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89785-84-2,MFCD00917472
Catalog No.:AA003UEX

89785-84-2 | Tazobactam sodium

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100mg
≥95%
in stock  
$46.00   $32.00
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250mg
≥95%
in stock  
$95.00   $66.00
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1g
≥ 93% (Assay)
in stock  
$122.00   $86.00
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5g
≥ 93% (Assay)
in stock  
$334.00   $234.00
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25g
≥ 93% (Assay)
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$1,303.00   $912.00
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100g
≥ 93% (Assay)
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$4,750.00   $3,325.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003UEX
Chemical Name:
Tazobactam sodium
CAS Number:
89785-84-2
Molecular Formula:
C10H11N4NaO5S
Molecular Weight:
322.2729
MDL Number:
MFCD00917472
SMILES:
[O-]C(=O)[C@@H]1N2C(=O)C[C@H]2S(=O)(=O)[C@@]1(C)Cn1ccnn1.[Na+]
Properties
Properties
 
Form:
Solid  
MP:
>147℃ dec.  
Storage:
-20 ℃;Keep in dry area;  

Computed Properties
 
Complexity:
579  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
7  
Rotatable Bond Count:
3  

Literature

Title: Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli.

Journal: Drugs 20140101

Title: A case of severe toxicity during coadministration of vincristine and piperacillin: are drug transporters involved in vincristine hypersensitivity and drug-drug interactions?

Journal: Journal of pediatric hematology/oncology 20121101

Title: Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects.

Journal: The Journal of antimicrobial chemotherapy 20121001

Title: Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice.

Journal: World journal of surgery 20120901

Title: AmpC β-lactamases in nosocomial isolates of Klebsiella pneumoniae from India.

Journal: The Indian journal of medical research 20120801

Title: Pseudomonas aeruginosa septic arthritis of knee after intra-articular ozone injection.

Journal: The new microbiologica 20120701

Title: Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study.

Journal: Critical care medicine 20120501

Title: Treating pneumonia in critical care in the United Kingdom following failure of initial antibiotic: a cost-utility analysis comparing meropenem with piperacillin/tazobactam.

Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20120401

Title: Bubbles in the urinary bladder.

Journal: The Netherlands journal of medicine 20120101

Title: Clostridium perfringens infection complicating periprosthetic fracture fixation about the hip: successful treatment with early aggressive debridement.

Journal: Hip international : the journal of clinical and experimental research on hip pathology and therapy 20120101

Title: [Determination of target compounds in cefoperazone sodium and tazobactam sodium for injection by capillary electrophoresis].

Journal: Se pu = Chinese journal of chromatography 20120101

Title: Protective effect of citropin 1.1 and tazobactam-piperacillin against oxidative damage and lethality in mice models of gram-negative sepsis.

Journal: The Journal of surgical research 20111201

Title: Biliary tract infection caused by Vibrio fluvialis in an immunocompromised patient.

Journal: Infection 20111001

Title: Antibiotic utilization and Pseudomonas aeruginosa resistance in intensive care units.

Journal: The new microbiologica 20110701

Title: Severe human parechovirus sepsis beyond the neonatal period.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20110501

Title: In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae.

Journal: Diagnostic microbiology and infectious disease 20110501

Title: Piperacillin/tazobactam monotherapy versus piperacillin/tazobactam plus amikacin as initial empirical therapy for febrile neutropenia in children with acute leukemia.

Journal: Pediatric hematology and oncology 20110501

Title: Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry.

Journal: The Journal of biological chemistry 20110422

Title: Drug fever due to piperacillin/tazobactam loaded into bone cement.

Journal: Journal of Korean medical science 20110201

Title: [Perioperative antibiotic prophylaxis in radical retropubic prostatectomy: a randomised pilot study of perioperative and postoperative administration].

Journal: Aktuelle Urologie 20110101

Title: Salmonella enteritidis liver abscess.

Journal: Annals of hepatology 20110101

Title: Necrotizing fasciitis of the breast: a case managed without mastectomy.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101

Title: Delayed-type hypersensitivity reaction to piperacillin/tazobactam in a patient with an infected total knee replacement.

Journal: The Journal of bone and joint surgery. British volume 20101101

Title: Tazobactam/piperacillin for moderate-to-severe pneumonia in patients with risk for aspiration: comparison with imipenem/cilastatin.

Journal: Pulmonary pharmacology & therapeutics 20101001

Title: Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae.

Journal: The Journal of antimicrobial chemotherapy 20100901

Title: In vitro selection of ertapenem and piperacillin/tazobactam-resistant strains of Bacteroides fragilis and analysis of their virulence in gnotobiotic mice.

