Home Other Building Blocks 878141-96-9
878141-96-9,MFCD25976945
Catalog No.:AA00GT9D

878141-96-9 | 4-(2-{[5-Methyl-1-(naphthalen-2-yl)pyrazol-3-yl]oxy}ethyl)morpholine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$218.00   $152.00
- +
5mg
≥98%
in stock  
$622.00   $435.00
- +
10mg
≥98%
in stock  
$1,016.00   $711.00
- +
25mg
98%
in stock  
$2,245.00   $1,572.00
- +
50mg
98%
in stock  
$3,993.00   $2,795.00
- +
100mg
98%
in stock  
$7,140.00   $4,998.00
- +
250mg
98%
in stock  
$15,991.00   $11,194.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GT9D
Chemical Name:
4-(2-{[5-Methyl-1-(naphthalen-2-yl)pyrazol-3-yl]oxy}ethyl)morpholine
CAS Number:
878141-96-9
Molecular Formula:
C20H23N3O2
Molecular Weight:
337.4155
MDL Number:
MFCD25976945
SMILES:
Cc1cc(nn1c1ccc2c(c1)cccc2)OCCN1CCOCC1
Properties
Computed Properties
 
Complexity:
416  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
3.5  

Literature

Title: Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice.

Journal: The journal of pain : official journal of the American Pain Society 20121101

Title: Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).

Journal: Journal of medicinal chemistry 20121011

Title: Díaz JL, et al. Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2--methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxyethyl}morpholine (S1RA, E-52862). J Med Chem. 2012 Oct 11;55(19):8211-24.

Title: Romero L, et al. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. Br J Pharmacol. 2012 Aug;166(8):2289-306.

Title: Vidal-Torres A, et al. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. J Neurochem. 2014 Jan 3.

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Tags:878141-96-9 Molecular Formula|878141-96-9 MDL|878141-96-9 SMILES|878141-96-9 4-(2-{[5-Methyl-1-(naphthalen-2-yl)pyrazol-3-yl]oxy}ethyl)morpholine