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91037-65-9,MFCD00076452
Catalog No.:AA00GRXS

91037-65-9 | Arg-gly-asp-ser

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1mg
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$6.00   $4.00
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10mg
98%
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50mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GRXS
Chemical Name:
Arg-gly-asp-ser
CAS Number:
91037-65-9
Molecular Formula:
C15H27N7O8
Molecular Weight:
433.4170
MDL Number:
MFCD00076452
SMILES:
OC[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)N
Properties
Computed Properties
 
Complexity:
665  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
14  
XLogP3:
-7.3  

Downstream Synthesis Route

[1]Zhao,Ming;Peng,Shiqi[AdvancedSynthesisandCatalysis,1999,vol.341,#7,p.668-676]

[2]Lin;Zhao,Ming;Wang,Chao;Peng,Shiqi[Bioorganicandmedicinalchemistryletters,2002,vol.12,#4,p.585-587]Bi,Wei;Bi,Lanrong;Cai,Jianhui;Liu,Sanguang;Peng,Shiqi;Fischer,NicholasO.;Tok,JeffreyB.-H.;Wang,Guohua[BioorganicandMedicinalChemistryLetters,2006,vol.16,#17,p.4523-4527]

Arg(Nω-NO2)-Gly-Asp(OBn)-Ser(Bn)-OBnhydrochloride 
  91037-65-9 

[1]Xiong,Yu;Zhao,Ming;Wang,Chao;Heng,WeiChang;Peng,Shiqi[JournalofMedicinalChemistry,2007,vol.50,#14,p.3340-3353]

H-Gly-Asp(OBzl)-Ser(Bzl)-OBzl*HCl 
  91037-65-9 

[1]Xiong,Yu;Zhao,Ming;Wang,Chao;Heng,WeiChang;Peng,Shiqi[JournalofMedicinalChemistry,2007,vol.50,#14,p.3340-3353]

H-Asp(Bzl)-Ser(Bzl)-OBzlhydrochloride 
  91037-65-9 

[1]Xiong,Yu;Zhao,Ming;Wang,Chao;Heng,WeiChang;Peng,Shiqi[JournalofMedicinalChemistry,2007,vol.50,#14,p.3340-3353]

[1]Yu,Hualong;Mei,Shenghui;Zhao,Li;Zhao,Ming;Wang,Yuji;Zhu,Haimei;Wang,Yaonan;Wu,Jianhui;Cui,Chunying;Xu,Wenyun;Peng,Shiqi[MedChemComm,2015,vol.6,#7,p.1345-1351]

[2]Xiong,Yu;Zhao,Ming;Wang,Chao;Heng,WeiChang;Peng,Shiqi[JournalofMedicinalChemistry,2007,vol.50,#14,p.3340-3353]

Literature

Title: Self-assembly of a dual functional bioactive peptide amphiphile incorporating both matrix metalloprotease substrate and cell adhesion motifs.

Journal: Soft matter 20150428

Title: Mosaic hydrogels: one-step formation of multiscale soft materials.

Journal: Advanced materials (Deerfield Beach, Fla.) 20120717

Title: Synthetic RGDS peptide attenuates mechanical ventilation-induced lung injury in rats.

Journal: Experimental lung research 20120501

Title: Dense surface functionalization using peptides that recognize differences in organized structures of self-assembling nanomaterials.

Journal: Molecular bioSystems 20120401

Title: Engineering membrane scaffolds with both physical and biomolecular signaling.

Journal: Acta biomaterialia 20120301

Title: RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells.

Journal: International journal of nanomedicine 20120101

Title: Covalently grafted VEGF(165) in hydrogel models upregulates the cellular pathways associated with angiogenesis.

Journal: American journal of physiology. Cell physiology 20111101

Title: Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway.

Journal: Journal of cellular biochemistry 20111001

Title: RGD mimetics containing phthalimidine fragment as novel ligands of fibrinogen receptor.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: Photosensitive chitosan to control cell attachment.

Journal: Journal of colloid and interface science 20110901

Title: Development of bioactive photocrosslinkable fibrous hydrogels.

Journal: Journal of biomedical materials research. Part A 20110801

Title: The integrin-binding motif RGDS induces protein tyrosine phosphorylation without activation in Bufo arenarum (Amphibia) oocytes.

