89213-87-6,MFCD00076226
Catalog No.:AA00GS4J

89213-87-6 | ANP 1-28, HUMAN

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1mg
≥95%
in stock  
$549.00   $384.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GS4J
Chemical Name:
ANP 1-28, HUMAN
CAS Number:
89213-87-6
Molecular Formula:
C129H204F3N45O41S3
Molecular Weight:
3194.4672
MDL Number:
MFCD00076226
SMILES:
OC(=O)C(F)(F)F.CSCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCCNC(=N)N)[C@H](CC)C)C)CCC(=O)N)CO)CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CCCNC(=N)N)Cc1ccccc1)CO)CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)CC(C)C)CCCNC(=N)N)CCCNC(=N)N)CO)CO
Properties
Computed Properties
 
Complexity:
6940  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
24  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
214  
Hydrogen Bond Acceptor Count:
48  
Hydrogen Bond Donor Count:
53  
Isotope Atom Count:
0  
Rotatable Bond Count:
75  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-14.9  

Literature

Title: Intermittent infusions of carperitide or inotoropes in out-patients with advanced heart failure.

Journal: Journal of cardiology 20120501

Title: Multicenter trial of carperitide in patients with renal dysfunction undergoing cardiovascular surgery.

Journal: General thoracic and cardiovascular surgery 20120101

Title: Tako-Tsubo cardiomyopathy caused immediately following cesarean section delivery of triplets: a case report.

Journal: Gynecologic and obstetric investigation 20120101

Title: Results of low-dose human atrial natriuretic peptide infusion in nondialysis patients with chronic kidney disease undergoing coronary artery bypass grafting: the NU-HIT (Nihon University working group study of low-dose HANP Infusion Therapy during cardiac surgery) trial for CKD.

Journal: Journal of the American College of Cardiology 20110823

Title: Acute efficacy of combined therapy of carperitide and nicorandil for acute decompensated heart failure with left ventricular systolic dysfunction.

Journal: International journal of cardiology 20110602

Title: Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.

Journal: Human molecular genetics 20110415

Title: Predicting the success of noninvasive positive pressure ventilation in emergency room for patients with acute heart failure.

Journal: Journal of cardiology 20110101

Title: Comparison of nitrite compounds and carperitide for initial treatment of acute decompensated heart failure.

Journal: International heart journal 20110101

Title: Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis.

Journal: Critical care (London, England) 20110101

Title: Effects of continuous venovenous hemofiltration on the pharmacology of carperitide, a recombinant human atrial natriuretic peptide.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20100901

Title: Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats.

Journal: Journal of bioscience and bioengineering 20100601

Title: Effect of carperitide on plasma adiponectin levels in acute decompensated heart failure patients with diabetes mellitus.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20091201

Title: Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis.

Journal: Journal of cardiovascular pharmacology 20090901

Title: Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

Journal: Anesthesiology 20090401

Title: Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

Journal: Journal of hypertension 20090301

Title: Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression.

Journal: BMC molecular biology 20090101

Title: Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure: the PROTECT multicenter randomized controlled study.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20081101

Title: The efficacy of human atrial natriuretic peptide in patients with renal dysfunction undergoing cardiac surgery.

Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20081001

Title: Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.

Journal: JAMA 20080123

Title: Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20070701

Title: [Infusion therapy at outpatient clinic in chronic end-stage heart failure].

Journal: Journal of cardiology 20070501

Title: Investigation of the association between normal-tension glaucoma and single nucleotide polymorphisms in natriuretic peptide gene.

Journal: Korean journal of ophthalmology : KJO 20070301

Title: Effect of prophylactic bronchodilator treatment with i.v. carperitide on airway resistance and lung compliance after tracheal intubation.

Journal: British journal of anaesthesia 20060501

Title: Evaluation of CXCL9 and CXCL10 as circulating biomarkers of human cardiac allograft rejection.

Journal: BMC cardiovascular disorders 20060101

Title: Inhibition of aldosterone and endothelin-1 by carperitide was attenuated with more than 1 week of infusion in patients with congestive heart failure.

Journal: Journal of cardiovascular pharmacology 20051001

Title: Experimental study on myocardial protection by adjunct use of carperitide (hANP) in cardiac surgery.

Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20050201

Title: Synthetic human alpha-atrial natriuretic peptide improves the management of postoperative hypertension and renal dysfunction after the repair of abdominal aortic aneurysm.

Journal: Journal of cardiovascular pharmacology 20031101

Title: Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts.

Journal: Molecular and cellular biochemistry 20030601

Title: Atrial natriuretic factor and C-type natriuretic peptide induce retraction of human thyrocytes in monolayer culture via guanylyl cyclase receptors.

Journal: The Journal of endocrinology 20020401

Title: Human atrial natriuretic factor and renin-aldosterone in paracetamol induced fulminant hepatic failure.

Journal: Gut 19910101

Title: The isolation and characterisation of human atrial natriuretic factor produced as a fusion protein in Escherichia coli.

Journal: European journal of biochemistry 19880601

Title: Human atrial natriuretic factor prevents against norepinephrine-induced acute renal failure in the rat.

Journal: Klinische Wochenschrift 19860101

Title: Kohno M, et al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7.

Title: Kohno M, et al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004.

Title: Ballermann BJ, et al. Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli. J Clin Invest. 1985 Dec;76(6):2049-56.

