biology of reproduction 20060901

Title: The inhibitory effects of local anesthetics on primary sensory nerve and parasympathetic nerve in rabbit eye.

Journal: Anesthesia and analgesia 20060901

Title: Contribution of Rho-kinase in human gallbladder contractions.

Journal: European journal of pharmacology 20060701

Title: Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma.

Journal: Respiratory medicine 20060601

Title: NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Nongenomic effects of progesterone on the contraction of muscle cells from the guinea pig colon.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20060501

Title: Substance P initiates NFAT-dependent gene expression in spinal neurons.

Journal: Journal of neurochemistry 20060401

Title: Depressed contractile responses to neurokinin A in idiopathic but not neurogenic overactive human detrusor muscle.

Journal: European urology 20060301

Title: Clinical-biochemical correlates of migraine attacks in rizatriptan responders and non-responders.

Journal: Cephalalgia : an international journal of headache 20060301

Title: Role of NK1 and NK2 receptors in mouse gastric mechanical activity.

Journal: British journal of pharmacology 20060201

Title: Rho kinase expression and its central role in ovine gallbladder contractions elicited by a variety of excitatory stimuli.

Journal: European journal of pharmacology 20051228

Title: Production of IL-1beta, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis.

Journal: American journal of physiology. Cell physiology 20051201

Title: Substance P, neurokinins A and B, and synthetic tachykinin peptides protect mesencephalic dopaminergic neurons in culture via an activity-dependent mechanism.

Journal: Molecular pharmacology 20051101

Title: Endobronchial adenosine monophosphate challenge causes tachykinin release in the human airway.

Journal: The Journal of allergy and clinical immunology 20050801

Title: The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.

Journal: British journal of pharmacology 20050701

Title: The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein.

Journal: The Journal of biological chemistry 20050603

Title: Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor.

Journal: European journal of pharmacology 20050601

Title: Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar rats.

Journal: Alcohol (Fayetteville, N.Y.) 20050601

Title: Impaired capsaicin and neurokinin-evoked colonic motility in inflammatory bowel disease.

Journal: Journal of gastroenterology and hepatology 20050501

Title: Tachykinins and tachykinin-receptors in the rat pineal gland.

Journal: The European journal of neuroscience 20050501

Title: Neurokinins and inflammatory cell iNOS expression in guinea pigs with chronic allergic airway inflammation.

Journal: American journal of physiology. Lung cellular and molecular physiology 20050401

Title: Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle.

Journal: European journal of pharmacology 20050221

Title: Neurokinin a is a main constituent of sensory neurons innervating the anterior segment of the eye.

Journal: Investigative ophthalmology & visual science 20050101

Title: GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cord.

Journal: Neuroscience 20050101

Title: Relationship between airway responsiveness to neurokinin A and methacholine in asthma.

Journal: Pulmonary pharmacology & therapeutics 20050101

Title: Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study.

Journal: European journal of histochemistry : EJH 20050101

Title: Involvement of Ca2+ signaling in tachykinin-mediated contractile responses in swine trachea.

Journal: Journal of biomedical science 20050101

Title: [Effect of natural tachykinins on the bile production in rats].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20050101

Title: [Structure-function organization of neurokinin A and neurokinin B molecules. III. A conformational study of glycine-monosubstituted analogues of neurokinins A and B].

Journal: Biofizika 20050101

Title: Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways.

Journal: American journal of respiratory and critical care medicine 20041101

Title: Ontogeny of the gut motility control system in zebrafish Danio rerio embryos and larvae.

Journal: The Journal of experimental biology 20041101

Title: Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis.

Journal: The Journal of pharmacology and experimental therapeutics 20041001

Title: Pharmacological evaluation of alpha and beta human tachykinin NK(2) receptor splice variants expressed in CHO cells.

Journal: European journal of pharmacology 20040924

Title: Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro.

Journal: BJU international 20040901

Title: Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma.

Journal: International archives of allergy and immunology 20040801

Title: Functional role of the Na+/H+ exchanger in the regulation of cerebral arteriolar tone in rats.