Journal: Journal of chemotherapy (Florence, Italy) 20100801

Title: Right atrial thrombus in a six- year- old Indian boy with metabolic syndrome.

Journal: Journal of pediatric endocrinology & metabolism : JPEM 20100601

Title: Daily serum piperacillin monitoring is advisable in critically ill patients.

Journal: International journal of antimicrobial agents 20100501

Title: Proteomic analysis of Escherichia coli with experimentally induced resistance to piperacillin/tazobactam.

Journal: Research in microbiology 20100501

Title: An unusual case of septic shock in a geriatric patient.

Journal: Connecticut medicine 20100301

Title: Septicemic melioidosis.

Journal: The Journal of the Association of Physicians of India 20100201

Title: In-vitro efficacy of synergistic antibiotic combinations in multidrug resistant Pseudomonas aeruginosa strains.

Journal: Yonsei medical journal 20100101

Title: Comparative in vitro study of the antimicrobial activities of different commercial antibiotic products for intravenous administration.

Journal: BMC clinical pharmacology 20100101

Title: Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators.

Journal: Critical care (London, England) 20100101

Title: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock.

Journal: Critical care (London, England) 20100101

Title: Nosocomial transmission of Cupriavidus pauculus during extracorporeal membrane oxygenation.

Journal: ASAIO journal (American Society for Artificial Internal Organs : 1992) 20100101

Title: In vitro synergy studies based on tazobactam/piperacillin against clinical isolates of metallo-beta-lactamase-producing Pseudomonas aeruginosa.

Journal: The Journal of antimicrobial chemotherapy 20091101

Title: Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulation and steady-state pharmacokinetic data from hospitalized patients.

Journal: The Annals of pharmacotherapy 20091101

Title: Comparative pharmacodynamics of intermittent and prolonged infusions of piperacillin/tazobactam using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients.

Journal: The Annals of pharmacotherapy 20091101

Title: Expanded studies of piperacillin/tazobactam formulations: variations among branded product lots and assessment of 46 generic lots.

Journal: Diagnostic microbiology and infectious disease 20091101

Title: [Post antibiotic, post beta-lactamase inhibitor and post antibiotic sub-MIC effect of ceftriaxone/tazobactam on beta-lactamase-producing Escherichia coli in vitro].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20091101

Title: Epidural abscess and meningitis, a complication of spinal anesthesia in a bacteraemic patient.

Journal: JPMA. The Journal of the Pakistan Medical Association 20090801

Title: Treatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient.

Journal: Transplant infectious disease : an official journal of the Transplantation Society 20090601

Title: Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infections.

Journal: Diagnostic microbiology and infectious disease 20090601

Title: First identification of class A carbapenemase-producing Klebsiella pneumoniae in the Republic of Ireland.

Journal: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20090402

Title: [Fournier's gangrene caused by Streptococcus agalactiae in a non-pregnant woman].

Journal: Enfermedades infecciosas y microbiologia clinica 20090401

Title: Clostridium perfringens liver abscess after pancreatic resection.

Journal: Surgical infections 20090401

Title: Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence.

Journal: Journal of the American Chemical Society 20090218

Title: Pylephlebitis after a duodenal ulcer in a patient with metastasised colon carcinoma treated with chemotherapy and bevacizumab: a case report.

Journal: The Netherlands journal of medicine 20090201

Title: [Clinical effects and safety of piperacillin/tazobactam in treating neutropenic febrile patients with malignant hematopathy].

Journal: Zhonghua yi xue za zhi 20090106

Title: High performance liquid chromatographic determination of plasma free and total tazobactam and piperacillin.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090101

Title: Acute generalized exanthematous pustulosis: a rare clinical entity with use of piperacillin/tazobactam.

Journal: American journal of therapeutics 20090101

Title: In vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli.

Journal: The new microbiologica 20090101

Title: [Evaluation of occurrence of Alcaligenes faecalis in clinical samples of patients of the university hospital in Bydgoszcz].

Journal: Medycyna doswiadczalna i mikrobiologia 20090101

Title: Ertapenem versus piperacillin/tazobactam for the treatment of complicated infections: a meta-analysis of randomized controlled trials.

Journal: BMC infectious diseases 20090101

Title: Cost-effectiveness evaluation of ertapenem versus piperacillin/tazobactam in the treatment of complicated intraabdominal infections accounting for antibiotic resistance.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101

Title: Comparison of the effect of ciprofloxacin and Tazocin on the incidence of meticillin-resistant Staphylococcus aureus (MRSA) in an Intensive Care Unit.

Journal: International journal of antimicrobial agents 20081201

Title: Evaluating the ototoxicity of topical piperacillin-tazobactam.

