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Home Other Building Blocks 87679-71-8
87679-71-8,MFCD09842610
Catalog No.:AA004K7E

87679-71-8 | Trandolaprilat Monohydrate

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Purity
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Price(USD)
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5mg
2 weeks  
$1,929.00   $1,350.00
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25mg
2 weeks  
$4,225.00   $2,958.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA004K7E
Chemical Name:
Trandolaprilat Monohydrate
CAS Number:
87679-71-8
Molecular Formula:
C22H32N2O6
Molecular Weight:
420.4993
MDL Number:
MFCD09842610
SMILES:
C[C@@H](C(=O)N1[C@H]2CCCC[C@@H]2C[C@H]1C(=O)O)N[C@H](C(=O)O)CCc1ccccc1.O
Properties
Computed Properties
 
Complexity:
604  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
1.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:UNIVERSITYOFZURICH-US2007/237817,2007,A1Locationinpatent:Page/Pagecolumn20-21

[2]CurrentPatentAssignee:UNIVERSITYOFZURICH-US2007/237817,2007,A1Locationinpatent:Page/Pagecolumn21

[3]CurrentPatentAssignee:UNIVERSITYOFZURICH-US2007/237817,2007,A1Locationinpatent:Page/Pagecolumn21

[4]CurrentPatentAssignee:UNIVERSITYOFZURICH-US2007/237817,2007,A1Locationinpatent:Page/Pagecolumn21

[5]CurrentPatentAssignee:UNIVERSITYOFZURICH-US2007/237817,2007,A1Locationinpatent:Page/Pagecolumn21-22

[6]CurrentPatentAssignee:UNIVERSITYOFZURICH-US2007/237817,2007,A1Locationinpatent:Page/Pagecolumn22;23

[7]Thomsen,Ragnar;Rasmussen,HenrikB.;Linnet,Kristian[DrugMetabolismandDisposition,2014,vol.42,#1,p.126-133]

Literature

Title: Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril.

Journal: Biochemical pharmacology 20090401

Title: Quantification of trandolapril and its metabolite trandolaprilat in human plasma by liquid chromatography/tandem mass spectrometry using solid-phase extraction.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Protective effects of quinaprilat and trandolaprilat, active metabolites of quinapril and trandolapril, on hemolysis induced by lysophosphatidylcholine in human erythrocytes.

Journal: Biological & pharmaceutical bulletin 20030501

Title: Effects of an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitors on burst forming units-erythroid in chronic hemodialysis patients.

Journal: American journal of nephrology 20030101

Title: Trandolaprilat, an angiotensin-converting enzyme inhibitor, is not excreted in bile via an ATP-dependent active transporter (cMOAT).

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010501

Title: Compared properties of trandolapril, enalapril, and their diacid metabolites.

Journal: Journal of cardiovascular pharmacology 19940101

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SDS
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