Title: The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models.
Journal: Molecular cancer therapeutics 20120801
Title: Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors.
Journal: Neoplasia (New York, N.Y.) 20120801
Title: Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program.
Journal: Pediatric blood & cancer 20120715
Title: The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer.
Journal: Cancer science 20120301
Title: Advancing fragment binders to lead-like compounds using ligand and protein-based NMR spectroscopy.
Journal: Methods in enzymology 20110101
Title: Structural determination of three different series of compounds as Hsp90 inhibitors using 3D-QSAR modeling, molecular docking and molecular dynamics methods.
Journal: International journal of molecular sciences 20110101
Title: Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Journal: Journal of medicinal chemistry 20100826
Title: Woodhead AJ, et al. Discovery of (2,4-dihydroxy-5-isopropylphenyl)--(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-ylmethanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. J Med Chem. 2010 Aug 26;53(16):5956-69.
Title: Kang MH, et al. Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Jul 15;59(1):185-8.