Journal: International journal of pediatric otorhinolaryngology 20081201

Title: Pharmacokinetic/pharmacodynamic modeling to predict in vivo effectiveness of various dosing regimens of piperacillin/tazobactam and piperacillin monotherapy against gram-negative pulmonary isolates from patients managed in intensive care units in 2002.

Journal: Clinical therapeutics 20081201

Title: False positivity of the Aspergillus galactomannan Platelia ELISA because of piperacillin/tazobactam treatment: does it represent a clinical problem?

Journal: The Journal of antimicrobial chemotherapy 20081101

Title: Serological studies of piperacillin antibodies.

Journal: Transfusion 20081101

Title: Dacryocystitis: an unusual form of Mucorales infection.

Journal: The Journal of the Kentucky Medical Association 20081101

Title: Antimicrobial susceptibility of well-characterised multiresistant CTX-M-producing Escherichia coli: failure of automated systems to detect resistance to piperacillin/tazobactam.

Journal: International journal of antimicrobial agents 20081001

Title: Evaluation of sensitivity of different organisms to cefepime and tazobactum (megapime XP) in comparison to cefepime and ceftazidime.

Journal: Journal of the Indian Medical Association 20080901

Title: Efficacy and safety of doripenem versus piperacillin/tazobactam in nosocomial pneumonia: a randomized, open-label, multicenter study.

Journal: Current medical research and opinion 20080701

Title: Suspected drug reaction with piperacillin/tazobactam, in a premature infant.

Journal: British journal of clinical pharmacology 20080601

Title: Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia.

Journal: Critical care medicine 20080501

Title: Continuous infusion of beta-lactams in the intensive care unit--best way to hit the target?

Journal: Critical care medicine 20080501

Title: Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence.

Journal: Biochemistry 20080401

Title: Piperacillin/tazobactam-induced Sweet syndrome in a patient with chronic lymphocytic leukemia and autoimmune cholangitis.

Journal: The American Journal of dermatopathology 20080401

Title: Piperacillin/tazobactam-heteroresistant Pseudomonas aeruginosa from urinary infection, successfully treated by piperacillin/tazobactam.

Journal: The Journal of antimicrobial chemotherapy 20080301

Title: 5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.

Journal: Bioorganic & medicinal chemistry 20080215

Title: False-positive Aspergillus antigen testing due to application of piperacillin/tazobactam--is it still an issue?

Journal: Diagnostic microbiology and infectious disease 20080101

Title: Irreproducible piperacillin/tazobactam minimum inhibitory concentrations in microdilution tests with Escherichia coli strains.

Journal: International journal of antimicrobial agents 20080101

Title: Tachyplesin III and granulocyte-colony stimulating factor enhance the efficacy of tazobactam/piperacillin in a neutropenic mouse model of polymicrobial peritonitis.

Journal: Peptides 20080101

Title: Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitis.

Journal: Critical care medicine 20080101

Title: Occurrence of ESBL & Amp-C beta-lactamases & susceptibility to newer antimicrobial agents in complicated UTI.

Journal: The Indian journal of medical research 20080101

Title: Incidence and impact on clinical outcome of infections with piperacillin/tazobactam resistant Escherichia coli in ICU: a retrospective study.

Journal: BMC infectious diseases 20080101

Title: Primary psoas abscess in a patient affected by acquired immunodeficiency syndrome: a rare case according to the reviewed literature.

Journal: La Clinica terapeutica 20080101

Title: [Treatment of a septic shock due to multiresistant Acinetobacter baumannii with tigecycline in combination].

Journal: Annales francaises d'anesthesie et de reanimation 20071201

Title: Serum piperacillin/tazobactam pharmacokinetics in a morbidly obese individual.

Journal: The Annals of pharmacotherapy 20071001

Title: Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase.

Journal: Biochemistry 20070807

Title: Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanate.

Journal: The Journal of antimicrobial chemotherapy 20070801

Title: Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit.

Journal: The Journal of trauma 20070801

Title: New primary management for appendiceal masses in children: laparoscopic drainage.

Journal: Journal of laparoendoscopic & advanced surgical techniques. Part A 20070801

Title: Control of multi-resistant bacteria and ventilator-associated pneumonia: is it possible with changes in antibiotics?

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20070801

Title: Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.

Journal: Biochemistry 20070724

Title: Appropriate comparators for alternate dosing strategies.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070715

Title: An improved high-performance liquid chromatographic method with a solid-phase extraction for the determination of piperacillin and tazobactam: application to pharmacokinetic study of different dosage in Chinese healthy volunteers.

Journal: Biomedical chromatography : BMC 20070701

Title: In vitro efficacy of ceftriaxone/sulbactam against Escherichia coli isolates producing CTX-M-15 extended-spectrum beta-lactamase.

