Home Other Building Blocks 93-07-2
93-07-2,MFCD00002500
Catalog No.:AA0033FX

93-07-2 | 3,4-Dimethoxybenzoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25g
98%
in stock  
$7.00   $5.00
- +
100g
98%
in stock  
$21.00   $15.00
- +
500g
98%
in stock  
$97.00   $68.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0033FX
Chemical Name:
3,4-Dimethoxybenzoic acid
CAS Number:
93-07-2
Molecular Formula:
C9H10O4
Molecular Weight:
182.1733
MDL Number:
MFCD00002500
SMILES:
COc1cc(ccc1OC)C(=O)O
NSC Number:
7721
Properties
Properties
 
BP:
302.938 °C at 760 mmHg  
Form:
Solid  
MP:
179-182 °C(lit.)  
Refractive Index:
1.4500 (estimate)  
Solubility:
0.5g/l  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
181  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.6  

Upstream Synthesis Route

[1]HelveticaChimicaActa,2012,vol.95,#4,p.586-593

[1]ActaChimicaAcademiaeScientiarumHungaricae,1980,vol.103,#2,p.259-270

[1]TetrahedronLetters,2016,vol.57,#34,p.3841-3843

[1]SyntheticCommunications,2007,vol.37,#10,p.1665-1673

[2]JournalofChemicalResearch-PartS,1998,#3,p.136-137

[3]JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999),1982,#10,p.2477-2486

[4]JournaloftheAmericanChemicalSociety,1948,vol.70,p.60,62

[1]JournalofMedicinalChemistry,2001,vol.44,#23,p.3978-3984

Downstream Synthesis Route

[1]ChemMedChem,2020

[2]MonatsheftefurChemie,2004,vol.135,p.83-87

[3]SyntheticCommunications,2009,vol.39,p.3459-3470

[4]Patent:WO2015/161830,2015,A1.Locationinpatent:Paragraph00289

[5]JustusLiebigsAnnalenderChemie,1871,vol.159,p.243

[6]EuropeanJournalofMedicinalChemistry,2017,vol.130,p.73-85

[7]AdvancedSynthesisandCatalysis,2018,vol.360,p.2204-2210

[1]ChemischeBerichte,1895,vol.28,p.810

[1]Lettersindrugdesignanddiscovery,2012,vol.9,p.276-281

[2]Synlett,2015,vol.26,p.2006-2008

[3]BioorganicandMedicinalChemistryLetters,2001,vol.11,p.1493-1496

[4]Tetrahedron,2003,vol.59,p.7231-7243

[5]Patent:CN105037279,2017,B.Locationinpatent:Paragraph0043;0044

[6]Molecules,2019,vol.24

[7]EuropeanJournalofMedicinalChemistry,2009,vol.44,p.689-700

[8]ChemischeBerichte,1878,vol.11,p.133

[9]ChemischeBerichte,1941,vol.74,p.1002

[10]ArchivderPharmazie,1933,vol.271,p.292,295

[11]JournalofAgriculturalandFoodChemistry,2003,vol.51,p.6953-6956

[12]BioorganicandMedicinalChemistryLetters,2008,vol.18,p.1297-1303

[13]ACSMedicinalChemistryLetters,2010,vol.1,p.145-149

[14]BioorganicandMedicinalChemistry,2009,vol.17,p.6279-6285

[15]JournalofAgriculturalandFoodChemistry,2012,vol.60,p.1036-1041

[16]BulletinoftheKoreanChemicalSociety,2012,vol.33,p.2741-2747

[17]AustralianJournalofChemistry,2012,vol.65,p.1413-1419,7

[18]MedicinalChemistryResearch,2014,vol.23,p.1661-1671

[19]BioorganicChemistry,2016,vol.69,p.48-63

[20]Lettersindrugdesignanddiscovery,2016,vol.13,p.968-981

[21]PharmaceuticalChemistryJournal,2018,vol.51,p.907-917

[22]Patent:WO2020/16389,2020,A1.Locationinpatent:Paragraph0154

[1]JustusLiebigsAnnalenderChemie,1858,vol.108,p.60

[1]Patent:US2018/86687,2018,A1.Locationinpatent:Paragraph0061;0062;0067;0068-0073