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SDS
Tags:89213-87-6 Molecular Formula|89213-87-6 MDL|89213-87-6 SMILES|89213-87-6 ANP 1-28, HUMAN
Catalog No.: AA00GS4J
89213-87-6,MFCD00076226
89213-87-6 | ANP 1-28, HUMAN
Pack Size: 1mg
Purity: ≥95%
in stock
$549.00 $384.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00GS4J
Chemical Name: ANP 1-28, HUMAN
CAS Number: 89213-87-6
Molecular Formula: C129H204F3N45O41S3
Molecular Weight: 3194.4672
MDL Number: MFCD00076226
SMILES: OC(=O)C(F)(F)F.CSCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCCNC(=N)N)[C@H](CC)C)C)CCC(=O)N)CO)CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CCCNC(=N)N)Cc1ccccc1)CO)CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)N)CC(C)C)CCCNC(=N)N)CCCNC(=N)N)CO)CO
Properties
Complexity: 6940  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 24  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 214  
Hydrogen Bond Acceptor Count: 48  
Hydrogen Bond Donor Count: 53  
Isotope Atom Count: 0  
Rotatable Bond Count: 75  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -14.9  
Literature fold

Title: Intermittent infusions of carperitide or inotoropes in out-patients with advanced heart failure.

Journal: Journal of cardiology20120501

Title: Multicenter trial of carperitide in patients with renal dysfunction undergoing cardiovascular surgery.

Journal: General thoracic and cardiovascular surgery20120101

Title: Tako-Tsubo cardiomyopathy caused immediately following cesarean section delivery of triplets: a case report.

Journal: Gynecologic and obstetric investigation20120101

Title: Results of low-dose human atrial natriuretic peptide infusion in nondialysis patients with chronic kidney disease undergoing coronary artery bypass grafting: the NU-HIT (Nihon University working group study of low-dose HANP Infusion Therapy during cardiac surgery) trial for CKD.

Journal: Journal of the American College of Cardiology20110823

Title: Acute efficacy of combined therapy of carperitide and nicorandil for acute decompensated heart failure with left ventricular systolic dysfunction.

Journal: International journal of cardiology20110602

Title: Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.

Journal: Human molecular genetics20110415

Title: Predicting the success of noninvasive positive pressure ventilation in emergency room for patients with acute heart failure.

Journal: Journal of cardiology20110101

Title: Comparison of nitrite compounds and carperitide for initial treatment of acute decompensated heart failure.

Journal: International heart journal20110101

Title: Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis.

Journal: Critical care (London, England)20110101

Title: Effects of continuous venovenous hemofiltration on the pharmacology of carperitide, a recombinant human atrial natriuretic peptide.

Journal: Circulation journal : official journal of the Japanese Circulation Society20100901

Title: Atrial natriuretic peptide enhances recovery from ischemia/reperfusion-induced renal injury in rats.

Journal: Journal of bioscience and bioengineering20100601

Title: Effect of carperitide on plasma adiponectin levels in acute decompensated heart failure patients with diabetes mellitus.

Journal: Circulation journal : official journal of the Japanese Circulation Society20091201

Title: Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis.

Journal: Journal of cardiovascular pharmacology20090901

Title: Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

Journal: Anesthesiology20090401

Title: Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

Journal: Journal of hypertension20090301

Title: Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression.

Journal: BMC molecular biology20090101

Title: Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure: the PROTECT multicenter randomized controlled study.

Journal: Circulation journal : official journal of the Japanese Circulation Society20081101

Title: The efficacy of human atrial natriuretic peptide in patients with renal dysfunction undergoing cardiac surgery.

Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia20081001

Title: Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.

Journal: JAMA20080123

Title: Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.

Journal: The Journal of pharmacology and experimental therapeutics20070801

Title: Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure.

Journal: Circulation journal : official journal of the Japanese Circulation Society20070701

Title: [Infusion therapy at outpatient clinic in chronic end-stage heart failure].

Journal: Journal of cardiology20070501

Title: Investigation of the association between normal-tension glaucoma and single nucleotide polymorphisms in natriuretic peptide gene.

Journal: Korean journal of ophthalmology : KJO20070301

Title: Effect of prophylactic bronchodilator treatment with i.v. carperitide on airway resistance and lung compliance after tracheal intubation.

Journal: British journal of anaesthesia20060501

Title: Evaluation of CXCL9 and CXCL10 as circulating biomarkers of human cardiac allograft rejection.

Journal: BMC cardiovascular disorders20060101

Title: Inhibition of aldosterone and endothelin-1 by carperitide was attenuated with more than 1 week of infusion in patients with congestive heart failure.

Journal: Journal of cardiovascular pharmacology20051001

Title: Experimental study on myocardial protection by adjunct use of carperitide (hANP) in cardiac surgery.

Journal: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia20050201

Title: Synthetic human alpha-atrial natriuretic peptide improves the management of postoperative hypertension and renal dysfunction after the repair of abdominal aortic aneurysm.

Journal: Journal of cardiovascular pharmacology20031101

Title: Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts.

Journal: Molecular and cellular biochemistry20030601

Title: Atrial natriuretic factor and C-type natriuretic peptide induce retraction of human thyrocytes in monolayer culture via guanylyl cyclase receptors.

Journal: The Journal of endocrinology20020401

Title: Human atrial natriuretic factor and renin-aldosterone in paracetamol induced fulminant hepatic failure.

Journal: Gut19910101

Title: The isolation and characterisation of human atrial natriuretic factor produced as a fusion protein in Escherichia coli.

Journal: European journal of biochemistry19880601

Title: Human atrial natriuretic factor prevents against norepinephrine-induced acute renal failure in the rat.

Journal: Klinische Wochenschrift19860101

Title: Kohno M, et al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7.

Title: Kohno M, et al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004.

Title: Ballermann BJ, et al. Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli. J Clin Invest. 1985 Dec;76(6):2049-56.

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