Journal: The Journal of antimicrobial chemotherapy 20070701

Title: Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement.

Journal: The Journal of antimicrobial chemotherapy 20070701

Title: Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system.

Journal: Indian journal of medical microbiology 20070701

Title: [Peritonsillar abscess: a life threatening disease--diagnostic and therapeutic aspects].

Journal: Laryngo- rhino- otologie 20070501

Title: [Infection with Aeromonas hydrophila after use of leeches (Hirudo medicinalis) in a free microvascular osteo-(myo-)cutaneous flap--suggestions for successful management].

Journal: Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... 20070401

Title: Successful treatment and limb salvage of mucor necrotizing fasciitis after kidney transplantation with posaconazole.

Journal: Hawaii medical journal 20070301

Title: In vitro activities of various piperacillin and sulbactam combinations against bacterial pathogens isolated from Intensive Care Units in Taiwan: SMART 2004 programme data.

Journal: International journal of antimicrobial agents 20070201

Title: Experience with the use of piperacillin-tazobactam in pediatric non-renal solid organ transplantation.

Journal: Pediatric transplantation 20070201

Title: Differences in the changes in resistance patterns to third- and fourth-generation cephalosporins and piperacillin/tazobactam among Klebsiella pneumoniae and Escherichia coli clinical isolates following a restriction policy in a Greek tertiary care hospital.

Journal: International journal of antimicrobial agents 20070101

Title: Enterobacter endophthalmitis: treatment with intravitreal tazobactam - piperacillin.

Journal: Indian journal of ophthalmology 20070101

Title: Clinical case of the month. A 48-year-old man with a non-healing wound.

Journal: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20070101

Title: Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection.

Journal: Antimicrobial agents and chemotherapy 20061101

Title: [Hepatic abscess due to Klebsiella pneumoniae in an Asian immigrant].

Journal: Enfermedades infecciosas y microbiologia clinica 20061101

Title: Case-control comparison of at-home to total hospital care for autologous stem-cell transplantation for hematologic malignancies.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061020

Title: Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.

Journal: Journal of the American Chemical Society 20061011

Title: Comparison of piperacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 h for treatment of nosocomial pneumonia.

Journal: Respiratory medicine 20060901

Title: Amphibian peptides prevent endotoxemia and bacterial translocation in bile duct-ligated rats.

Journal: Critical care medicine 20060901

Title: Can the ravages of uncontrolled systemic inflammatory response be regulated by amphibian antimicrobial peptides?

Journal: Critical care medicine 20060901

Title: Influence of culture site-specific MIC distributions on the pharmacokinetic and pharmacodynamic properties of piperacillin/tazobactam and piperacillin: a data analysis.

Journal: Clinical therapeutics 20060701

Title: Antimicrobial resistance in gram-positive bacteria.

Journal: The American journal of medicine 20060601

Title: [Antibiotic prophylaxis in cesarean section -- piperacillin versus piperacillin/tazobactam in 300 cesarean sections].

Journal: Zentralblatt fur Gynakologie 20060601

Title: Piperacillin/tazobactam vs imipenem/cilastatin in the treatment of nosocomial pneumonia--a double blind prospective multicentre study.

Journal: Infection 20060601

Title: Pharmacoeconomics of continuous versus intermittent infusion of piperacillin-tazobactam for the treatment of complicated intraabdominal infection.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060415

Title: Piperacillin-tazobactam monotherapy in high-risk febrile and neutropenic cancer patients.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20060301

Title: Picture of the month. Infected urachal cyst.

Journal: Archives of pediatrics & adolescent medicine 20060301

Title: Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials.

Journal: The Journal of antimicrobial chemotherapy 20060201

Title: Piperacillin/tazobactam vs ceftazidime in the treatment of neutropenic fever in patients with acute leukemia or following autologous peripheral blood stem cell transplantation: a prospective randomized trial.

Journal: Bone marrow transplantation 20060201

Title: [The combination effects of antibacterial agents against clinical isolated multiple-drug resistant Pseudomonas aeruginosa].

Journal: The Japanese journal of antibiotics 20060201

Title: Efficiency of tazobactam/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneum.

Journal: Shock (Augusta, Ga.) 20060101

Title: Clinical experience with three combination regimens for the treatment of high-risk febrile neutropenia.

Journal: Annals of the Academy of Medicine, Singapore 20060101

Title: Detection of bacterial strains producing sulbactam- or tazobactam-sensitive beta-lactamases by the use of disks containing the inhibitors alone instead of combining them with antibiotics.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20060101

Title: Piperacillin/tazobactam in treatment of brain abscess.