Journal: Journal of neurosurgery 20040801

Title: Influence of maturation on constrictive response to stimulation of C-fiber afferents in isolated guinea pig airways.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040701

Title: Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract.

Journal: American journal of veterinary research 20040701

Title: Seasonal changes of SP and NKA in frontal cortex, striatum and testes in the rat. Role of maternal pineal gland.

Journal: Peptides 20040601

Title: Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040501

Title: Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats.

Journal: Neuropharmacology 20040501

Title: Effects of TAK-637 on NK(1) receptor-mediated mechanisms regulating colonic secretion.

Journal: Toxicology and applied pharmacology 20040415

Title: Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.

Journal: Journal of pharmacological sciences 20040401

Title: Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits.

Journal: Pharmacology 20040301

Title: Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain.

Journal: European journal of pharmacology 20040223

Title: Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson's disease.

Journal: Current drug targets 20040201

Title: Role of sensory nerve peptides rather than mast cell histamine in paclitaxel hypersensitivity.

Journal: American journal of respiratory and critical care medicine 20040101

Title: Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients.

Journal: The European respiratory journal 20040101

Title: Neurokinin-1 receptors in the rat nucleus tractus solitarius: pre- and postsynaptic modulation of glutamate and GABA release.

Journal: Neuroscience 20040101

Title: Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord.

Journal: British journal of pharmacology 20031201

Title: Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles.

Journal: Biophysical journal 20031201

Title: Cholinergic transmission to colonic circular muscle of children with slow-transit constipation is unimpaired, but transmission via NK2 receptors is lacking.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20031201

Title: Similarities of SP-, NKA- and NKB-induced currents in rat dorsal root ganglion neurons.

Journal: Brain research 20031121

Title: Inhibition of human detrusor contraction by a urothelium derived factor.

Journal: The Journal of urology 20031101

Title: Investigation of neurokinin-2 and -3 receptors in the human and pig bladder.

Journal: BJU international 20031101

Title: PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031001

Title: Characterization of tachykinin NK2 receptor in the anterior pituitary gland.

Journal: Life sciences 20030926

Title: A role for tachykinins in female mouse and rat reproductive function.

Journal: Biology of reproduction 20030901

Title: Human tachykinin NK2 receptor: a comparative study of the colon and urinary bladder.

Journal: Clinical and experimental pharmacology & physiology 20030901

Title: Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.

Journal: Life sciences 20030829

Title: Miniaturization of fluorescence polarization receptor-binding assays using CyDye-labeled ligands.

Journal: Journal of biomolecular screening 20030801

Title: [Effect of substance K on the contractility of cardiomyocytes].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20030801

Title: Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration.

Journal: Brain research 20030725

Title: Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.

Journal: The European journal of neuroscience 20030601

Title: Pharmacological properties of peptides derived from an antibody against the tachykinin NK1 receptor for the neuropeptide substance P.

Journal: European journal of pharmacology 20030516

Title: Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation.

Journal: The Journal of clinical investigation 20030401

Title: Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction.

Journal: The Journal of allergy and clinical immunology 20030401

Title: Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes.

Journal: British journal of pharmacology 20030401

Title: Biologic activity of the tachykinins on lamb and sheep gallbladder.

Journal: Peptides 20030401

Title: Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.

Journal: Pharmacology, biochemistry, and behavior 20030101

Title: A tachykinin-like factor increases glutamate toxicity in rat cerebellar granule cells.

Journal: Neuropharmacology 20030101

Title: Mapping of neurokinin-like immunoreactivity in the human brainstem.

Journal: BMC neuroscience 20030101

Title: Effects of neurokinins on airway and alveolar eosinophil recruitment.

Journal: Experimental lung research 20030101

Title: SR 142801, a tachykinin NK(3) receptor antagonist, prevents beta(2)-adrenoceptor agonist-induced hyperresponsiveness to neurokinin A in guinea-pig isolated trachea.

Journal: Life sciences 20021206

Title: Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle.