Journal: Reproduction (Cambridge, England) 20110501

Title: Modulus-driven differentiation of marrow stromal cells in 3D scaffolds that is independent of myosin-based cytoskeletal tension.

Journal: Biomaterials 20110301

Title: Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.

Journal: Integrative biology : quantitative biosciences from nano to macro 20110301

Title: A new Ser472Asn (Cab2(a+)) polymorphism localized within the αIIb 'thigh' domain is involved in neonatal thrombocytopenia.

Journal: Transfusion 20110201

Title: Biomimetic hydrogels with VEGF induce angiogenic processes in both hUVEC and hMEC.

Journal: Biomacromolecules 20110110

Title: Micron-scale spatially patterned, covalently immobilized vascular endothelial growth factor on hydrogels accelerates endothelial tubulogenesis and increases cellular angiogenic responses.

Journal: Tissue engineering. Part A 20110101

Title: RAM, an RGDS analog, exerts potent anti-melanoma effects in vitro and in vivo.

Journal: PloS one 20110101

Title: RGDS-fuctionalized alginates improve the survival rate of encapsulated embryonic stem cells during cryopreservation.

Journal: Cryo letters 20110101

Title: Biological synthesis of tooth enamel instructed by an artificial matrix.

Journal: Biomaterials 20101201

Title: Degree of immobilization of synthetic RGDS(PO(3)H(2))PA peptides on titanium surfaces.

Journal: Dental materials journal 20101101

Title: Effects of RGDS sequence genetically interfused in the silk fibroin light chain protein on chondrocyte adhesion and cartilage synthesis.

Journal: Biomaterials 20101001

Title: Three-dimensional photopatterning of hydrogels using stereolithography for long-term cell encapsulation.

Journal: Lab on a chip 20100821

Title: Derivatives of tetrahydroisoquinoline: synthesis and initial evaluation of novel non-peptide antagonists of the alpha(IIb)beta(3)-integrin.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Adjuvant engineering for cancer immunotherapy: Development of a synthetic TLR2 ligand with increased cell adhesion.

Journal: Cancer science 20100701

Title: Spreading by snail (Lymnaea stagnalis) defence cells is regulated through integrated PKC, FAK and Src signalling.

Journal: Cell and tissue research 20100701

Title: Hydrogel cell patterning incorporating photocaged RGDS peptides.

Journal: Biomedical microdevices 20100601

Title: Surface functionalization of polycaprolactone films via surface-initiated atom transfer radical polymerization for covalently coupling cell-adhesive biomolecules.

Journal: Biomaterials 20100401

Title: [Evaluating thrombolytic efficacy and thrombus targetability of RGDS-liposomes encapsulating subtilisin FS33 in vivo].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20100401

Title: The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma.

Journal: American journal of respiratory and critical care medicine 20100315

Title: Development of bioactive peptide amphiphiles for therapeutic cell delivery.

Journal: Acta biomaterialia 20100101

Title: Intracellular targets of RGDS peptide in melanoma cells.

Journal: Molecular cancer 20100101

Title: Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation.

Journal: Cell adhesion & migration 20100101

Title: Effect of RGDS-expressing fibroin dose on initial adhesive force of a single chondrocyte.

Journal: Bio-medical materials and engineering 20100101

Title: Experimental study of the preparation of targeted microbubble contrast agents carrying urokinase and RGDS.

Journal: Ultrasonics 20091201

Title: Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype.

Journal: American journal of respiratory cell and molecular biology 20091001

Title: Binding of plasma factor XIII to thrombin-receptor activated human platelets.

Journal: Thrombosis and haemostasis 20090701

Title: Controlled capture and release of cardiac fibroblasts using peptide-functionalized alginate gels in microfluidic channels.

Journal: Lab on a chip 20090607

Title: The role of RGD-tagged helical rosette nanotubes in the induction of inflammation and apoptosis in human lung adenocarcinoma cells through the P38 MAPK pathway.

Journal: Biomaterials 20090601

Title: Photodegradable hydrogels for dynamic tuning of physical and chemical properties.

Journal: Science (New York, N.Y.) 20090403

Title: Inhibition of integrin alphavbeta3 prevents urokinase plasminogen activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.

Journal: American journal of physiology. Heart and circulatory physiology 20090301

Title: Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress.

Journal: Blood 20090212

Title: Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways.

Journal: Respiratory research 20090101

Title: Development of a RGDS-peptide modified polyurethane for tissue regeneration.

