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869884-78-6,MFCD22628873
Catalog No.:AA00GU39

869884-78-6 | Radezolid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$46.00   $32.00
- +
5mg
≥95%
in stock  
$199.00   $139.00
- +
10mg
≥95%
in stock  
$348.00   $243.00
- +
25mg
≥95%
in stock  
$762.00   $533.00
- +
50mg
in stock  
$1,183.00   $828.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU39
Chemical Name:
Radezolid
CAS Number:
869884-78-6
Molecular Formula:
C22H23FN6O3
Molecular Weight:
438.4548
MDL Number:
MFCD22628873
SMILES:
CC(=O)NC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)c1ccc(cc1)CNCc1cnn[nH]1
Properties
Computed Properties
 
Complexity:
647  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
1.1  

Downstream Synthesis Route

[1]Patent:WO2016/77818,2016,A1

Literature

Title: Improving known classes of antibiotics: an optimistic approach for the future.

Journal: Current opinion in pharmacology 20121001

Title: Antibiotics in development targeting protein synthesis.

Journal: Annals of the New York Academy of Sciences 20111201

Title: The 2009 Nobel Prize in Chemistry: Thomas A. Steitz and the structure of the ribosome.

Journal: The Yale journal of biology and medicine 20110601

Title: Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.

Journal: Bioorganic & medicinal chemistry letters 20081201

Title: Lemaire S, et al. Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila.

Title: Locke JB, et al. Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. Antimicrob Agents Chemother. 2010 Dec;54(12):5337-43.

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SDS
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