Journal: Anesthesia and analgesia 20021201

Title: Neurokinin A and the neurohypophysial response to melatonin: in vitro studies.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201

Title: Mutations in the extracellular amino-terminal domain of the NK2 neurokinin receptor abolish cAMP signaling but preserve intracellular calcium responses.

Journal: The Journal of biological chemistry 20021101

Title: The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.

Journal: British journal of pharmacology 20021101

Title: Neurokinin-receptor-mediated depolarization of cortical neurons elicits an increase in glutamate release at excitatory synapses.

Journal: The European journal of neuroscience 20021101

Title: The primary structures and myotropic activities of two tachykinins isolated from the African clawed frog, Xenopus laevis.

Journal: Regulatory peptides 20021015

Title: Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.

Journal: Brain research 20021011

Title: Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease.

Journal: The Journal of pharmacology and experimental therapeutics 20020801

Title: Tachykinin-independent activity of capsaicin on in-vitro lamb detrusor.

Journal: The Journal of pharmacy and pharmacology 20020801

Title: Non-adrenergic non-cholinergic excitatory innervation in the airways: role of neurokinin-2 receptors.

Journal: Autonomic & autacoid pharmacology 20020801

Title: Effect of monensin on the levels of tachykinins and their processing enzyme activity in rat dorsal root ganglia.

Journal: Neuroscience letters 20020628

Title: Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma.

Journal: The European respiratory journal 20020601

Title: Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model.

Journal: Pharmacology 20020501

Title: Age differences in neurokinin A and substance P from the hypothalamus, pituitary, pineal gland, and striatum of the rat. Effect of exogenous melatonin.

Journal: Peptides 20020501

Title: Tachykinin-stimulated small bowel myoelectric pattern: sensitization by NO inhibition, reversal by neurokinin receptor blockade.

Journal: Regulatory peptides 20020415

Title: Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines.

Journal: Archives of surgery (Chicago, Ill. : 1960) 20020401

Title: Effect of tachykinins on ascending and descending reflex pathway in rat small intestine.

Journal: Acta pharmacologica Sinica 20020401

Title: Role of tachykinins in sephadex-induced airway hyperreactivity and inflammation in guinea pigs.

Journal: European journal of pharmacology 20020329

Title: Enhancement of neurokinin A-induced smooth muscle contraction in human urinary bladder by mucosal removal and phosphoramidon: relationship to peptidase inhibition.

Journal: European journal of pharmacology 20020308

Title: Cyclo-oxygenase- and capsaicin-sensitive afferent fibres affect Beta-adrenoceptor-evoked response in the rat urinary bladder.

Journal: Pharmacology 20020201

Title: Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.

Journal: The Journal of pharmacology and experimental therapeutics 20020101

Title: Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.

Journal: British journal of pharmacology 20020101

Title: In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum.

Journal: Neuroscience 20020101

Title: Role of cholinergic reflexes on the bronchoconstrictor reactivity to neurokinin a in allergic dogs.

Journal: Pulmonary pharmacology & therapeutics 20020101

Title: Activation of neurokinin-1 receptors promotes GABA release at synapses in the rat entorhinal cortex.

Journal: Neuroscience 20020101

Title: Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors.

Journal: Neuroscience 20020101

Title: 2-Aryl indole NK(1) antagonists: optimisation of the amide substituent.

Journal: Bioorganic & medicinal chemistry letters 20011203

Title: Endothelin-1 increases cholinergic nerve-mediated contraction of human bronchi via tachykinin synthesis induction.

Journal: British journal of pharmacology 20011201

Title: Presence of NK2 binding sites in the rat brain.

Journal: Journal of neurochemistry 20011201

Title: Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.

Journal: Life sciences 20011121

Title: Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene.

Journal: Neuroscience letters 20011102

Title: The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor.

Journal: The Journal of investigative dermatology 20011101

Title: Sources of calcium in neurokinin A-induced contractions of human colonic smooth muscle in vitro.