Journal: Advances in experimental medicine and biology 20090101

Title: A simple electrochemical cytosensor array for dynamic analysis of carcinoma cell surface glycans.

Journal: Angewandte Chemie (International ed. in English) 20090101

Title: Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels.

Journal: Journal of biomaterials science. Polymer edition 20090101

Title: Titanium foam-bioactive nanofiber hybrids for bone regeneration.

Journal: Journal of tissue engineering and regenerative medicine 20081201

Title: Cellular procoagulant activity dictates clot structure and stability as a function of distance from the cell surface.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20081201

Title: Alcalase-catalysed synthesis of the precursor tetrapeptide N-benzoylarginylglycylaspartylserinamide (Bz-RGDS-NH2) of the cell-adhesion peptide arginylglycylaspartylserine (RGDS).

Journal: Biotechnology and applied biochemistry 20081101

Title: Influence of integrin-blocking peptide on gadolinium- and hypertonic shrinking-induced neurotransmitter release in rat brain synaptosomes.

Journal: Neurochemical research 20080701

Title: Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.

Journal: Biomaterials 20080701

Title: Peptide array-based screening of human mesenchymal stem cell-adhesive peptides derived from fibronectin type III domain.

Journal: Biochemical and biophysical research communications 20080620

Title: Expression of podocalyxin enhances the adherence, migration, and intercellular communication of cells.

Journal: Experimental cell research 20080610

Title: Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation.

Journal: Platelets 20080501

Title: A class of novel nitronyl nitroxide labeling basic and acidic amino acids: synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigations.

Journal: Bioorganic & medicinal chemistry 20080401

Title: Covalent functionalization of NiTi surfaces with bioactive peptide amphiphile nanofibers.

Journal: Biomaterials 20080301

Title: Physico-chemical and thermodynamic aspects of fibroblastic attachment on RGDS-modified chitosan membranes.

Journal: Colloids and surfaces. B, Biointerfaces 20080215

Title: TGF beta-induced contraction is not promoted by fibronectin-fibronectin receptor interaction, or alpha SMA expression.

Journal: Investigative ophthalmology & visual science 20080201

Title: A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity.

Journal: Cancer research 20080101

Title: Adhesion to fibronectin induces megakaryocytic differentiation of JAS-REN cells.

Journal: Anticancer research 20080101

Title: RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis.

Journal: Journal of biomedical materials research. Part A 20071201

Title: EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.

Journal: Cellular signalling 20071201

Title: The use of biotin-avidin binding to facilitate biomodification of thermoresponsive culture surfaces.

Journal: Biomaterials 20071201

Title: Src tyrosine kinases mediate activations of NF-kappaB and integrin signal during lipopolysaccharide-induced acute lung injury.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20071115

Title: Patterned biofunctional designs of thermoresponsive surfaces for spatiotemporally controlled cell adhesion, growth, and thermally induced detachment.

Journal: Biomaterials 20070901

Title: [The degrading mechanism of collagen promoted by RGDS in hepatic stellate cell].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070901

Title: Improved anti-osteoporosis potency and reduced endometrial membrane hyperplasia during hormone replacement therapy with estrogen-RGD peptide conjugates.

Journal: Journal of medicinal chemistry 20070712

Title: Glucose modulates handling of apoptotic cells by mesangial cells: involvement of TGF-beta1.

Journal: Laboratory investigation; a journal of technical methods and pathology 20070701

Title: Evaluation of L929 fibroblast attachment and proliferation on Arg-Gly-Asp-Ser (RGDS)-immobilized chitosan in serum-containing/serum-free cultures.

Journal: Journal of bioscience and bioengineering 20070701

Title: Chondrogenic differentiation potential of human mesenchymal stem cells photoencapsulated within poly(ethylene glycol)-arginine-glycine-aspartic acid-serine thiol-methacrylate mixed-mode networks.

Journal: Tissue engineering 20070501

Title: Efficient modification on PLLA by ozone treatment for biomedical applications.

Journal: Macromolecular bioscience 20070410

Title: Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis.

Journal: Journal of leukocyte biology 20070301

Title: The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation.

Journal: Biomaterials 20070101

Title: Bio-functionalized thermoresponsive interfaces facilitating cell adhesion and proliferation.