[2]JustusLiebigsAnnalenderChemie,1871,vol.159,p.243

[3]Tetrahedron,1984,vol.40,p.2731

[4]Patent:WO2007/103260,2007,A1.Locationinpatent:Page/Pagecolumn62

[5]Patent:US2013/253222,2013,A1.Locationinpatent:Paragraph0028;0029

[6]TetrahedronLetters,2015,vol.56,p.784-788

[7]TetrahedronLetters,2015,vol.56,p.941-945

[8]Patent:WO2020/16389,2020,A1

Literature

Title: Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: vidalol B.

Journal: European journal of medicinal chemistry 20120801

Title: Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet.

Journal: Molecular and cellular biochemistry 20120701

Title: Effect of veratric acid on the cardiovascular risk of L-NAME-induced hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20120601

Title: Simultaneous determination of sulpiride and mebeverine by HPLC method using fluorescence detection: application to real human plasma.

Journal: Chemistry Central journal 20120101

Title: Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats.

Journal: European journal of pharmacology 20111205

Title: 2-(4-Chloro-phen-yl)-2-oxoethyl 3,4-dimeth-oxy-benzoate.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.

Journal: Journal of agricultural and food chemistry 20110914

Title: Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials.

Journal: Molecules (Basel, Switzerland) 20110505

Title: Tunability of the M(II)M(III)/M(II)(2) and M(III)(2)/M(II)M(III) (M=Mn, Co) couples in bis-μ-O,O'-carboxylato-μ-OR bridged complexes.

Journal: Dalton transactions (Cambridge, England : 2003) 20110407

Title: Induction and transcriptional regulation of laccases in fungi.

Journal: Current genomics 20110401

Title: Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.

Journal: Bioorganic & medicinal chemistry 20110215

Title: Structure-activity relationships and the cytotoxic effects of novel diterpenoid alkaloid derivatives against A549 human lung carcinoma cells.

Journal: Journal of natural medicines 20110101

Title: Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion.

Journal: BMC complementary and alternative medicine 20110101

Title: Nonlinear changes in the activity of the oxygen-dependent demethylase system in Rhodococcus erythropolis cells in the presence of low and very low doses of formaldehyde.

Journal: Nonlinear biomedical physics 20110101

Title: Photoenhanced degradation of veratraldehyde upon the heterogeneous ozone reactions.

Journal: Physical chemistry chemical physics : PCCP 20100721

Title: Thermal analysis applied to verapamil hydrochloride characterization in pharmaceutical formulations.

Journal: Molecules (Basel, Switzerland) 20100408

Title: Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2.

Journal: Molecular bioSystems 20100101

Title: Biochemistry and occurrence of o-demethylation in plant metabolism.

Journal: Frontiers in physiology 20100101

Title: Bis(3,4-dimethoxy-benzoato-κO,O')(1,10-phenanthroline-κN,N')copper(II).

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: [Spectroscopic investigation on the interaction of protocatechuic acid and veratric acid with biomacromolecules].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20090601

Title: Influence of Honey on the Suppression of Human Low Density Lipoprotein (LDL) Peroxidation (In vitro).

Journal: Evidence-based complementary and alternative medicine : eCAM 20090301

Title: Hansch analysis of veratric acid derivatives as antimicrobial agents.

Journal: European journal of medicinal chemistry 20090201

Title: Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Journal: Journal of hematology & oncology 20090101

Title: Influence of very low doses of mediators on fungal laccase activity - nonlinearity beyond imagination.

Journal: Nonlinear biomedical physics 20090101

Title: Assessment of the genotoxicity of olive mill waste water (OMWW) with the Vicia faba micronucleus test.