Journal: Scandinavian journal of infectious diseases 20060101

Title: In-vitro evaluation of 'piperacillin and tazobactum' combination in a tertiary-care hospital--a preliminary study.

Journal: Indian journal of pathology & microbiology 20060101

Title: Elimination of piperacillin and tazobactam by renal replacement therapies with AN69 and polysulfone hemofilters: evaluation of the sieving coefficient.

Journal: Blood purification 20060101

Title: Liver abscess after radiofrequency ablation of tumors in patients with a biliary tract procedure.

Journal: Gastroenterologie clinique et biologique 20060101

Title: Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function.

Journal: Neurology 20051213

Title: Pseudomonal sepsis with subcutaneous nodules in an HIV-infected individual with high CD4 counts.

Journal: The Journal of infection 20051201

Title: High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.

Journal: The Journal of biological chemistry 20051014

Title: Quantitation and stability of piperacillin and tazobactam in plasma and ultrafiltrate from patients undergoing continuous venovenous hemofiltration by HPLC.

Journal: Biomedical chromatography : BMC 20051001

Title: Fever, pulmonary haemorrhage, and acute renal failure in a young girl.

Journal: Hong Kong medical journal = Xianggang yi xue za zhi 20051001

Title: Shelf lives of aseptically prepared medicines--stability of piperacillin/tazobactam in PVC and non-PVC bags.

Journal: Journal of pharmaceutical and biomedical analysis 20050901

Title: Index of suspicion.

Journal: Pediatrics in review 20050901

Title: Group C streptococcal sepsis complicating Fournier gangrene.

Journal: Southern medical journal 20050901

Title: Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection.

Journal: The Journal of antimicrobial chemotherapy 20050801

Title: [Dynamic analysis of drug resistance of Pseudomonas aeruginosa in laboratory and clinical two-drug regimen].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050801

Title: Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial.

Journal: British journal of haematology 20050701

Title: In vitro activity of ceftriaxone plus tazobactam against members of Enterobacteriaceae.

Journal: The Journal of the Association of Physicians of India 20050701

Title: Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model.

Journal: The Journal of antimicrobial chemotherapy 20050601

Title: Antibacterial susceptibility of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli.

Journal: The Israel Medical Association journal : IMAJ 20050501

Title: Imipenem/cilastatin versus piperacillin/tazobactam plus amikacin for empirical therapy in febrile neutropenic patients: results of the COSTINE study.

Journal: Current medical research and opinion 20050501

Title: [Preliminary study on the release of DNA from Pseudomona aeruginosa induced by piperacillin/tazobactam in vitro].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20050401

Title: Severe intra-abdominal infection due to Streptococcus Milleri following adjustable gastric banding.

Journal: Obesity surgery 20050401

Title: A comparison of intravitreal piperacillin/tazobactam with ceftazidime in experimental Pseudomonas aeruginosa endophthalmitis.

Journal: Experimental eye research 20050301

Title: Influence of renal function on the pharmacokinetics of piperacillin/tazobactam in intensive care unit patients during continuous venovenous hemofiltration.

Journal: Journal of clinical pharmacology 20050201

Title: Simultaneous analysis of piperacillin and tazobactam in rabbits: application to pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20050101

Title: The efficacy of piperacillin/tazobactam in experimental Pseudomonas aeruginosa endophthalmitis: a histopathological and microbiological evaluation.

Journal: Current eye research 20050101

Title: Comparison of antimicrobial resistance of Acinetobacter baumannii clinical isolates from Shanghai and Hong Kong.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101

Title: Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.

Journal: Journal of medicinal chemistry 20041216

Title: Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant.

Journal: Biochemistry 20041109

Title: Piperacillin-tazobactam and netilmicin as a safe and efficacious empirical treatment of febrile neutropenic children.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20041001

Title: Beta-lactamase inhibitors: evolving compounds for evolving resistance targets.

Journal: Expert opinion on investigational drugs 20041001

Title: Effect of subinhibitory concentration of piperacillin/tazobactam on Pseudomonas aeruginosa.

Journal: Journal of medical microbiology 20040901

Title: In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor.

Journal: The Journal of antimicrobial chemotherapy 20040801

Title: Empirical antibiotic treatment with piperacillin-tazobactam in patients with microbiologically-documented biliary tract infections.

Journal: World journal of gastroenterology 20040801

Title: Randomized comparison of piperacillin/tazobactam versus imipenem/cilastatin in the treatment of patients with intra-abdominal infection.

Journal: Asian journal of surgery 20040701

Title: Tazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition.

Journal: The Journal of biological chemistry 20040507

Title: Piperacillin/tazobactam-induced acute delirium in a peritoneal dialysis patient.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040501

Title: Exploring the effectiveness of tazobactam against ceftazidime resistant Escherichia coli: insights from the comparison between susceptibility testing and beta-lactamase inhibition.