Journal: Biomaterials 20061001

Title: Staphylococcus aureus adhesion via Spa, ClfA, and SdrCDE to immobilized platelets demonstrates shear-dependent behavior.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20061001

Title: Synthesis of tetrapeptide Bz-RGDS-NH2 by a combination of chemical and enzymatic methods.

Journal: Journal of biotechnology 20060918

Title: Dual-acting agents that possess free radical scavenging and antithrombotic activities: design, synthesis, and evaluation of phenolic tetrahydro-beta-carboline RGD peptide conjugates.

Journal: Bioorganic & medicinal chemistry letters 20060901

Title: [Inhibitory effect of RGDS peptide on experimental choroidal neovascularization in a rat model].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20060901

Title: Integrin engagement modulates the phosphorylation of focal adhesion kinase, phagocytosis, and cell spreading in molluscan defence cells.

Journal: Biochimica et biophysica acta 20060801

Title: Biomimetic modification of titanium dental implant model surfaces using the RGDSP-peptide sequence: a cell morphology study.

Journal: Biomaterials 20060701

Title: Effects of CD44 antibody-- or RGDS peptide--immobilized magnetic beads on cell proliferation and chondrogenesis of mesenchymal stem cells.

Journal: Journal of biomedical materials research. Part A 20060615

Title: Presentation of RGDS epitopes on self-assembled nanofibers of branched peptide amphiphiles.

Journal: Biomacromolecules 20060601

Title: Synthesis of a precursor dipeptide of RGDS (Arg-Gly-Asp-Ser) catalysed by the industrial protease alcalase.

Journal: Biotechnology and applied biochemistry 20060501

Title: Photolithographic patterning of polyethylene glycol hydrogels.

Journal: Biomaterials 20060401

Title: RGD-containing molecules induce macropinocytosis in ascidian hyaline amoebocytes.

Journal: Journal of invertebrate pathology 20060201

Title: Promotion of cell affinity of porous PLLA scaffolds by immobilization of RGD peptides via plasma treatment.

Journal: Macromolecular bioscience 20060105

Title: Inhibition of nitric oxide and caspase-3 mediated apoptosis by a tetrapeptide derivative (PEP1261) in cultured synovial fibroblasts from collagen-induced arthritis.

Journal: Molecular and cellular biochemistry 20060101

Title: CHO cells expressing the high affinity alpha(IIb)beta3 T562N integrin demonstrate enhanced adhesion under shear.

Journal: Journal of thrombosis and haemostasis : JTH 20060101

Title: Generic bioaffinity silicone surfaces.

Journal: Bioconjugate chemistry 20060101

Title: Alcalase-catalyzed, kinetically controlled synthesis of a precursor dipeptide of RGDS in organic solvents.

Journal: Preparative biochemistry & biotechnology 20060101

Title: Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20051205

Title: Effects of glycoprotein IIb/IIIa antagonists and chloride channel blockers on platelet cytoplasmic free calcium.

Journal: Chinese medical journal 20051205

Title: Comparison of sea turtle thrombocyte aggregation to human platelet aggregation in whole blood.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20051101

Title: Characterization of labeled neural progenitor cells for magnetic targeting.

Journal: Neuroreport 20051017

Title: Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion.

Journal: Biomaterials 20050801

Title: [Targeted adhesion of platelet receptor-specific microbubble agent to thrombus in vitro].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050601

Title: P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets.

Journal: Thrombosis and haemostasis 20050501

Title: alpha-Adrenergic-mediated activation of human reconstituted fibrinogen receptor (integrin alphaIIbbeta3) in Chinese hamster ovary cells.

Journal: Thrombosis and haemostasis 20041201

Title: A novel RGDS-analog inhibits angiogenesis in vitro and in vivo.

Journal: Biochemical and biophysical research communications 20040903

Title: Formation of focal adhesions on fibronectin promotes fluid shear stress induction of COX-2 and PGE2 release in MC3T3-E1 osteoblasts.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20040701

Title: Biomimetic approach on human periodontal ligament cells using synthetic oligopeptides.

Journal: Journal of periodontology 20040701

Title: RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.

Journal: Blood 20040601

Title: Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes.

Journal: Investigative ophthalmology & visual science 20040601

Title: Conformationally tailored N-[(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)carbonyl]proline templates as molecular tools for the design of peptidomimetics. Design and synthesis of fibrinogen receptor antagonists.

