Home Other Building Blocks 870823-12-4
870823-12-4,MFCD11616198
Catalog No.:AA00GU1K

870823-12-4 | Mk-0893

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$650.00   $455.00
- +
10mg
99%
1 week  
$955.00   $669.00
- +
50mg
99%
1 week  
$2,273.00   $1,591.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU1K
Chemical Name:
Mk-0893
CAS Number:
870823-12-4
Molecular Formula:
C32H27Cl2N3O4
Molecular Weight:
588.4805
MDL Number:
MFCD11616198
SMILES:
COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl
Properties
Computed Properties
 
Complexity:
877  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
6.8  

Literature

Title: Extra-helical binding site of a glucagon receptor antagonist.

Journal: Nature 20160512

Title: Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.

Journal: Journal of medicinal chemistry 20120712

Title: A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: Xiong Y, et al. Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1--(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-ylethyl}phenyl)carbonyl-β-alanine (MK-0893) for the treatment of type II diabetes.J Med Chem. 2012 Jul 12;

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