Journal: FEMS microbiology letters 20040501

Title: Impact of tazobactam pharmacokinetics on the antimicrobial effect of piperacillin-tazobactam combinations.

Journal: International journal of antimicrobial agents 20040501

Title: In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae.

Journal: Diagnostic microbiology and infectious disease 20040501

Title: Effect of the increasing use of piperacillin/tazobactam on the incidence of vancomycin-resistant enterococci in four academic medical centers.

Journal: Infection control and hospital epidemiology 20040501

Title: Serum bactericidal activity of piperacillin/tazobactam against Staphylococcus aureus, piperacillin-susceptible and piperacillin-resistant Escherichia coli and Pseudomonas aeruginosa.

Journal: Chemotherapy 20040401

Title: Safety evaluation of piperacillin/tazobactam in very low birth weight infants.

Journal: Journal of chemotherapy (Florence, Italy) 20040401

Title: Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.

Journal: Bioorganic & medicinal chemistry letters 20040308

Title: Increase in the rate of nosocomial Clostridium difficile-associated diarrhoea during shortages of piperacillin-tazobactam and piperacillin.

Journal: The Journal of antimicrobial chemotherapy 20040301

Title: Cefotaximases (CTX-M-ases), an expanding family of extended-spectrum beta-lactamases.

Journal: Canadian journal of microbiology 20040301

Title: [Pyogenic sacroiliitis complicated by iliopsoas muscle abscess].

Journal: Recenti progressi in medicina 20040301

Title: Meropenem plus amikacin versus piperacillin-tazobactam plus netilmicin as empiric therapy for high-risk febrile neutropenia in children.

Journal: Pediatric hematology and oncology 20040301

Title: Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structure.

Journal: Biochemistry 20040203

Title: Vancomycin does not benefit persistently febrile neutropenic people with cancer.

Journal: Cancer treatment reviews 20040201

Title: Tazobactam-induced haemolytic anaemia, possibly caused by non-immunological adsorption of IgG onto patient's red cells.

Journal: Transfusion medicine (Oxford, England) 20040201

Title: Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis.

Journal: Biochemical and biophysical research communications 20040116

Title: Evaluation of outpatient treatment with ertapenem in a double blind controlled clinical trial of complicated skin/skin structure infections.

Journal: The Journal of infection 20040101

Title: [Thoracic wall crossing (pseudo-?) tumor in a child: abscess-forming thoracic actinomycosis caused by Actinomyces meyeri et israeli].

Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 20040101

Title: Once-daily oral levofloxacin monotherapy versus piperacillin/tazobactam three times a day: a randomized controlled multicenter trial in patients with febrile neutropenia.

Journal: International journal of hematology 20040101

Title: Determination of nontoxic concentrations of piperacillin/tazobactam for intravitreal application. An electroretinographic, histopathologic and morphometric analysis.

Journal: Ophthalmic research 20040101

Title: [Antibiotic prophylaxis in laparotomic and laparoscopic cholecystectomy].

Journal: Chirurgia italiana 20040101

Title: [Antibiotic susceptibility and occurrence of ESBL in Pseudomonas aeruginosa strains isolated from different clinical specimens].

Journal: Medycyna doswiadczalna i mikrobiologia 20040101

Title: Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.

Journal: The Journal of biological chemistry 20031226

Title: False positive test for aspergillus antigenemia related to concomitant administration of piperacillin and tazobactam.

Journal: The New England journal of medicine 20031211

Title: Following the reactions of mechanism-based inhibitors with beta-lactamase by Raman crystallography.

Journal: Biochemistry 20031125

Title: Argentinean collaborative multicenter study on the in vitro comparative activity of piperacillin-tazobactam against selected bacterial isolates recovered from hospitalized patients.

Journal: Diagnostic microbiology and infectious disease 20031101

Title: Intracameral antibiotic agents for endophthalmitis prophylaxis: a pharmacokinetic model.

Journal: Journal of cataract and refractive surgery 20030901

Title: Nosocomial bacteremia and catheter infection by Bacillus cereus in an immunocompetent patient.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20030901

Title: Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.

Journal: Platelets 20030801

Title: Risk factors for piperacillin/tazobactam-resistant Escherichia coli in ICU patients: a clinical study.

Journal: Intensive care medicine 20030701

Title: Positive direct antiglobulin tests and haemolytic anaemia following therapy with the beta-lactamase inhibitor, tazobactam, may also be associated with non-immunologic adsorption of protein onto red blood cells.

Journal: Vox sanguinis 20030701

Title: [Phenotypes of beta-lactam resistance in the genus Aeromonas].