Journal: The American journal of gastroenterology 20011101

Title: Substance P and neurokinin levels are decreased in the cortex and hypothalamus of alcohol-preferring (P) rats.

Journal: Journal of studies on alcohol 20011101

Title: Interaction of Met297 in the seventh transmembrane segment of the tachykinin NK2 receptor with neurokinin A.

Journal: The Journal of biological chemistry 20011012

Title: Pronociceptive effects of nociceptin/orphanin FQ (13-17) at peripheral and spinal level in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: Nepadutant pharmacokinetics and dose-effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: Radioligand binding and functional characterisation of tachykinin receptors in chicken small intestine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20011001

Title: Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum.

Journal: Regulatory peptides 20010915

Title: The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states.

Journal: The Journal of biological chemistry 20010914

Title: The role of sensory neuropeptides in motor innervation of the hamster isolated urinary bladder.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010901

Title: Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20010801

Title: Tachykinin NK(2) receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study.

Journal: British journal of pharmacology 20010801

Title: Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease.

Journal: British journal of pharmacology 20010801

Title: Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010801

Title: Large veins in the Atlantic cod (Gadus morhua) and the rainbow trout (Oncorhynchus mykiss) are innervated by neuropeptide-containing nerves.

Journal: Anatomy and embryology 20010801

Title: Effect of calcitonin gene-related peptide (CGRP) on motility and on the release of substance P, neurokinin A, somatostatin and gastrin in the isolated perfused porcine antrum.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20010801

Title: Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue.

Journal: European journal of pharmacology 20010706

Title: Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.

Journal: Brain research bulletin 20010701

Title: The roles of the N-terminal portions of various tachykinins in promoting salivation.

Journal: Oral diseases 20010701

Title: Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010601

Title: The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection.

Journal: The Journal of clinical investigation 20010601

Title: An animal model to assess aversion to intra-oral capsaicin: increased threshold in mice lacking substance p.

Journal: Chemical senses 20010601

Title: Physiology of meningeal innervation: aspects and consequences of chemosensitivity of meningeal nociceptors.

Journal: Microscopy research and technique 20010415

Title: Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.

Journal: American journal of physiology. Cell physiology 20010401

Title: Tachykinin activation of human monocytes from patients with rheumatoid arthritis: in vitro and ex-vivo effects of cyclosporin A.

Journal: Neuropeptides 20010401

Title: Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.

Journal: European journal of pharmacology 20010216

Title: Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20010201

Title: The N-terminal domain of substance P is required for complete homologous desensitization but not phosphorylation of the rat neurokinin-1 receptor.

Journal: Neuropeptides 20010201

Title: Structure-activity relationships of neurokinin A (4-10) at the human tachykinin NK(2) receptor: the role of natural residues and their chirality.

Journal: Biochemical pharmacology 20010101

Title: Tachykinins contribute to nerve-mediated contractions in the human esophagus.

Journal: Gastroenterology 20010101

Title: Effect of tachykinins on airway function in cynomolgus monkeys.

Journal: Pulmonary pharmacology & therapeutics 20010101

Title: Bronchoconstrictor reactivity to NKA in allergic dogs: a comparison to histamine and methacholine.

Journal: Pulmonary pharmacology & therapeutics 20010101

Title: Involvement of spinal NK2 and NMDA receptors in aversive behavior induced by intra-arterial injection of capsaicin.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: NK2 tachykinin receptors mediate contraction of the pig intravesical ureter: tachykinin-induced enhancement of non-adrenergic non-cholinergic excitatory neurotransmission.

Journal: Neurourology and urodynamics 20010101

Title: Nitric oxide is generated in smooth muscle layer by neurokinin A and counteracts constriction in guinea pig airway.

Journal: Nitric oxide : biology and chemistry 20010101

Title: Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks.

Journal: Cephalalgia : an international journal of headache 20001201

Title: Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors.

Journal: Pancreas 20000401

Title: Acute and chronic effects of capsaicin in perfused rat muscle: the role of tachykinins and calcitonin gene-related peptide.