Journal: Organic & biomolecular chemistry 20040521

Title: Gadolinium effects on gigaseal formation and the adhesive properties of a fungal amoeboid cell, the slime mutant of Neurospora crassa.

Journal: The Journal of membrane biology 20040315

Title: Immobilization of cell-adhesive peptides to temperature-responsive surfaces facilitates both serum-free cell adhesion and noninvasive cell harvest.

Journal: Tissue engineering 20040101

Title: Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides.

Journal: Bioorganic & medicinal chemistry letters 20031117

Title: Silent cleanup of very early apoptotic cells by macrophages.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20031101

Title: Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells.

Journal: Cell death and differentiation 20031001

Title: Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation and modulation by interferon-beta.

Journal: Glia 20030901

Title: Arg-Gly-Asp-Ser (RGDS) peptide stimulates transforming growth factor beta1 transcription and secretion through integrin activation.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801

Title: [Effects of Arg-Gly-Asp-Ser tetrapeptide on integrin signaling and apoptosis in hepatic stellate cells].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20030801

Title: Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation.

Journal: The Journal of biological chemistry 20030718

Title: Optimized conventional synthesis of 'RGD' and 'RGDS' peptides and their sarcosine mimics as integrin GP IIb/IIIa antagonists.

Journal: Amino acids 20030601

Title: Nonpeptide RGD antagonists: a novel class of mimetics, the 5,8-disubstituted 1-azabicyclo[5.2.0]nonan-2-one lactam.

Journal: Bioorganic & medicinal chemistry letters 20030505

Title: Adhesion and migration of marrow-derived osteoblasts on injectable in situ crosslinkable poly(propylene fumarate-co-ethylene glycol)-based hydrogels with a covalently linked RGDS peptide.

Journal: Journal of biomedical materials research. Part A 20030501

Title: Integrin antagonists affect growth and pathfinding of ventral motor nerves in the trunk of embryonic zebrafish.

Journal: Molecular and cellular neurosciences 20030501

Title: Connection between integrins and cell activation in rat adrenal glomerulosa cells: a role for Arg-Gly-Asp peptide in the activation of the p42/p44(mapk) pathway and intracellular calcium.

Journal: Endocrinology 20030401

Title: House dust mite Dermatophagoides farinae augments proinflammatory mediator productions and accessory function of alveolar macrophages: implications for allergic sensitization and inflammation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030101

Title: Mechanisms by which extracellular matrix components induce osteoblast apoptosis.

Journal: Connective tissue research 20030101

Title: Micropatterned surfaces modified with select peptides promote exclusive interactions with osteoblasts.

Journal: Biomaterials 20021001

Title: Molecular mechanism involved in matrix dependent upregulation of matrix metalloproteinases in monocyte/macrophage.

Journal: Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) 20021001

Title: Large-scale purification of active platelet integrin glycoprotein IIb-IIIa.

Journal: Protein expression and purification 20020801

Title: Phagocyte spreading and phagocytosis in the compound ascidian Botryllus schlosseri: evidence for an integrin-like, RGD-dependent recognition mechanism.

Journal: Developmental and comparative immunology 20020501

Title: Cell migration through defined, synthetic ECM analogs.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020501

Title: Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement.

Journal: The Biochemical journal 20020501

Title: Pharmacological properties of YM-57029, a novel platelet glycoprotein IIb/IIIa antagonist.

Journal: European journal of pharmacology 20020329

Title: Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence.

Journal: Bioorganic & medicinal chemistry letters 20020225

Title: Non-antisense cellular responses to oligonucleotides.

Journal: FEBS letters 20020116

Title: Matrix regulation of skeletal cell apoptosis II: role of Arg-Gly-Asp-containing peptides.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020101

Title: The central role of thromboxane and platelet activating factor receptors in ex vivo regulation of endotoxin-induced monocyte tissue factor activity in human whole blood.

Journal: Journal of endotoxin research 20020101

Title: Glow discharge plasma treatment of titanium plates enhances adhesion of osteoblast-like cells to the plates through the integrin-mediated mechanism.

Journal: The International journal of oral & maxillofacial implants 20020101

Title: Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo.

Journal: Biochimica et biophysica acta 20011219

Title: Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets.

Journal: FEBS letters 20011102

Title: An RGDS peptide-binding receptor, FR-1R, localizes to the basal side of the ectoderm and to primary mesenchyme cells in sand dollar embryos.