Journal: Pathologie-biologie 20030701

Title: Piperacillin-tazobactam is more effective than ceftriaxone plus gentamicin in febrile neutropenic patients with hematological malignancies: a randomized comparison.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20030601

Title: Penetration of piperacillin and tazobactam into pneumonic human lung tissue measured by in vivo microdialysis.

Journal: British journal of clinical pharmacology 20030601

Title: Efficacy of ertapenem in the treatment of serious infections caused by Enterobacteriaceae: analysis of pooled clinical trial data.

Journal: The Journal of antimicrobial chemotherapy 20030501

Title: Role of pharmacodynamics in designing dosage regimens for beta-lactams.

Journal: Connecticut medicine 20030501

Title: [beta-Lactamase-inhibitor combinations].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030301

Title: Sciatic nerve palsy as presenting sign of a perianal abscess.

Journal: Joint, bone, spine : revue du rhumatisme 20030201

Title: [Carbapenem antibiotic ertapenem in the treatment of extrahospital intraabdominal infections].

Journal: Khirurgiia 20030101

Title: Ertapenem once a day versus piperacillin-tazobactam every 6 hours for treatment of acute pelvic infections: a prospective, multicenter, randomized, double-blind study.

Journal: Infectious diseases in obstetrics and gynecology 20030101

Title: [Pharmacokinetics of antibiotics in inflamed and healthy lung tissue].

Journal: Wiener medizinische Wochenschrift (1946) 20030101

Title: [New Beta-lactam agent in the treatment of intra-abdominal sepsis: double blind and randomized stage III study of ertapenem versus piperacillin/tazobactam].

Journal: Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 20030101

Title: Postoperative infection with group A beta-hemolytic Streptococcus after blepharoplasty.

Journal: American journal of ophthalmology 20021201

Title: [Initial empirical antimicrobial therapy with piperacillin/tazobactam in intra-abdominal infections due to perforation of the large intestine and rectum and in postoperative complications after resection of the large intestine and rectum].

Journal: Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20021201

Title: Antimicrobial prophylaxis for transrectal prostatic biopsy: a prospective study of ciprofloxacin vs piperacillin/tazobactam.

Journal: BJU international 20021101

Title: Influence of a new prophylactic antibiotic therapy on the incidence of liver abscesses after chemoembolization treatment of liver tumors.

Journal: Journal of vascular and interventional radiology : JVIR 20021101

Title: Piperacillin/Tazobactam inducing seizures in a hemodialysed patient.

Journal: Clinical nephrology 20021001

Title: General microbiology and in vitro susceptibility of anaerobes isolated from complicated skin and skin-structure infections in patients enrolled in a comparative trial of ertapenem versus piperacillin-tazobactam.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020901

Title: Cefepime, piperacillin/tazobactam, gentamicin, ciprofloxacin, and levofloxacin alone and in combination against Pseudomonas aeruginosa.

Journal: Diagnostic microbiology and infectious disease 20020901

Title: Pharmacodynamic profiling of continuously infused piperacillin/tazobactam against Pseudomonas aeruginosa using Monte Carlo analysis.

Journal: Diagnostic microbiology and infectious disease 20020901

Title: Morganella morganii causing solitary liver abscess complicated by pyopericardium and left pleural effusion in a nondiabetic patient.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20020901

Title: Efficacy and tolerability of prophylactic treatment with intravenous piperacillin/tazobactam in patients undergoing hematopoietic stem cell transplantation.

Journal: Transplant infectious disease : an official journal of the Transplantation Society 20020901

Title: Successful medical management of emphysematous pyelonephritis.

Journal: The American journal of medicine 20020815

Title: New and rapid fully automated method for determination of tazobactam and piperacillin in fatty tissue and serum by column-switching liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020805

Title: Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of piperacillin and tazobactam in tazocin injectable powder.

Journal: Journal of pharmaceutical and biomedical analysis 20020731

Title: Cefepime plus amikacin versus piperacillin-tazobactam plus amikacin for initial antibiotic therapy in haematology patients with febrile neutropenia: results of an open, randomized, multicentre trial.

Journal: The Journal of antimicrobial chemotherapy 20020701

Title: Infecting one animal with two different strains of the same bacteria may cause misleading results.

Journal: Chemotherapy 20020701

Title: Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam when administered by continuous infusion and intermittent dosing.

Journal: Clinical therapeutics 20020701

Title: Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020601

Title: Emerging antimicrobial resistances among Proteus mirabilis in Europe: report from the MYSTIC Program (1997-2001). Meropenem Yearly Susceptibility Test Information Collection.

Journal: Journal of chemotherapy (Florence, Italy) 20020601

Title: Pharmacokinetic and pharmacodynamic evaluation of two dosing regimens for piperacillin-tazobactam.