Journal: Mutation research 20071201

Title: Synthesis of crispine A analogues via an intramolecular Schmidt reaction.

Journal: Beilstein journal of organic chemistry 20070101

Title: Molecular cloning of streptomyces genes encoding vanillate demethylase.

Journal: Bioscience, biotechnology, and biochemistry 20060901

Title: Isolation and characterization of Streptomyces sp. NL15-2K capable of degrading lignin-related aromatic compounds.

Journal: Journal of bioscience and bioengineering 20060801

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Investigative implications of the instability and metabolism of mebeverine.

Journal: Journal of analytical toxicology 20060301

Title: Thermally assisted hydrolysis and methylation of purified tannins from plants.

Journal: Analytical chemistry 20050901

Title: Trollioside, a new compound from the flowers of Trollius chinensis.

Journal: Journal of Asian natural products research 20040601

Title: Acylated flavone C-glycosides from Trollius ledebouri.

Journal: Journal of natural products 20040401

Title: Biotransformation of lignin polymers derived from beech wood pulping by Sporobolomyces roseus isolated from leafy material.

Journal: Biotechnology letters 20040301

Title: [Phenyl pyrazolones--novel oxidoreductase redox-mediators for degradation of xenobiotics].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20040101

Title: Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities.

Journal: Chemical & pharmaceutical bulletin 20031201

Title: Tyrosinase inhibitor from black rice bran.

Journal: Journal of agricultural and food chemistry 20031119

Title: Mechanistic features of lignin peroxidase-catalyzed oxidation of substituted phenols and 1,2-dimethoxyarenes.

Journal: The Journal of biological chemistry 20031010

Title: Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter.

Journal: Mycological research 20030801

Title: Lignin degradation in a compost environment by the deuteromycete Paecilomyces inflatus.

Journal: Applied microbiology and biotechnology 20030501

Title: Induction of laccase activity in the edible straw mushroom, Volvariella volvacea.

Journal: FEMS microbiology letters 20030121

Title: Relationship of demethylation processes to veratric acid concentration and cell density in cultures of Rhodococcus erythropolis.

Journal: Cell biology international 20030101

Title: [Studies on structural elucidation of Aconitum diterpenoid alkaloid by LC-APCI-MS and effects of Aconitum diterpenoid alkaloid on cutaneous blood flow].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021101

Title: [A study on chemical constituents in the herb of Mentha spicata].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20021001

Title: Identification of mebeverine acid as the main circulating metabolite of mebeverine in man.

Journal: Journal of pharmaceutical and biomedical analysis 20020620

Title: Influence of aromatic compounds on biodegradation of [14C]-labeled xylan and mannan by the white-rot fungus Phlebia radiata.

Journal: Journal of industrial microbiology & biotechnology 20020301

Title: Synthesis of aromatic nitrogen mustard agents and analysis of their alkylation activity at physiological pH and temperature.

Journal: Physiological chemistry and physics and medical NMR 20020101

Title: Kinetic model for phenolic compound oxidation by Fenton's reagent.

Journal: Chemosphere 20011001

Title: Comamonas testosteroni BR6020 possesses a single genetic locus for extradiol cleavage of protocatechuate.

Journal: Microbiology (Reading, England) 20010801

Title: Differential regulation of laccase gene expression in Pleurotus sajor-caju.

Journal: Microbiology (Reading, England) 20010701

Title: Isolation and characterization of a veratrol:corrinoid protein methyl transferase from Acetobacterium dehalogenans.

Journal: Archives of microbiology 20010501

Title: The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS.

Journal: Journal of analytical toxicology 20010101

Title: Fine structural specificity differences of trimethoprim allergenic determinants.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 19961001

Title: Choi WS, et al. Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. Int J Mol Med. 2015 Jan;35(1):202-10.

Title: Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94.

Title: Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:93-07-2 Molecular Formula|93-07-2 MDL|93-07-2 SMILES|93-07-2 3,4-Dimethoxybenzoic acid |Organic_Building_Blocks