Journal: The Journal of pharmacology and experimental therapeutics 19981101

Title: p38 mitogen-activated protein kinase expression and activation in smooth muscle.

Journal: The American journal of physiology 19980801

Title: Nociceptive inhibition of migrating myoelectric complex by nitric oxide and monoaminergic pathways in the rat.

Journal: The American journal of physiology 19980301

Title: Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.

Journal: The Journal of pharmacology and experimental therapeutics 19970601

Title: Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis.

Journal: FEBS letters 19961216

Title: In vivo exposure to nitrogen dioxide (NO2) induces a decrease in calcitonin gene-related peptide (CGRP) and tachykinin immunoreactivity in guinea-pig peripheral airways.

Journal: The European respiratory journal 19960901

Title: The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity.

Journal: The Journal of biological chemistry 19960823

Title: Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.

Journal: The Journal of urology 19951001

Title: New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists.

Journal: Journal of medicinal chemistry 19950915

Title: Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin.

Journal: Journal of neurophysiology 19941001

Title: Cyclic hexapeptide NK-2 antagonists.

Journal: International journal of peptide and protein research 19940801

Title: The non-peptide tachykinin NK2 receptor antagonist SR 48968 interacts with human, but not rat, cloned tachykinin NK3 receptors.

Journal: Biochemical and biophysical research communications 19940215

Title: Expression of rat NK-2 (neurokinin A) receptor in E. coli.

Journal: Receptors & channels 19940101

Title: Conformational study of cyclo[Gln-Trp-Phe-Gly-Leu-Met] as NK-2 antagonist by NMR and molecular dynamics.

Journal: Journal of pharmaceutical and biomedical analysis 19940101

Title: Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea.

Journal: British journal of pharmacology 19931101

Title: Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor.

Journal: Biochemical and biophysical research communications 19930331

Title: Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

Journal: The Journal of biological chemistry 19921225

Title: Influence of (+/-)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus.

Journal: European journal of pharmacology 19921202

Title: Structural characterization of tachykinins (neuropeptide gamma, neurokinin A, and substance P) from a reptile, Alligator mississipiensis.

Journal: General and comparative endocrinology 19921101

Title: Nonadrenergic, noncholinergic contractile responses of the guinea pig hilar bronchus involve the preferential activation of tachykinin neurokinin2 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19920901

Title: Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor.

Journal: Journal of medicinal chemistry 19920710

Title: FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity.

Journal: The Journal of pharmacology and experimental therapeutics 19920701

Title: Molecular characterisation, expression and localisation of human neurokinin-3 receptor.

Journal: FEBS letters 19920324

Title: Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells.

Journal: FEBS letters 19920127

Title: A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.

Journal: Life sciences 19920101

Title: Studies of reflexogenic effects of capsaicin and neuropeptides on neural afferents in the dog parietal pericardium.

Journal: Neuropeptides 19911101

Title: Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea.

Journal: British journal of pharmacology 19910601

Title: Antagonists for the neurokinin NK-3 receptor evaluated in selective receptor systems.

Journal: Regulatory peptides 19901115

Title: Competitive antagonists discriminate between NK2 tachykinin receptor subtypes.

Journal: British journal of pharmacology 19900701

Title: Structure-activity study of neurokinins: antagonists for the neurokinin-2 receptor.

Journal: Pharmacology 19900101

Title: [Arg3]substance P and neurokinin A from chicken small intestine.

Journal: Regulatory peptides 19880201

Title: Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins.

Journal: European journal of pharmacology 19860605

Title: A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates.

Journal: The Journal of biological chemistry 19850815

Title: Neuromedin L: a novel mammalian tachykinin identified in porcine spinal cord.

Journal: Neuropeptides 19840301

Title: Synthesis and biological activities of neurokinin alpha and beta.

Journal: Biochemical and biophysical research communications 19840130

Title: Gerard NP, et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62.

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Tags:86933-74-6 Molecular Formula|86933-74-6 MDL|86933-74-6 SMILES|86933-74-6 Neurokinin A