Journal: Pharmacotherapy 20020501

Title: [A multicenter clinical trial of piperacillin/tazobactam in burn infection].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20020401

Title: [Candida parapsilosis endocarditis after prolonged antibiotic therapy].

Journal: Revista espanola de anestesiologia y reanimacion 20020401

Title: [Piperacillin-tazobactam in the treatment of severe nosocomial infections].

Journal: Recenti progressi in medicina 20020301

Title: Piperacillin 2 g/tazobactam 0.5 g is as effective as imipenem 0.5 g/cilastatin 0.5 g for the treatment of acute uncomplicated pyelonephritis and complicated urinary tract infections.

Journal: International journal of antimicrobial agents 20020201

Title: [In vitro interaction of tazobactam/piperacillin combined with aminoglycosides against Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli AND Staphylococcus aureus].

Journal: The Japanese journal of antibiotics 20020201

Title: [Study on water of crystallization in tazobactam].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020201

Title: Elimination of the piperacillin/tazobactam combination during continuous venovenous haemofiltration and haemodiafiltration in patients with acute renal failure.

Journal: The Journal of antimicrobial chemotherapy 20011201

Title: Treatment of pulmonary nocardiosis in heart-transplant patients: importance of susceptibility studies.

Journal: Clinical transplantation 20011201

Title: Molecular epidemiology of antibiotic-resistant gram-negative bacilli in a neonatal intensive care unit during a nonoutbreak period.

Journal: Pediatrics 20011101

Title: Evaluating possible pharmacokinetic interactions between tobramycin, piperacillin, and a combination of piperacillin and tazobactam in patients with various degrees of renal impairment.

Journal: Journal of clinical pharmacology 20010901

Title: Piperacillin/Tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010901

Title: An observational study on the epidemiology of respiratory tract bacterial pathogens and their susceptibility to four injectable beta-lactam antibiotics: piperacillin, piperacillin/tazobactam, ceftazidime and ceftriaxone.

Journal: Journal of chemotherapy (Florence, Italy) 20010801

Title: Faecal concentrations of piperacillin and tazobactam in elderly patients.

Journal: The Journal of antimicrobial chemotherapy 20010701

Title: Piperacillin, beta-lactam inhibitor plus gentamicin as empirical therapy of a sequential regimen in febrile neutropenia of pediatric cancer patients.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20010701

Title: A randomized prospective multicentre trial of cefpirome versus piperacillin-tazobactam in febrile neutropenia.

Journal: Leukemia & lymphoma 20010701

Title: Penicillins and beta-lactamase inhibitor combinations.

Journal: Journal of the American Veterinary Medical Association 20010615

Title: Inactivation of CMY-2 beta-lactamase by tazobactam: initial mass spectroscopic characterization.

Journal: Biochimica et biophysica acta 20010611

Title: Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20010423

Title: [Fundamental and clinical studies on beta-lactamase inhibitors].

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Journal: Nihon rinsho. Japanese journal of clinical medicine 20010401

Title: Systemic antibiotics fail to clear multidrug-resistant Klebsiella from a pediatric ICU.

Journal: Chest 20010301

Title: Treatment of nosocomial postoperative pneumonia in cancer patients: a prospective randomized study.

Journal: Annals of surgical oncology 20010301

Title: Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam.

Journal: Biochemistry 20010213

Title: Properties of multidrug-resistant, ESBL-producing Proteus mirabilis isolates and possible role of beta-lactam/beta-lactamase inhibitor combinations.

Journal: International journal of antimicrobial agents 20010201

Title: The role of topical antibiotic prophylaxis in patients undergoing contaminated head and neck surgery with flap reconstruction.

Journal: The Laryngoscope 20010201

Title: Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome.

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Title: [Multicentre clinical trial on efficacy and safety of domestic piperacillin/tazobactam for treatment of acute bacterial infections].

Journal: Zhonghua yi xue za zhi 20010110

Title: Possible role of cellular immunity: a case of cellulitis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010101

Title: Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model.

Journal: Chemotherapy 20010101

Title: Conjugative resistance to tazobactam plus piperacillin among extended-spectrum beta-lactamase-producing nosocomial Klebsiella pneumoniae.

Journal: Scandinavian journal of infectious diseases 20010101

Title: [Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas aeruginosa rods].

Journal: Medycyna doswiadczalna i mikrobiologia 20010101

Title: CAPD-associated peritonitis caused by Alcaligenes xylosoxidans sp. xylosoxidans.

Journal: American journal of nephrology 20010101

Title: Reversible bone marrow depression by high-dose piperacillin/tazobactam.

Journal: British journal of haematology 19961201

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