Journal: Development, growth & differentiation 20011001

Title: Induction of apoptosis of integrin-expressing human prostate cancer cells by cyclic Arg-Gly-Asp peptides.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

Title: Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3.

Journal: Journal of medicinal chemistry 20010913

Title: Activation of caspase-3/caspase-3-like activity in rat cardiomyocytes by an RGD peptide, but not the GPIIb/IIIa antagonist lotrafiban.

Journal: Thrombosis research 20010715

Title: Mechanisms of enhanced osteoblast adhesion on nanophase alumina involve vitronectin.

Journal: Tissue engineering 20010601

Title: Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold.

Journal: Journal of medicinal chemistry 20010412

Title: Integrin-like RGD-dependent cell adhesion mechanism is involved in the rapid killing of Onchocerca microfilariae during early infection of Simulium damnosum s.l.

Journal: Parasitology 20010401

Title: Greater inhibition of platelet procoagulant activity by antibody-derived glycoprotein IIb--IIIa inhibitors than by peptide and peptidomimetic inhibitors.

Journal: British journal of haematology 20010401

Title: Evidence from site-directed mutagenesis that the cytoplasmic domain of the beta3 subunit influences the conformational state of the alphaVbeta3 integrin ectodomain.

Journal: Thrombosis and haemostasis 20010401

Title: Filopodial calcium transients promote substrate-dependent growth cone turning.

Journal: Science (New York, N.Y.) 20010309

Title: Heterobifunctional ligands: practical chemoenzymatic synthesis of a cell adhesive glycopeptide that interacts with both selectins and integrins.

Journal: Journal of medicinal chemistry 20010301

Title: In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist.

Journal: European journal of pharmacology 19991119

Title: Histological distribution of FR-1, a cyclic RGDS-peptide, binding sites during early embryogenesis, and isolation and initial characterization of FR-1 receptor in the sand dollar embryo.

Journal: Development, growth & differentiation 19970401

Title: Arg-Gly-Asp-Ser-selective adhesion and the stabilization of long-term potentiation: pharmacological studies and the characterization of a candidate matrix receptor.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19970215

Title: Differential effects of fibronectin-derived oligopeptides on the attachment of rabbit lens epithelial cells in vitro.

Journal: Ophthalmic research 19960101

Title: Binding site in human plasma fibronectin to HL-60 cells localizes in the C-terminal heparin-binding region independently of RGD and CS1.

Journal: Experimental cell research 19950401

Title: Arg-Gly-Asp-Ser peptide analogs suppress cartilage chondrolytic activities of integrin-binding and nonbinding fibronectin fragments.

Journal: Archives of biochemistry and biophysics 19940401

Title: Fibroblast attachment to Arg-Gly-Asp peptide-immobilized poly(gamma-methyl L-glutamate).

Journal: Journal of biomaterials science. Polymer edition 19940101

Title: Adhesive interaction of hemopoietic progenitor cell membrane with the RGD domain of fibronectin.

Journal: Biochimica et biophysica acta 19930919

Title: Mouse antithrombotic assay. Inhibition of platelet thromboembolism by disintegrins.

Journal: Thrombosis research 19930815

Title: Cell-attachment activities of surface immobilized oligopeptides RGD, RGDS, RGDV, RGDT, and YIGSR toward five cell lines.

Journal: Journal of biomaterials science. Polymer edition 19930101

Title: Diphosphorylation of platelet myosin ex vivo in the initial phase of activation by thrombin.

Journal: Biochimica et biophysica acta 19920722

Title: Angiogenin supports endothelial and fibroblast cell adhesion.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19920315

Title: Ca2+-dependent binding of a synthetic Arg-Gly-Asp (RGD) peptide to a single site on the purified platelet glycoprotein IIb-IIIa complex.

Journal: The Journal of biological chemistry 19890805

Title: Fibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulation.

Journal: The Journal of clinical investigation 19880501

Title: The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

Journal: The Journal of biological chemistry 19851005

Title: Grigoriou V, et al. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem. 2005 Jan 21;280(3):1733-9.

Title: Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18.

Title: Yin X, et al. Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice. J Gastroenterol Hepatol. 2014 Jun;29(6):1308-15.

Title: Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.

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Tags:91037-65-9 Molecular Formula|91037-65-9 MDL|91037-65-9 SMILES|91037-65-9 Arg-gly-asp-ser