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870653-45-5,MFCD11114059
Catalog No.:AA004JAO

870653-45-5 | 4-(4-Phenoxybutoxy)-7h-furo[3,2-g]chromen-7-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$24.00   $17.00
- +
5mg
97%
in stock  
$57.00   $40.00
- +
10mg
97%
in stock  
$85.00   $60.00
- +
25mg
97%
in stock  
$144.00   $101.00
- +
50mg
97%
in stock  
$242.00   $170.00
- +
250mg
97%
in stock  
$702.00   $492.00
- +
1g
97%
in stock  
$1,900.00   $1,330.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004JAO
Chemical Name:
4-(4-Phenoxybutoxy)-7h-furo[3,2-g]chromen-7-one
CAS Number:
870653-45-5
Molecular Formula:
C21H18O5
Molecular Weight:
350.3646
MDL Number:
MFCD11114059
SMILES:
O=c1ccc2c(o1)cc1c(c2OCCCCOc2ccccc2)cco1
Properties
Properties
 
BP:
555.8°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
499  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
7  
XLogP3:
4.7  

Literature

Title: Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.

Journal: Bioorganic & medicinal chemistry letters 20121201

Title: Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.

Journal: American journal of physiology. Endocrinology and metabolism 20110801

Title: Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.

Journal: Bioorganic & medicinal chemistry letters 20101201

Title: 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3.

Journal: European journal of medicinal chemistry 20090501

Title: Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques.

Journal: Experimental biology and medicine (Maywood, N.J.) 20071101

Title: Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.

Journal: Molecular pharmacology 20051101

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SDS
Tags:870653-45-5 Molecular Formula|870653-45-5 MDL|870653-45-5 SMILES|870653-45-5 4-(4-Phenoxybutoxy)-7h-furo[3,2-g]chromen-7-one