Home Other Building Blocks 90-24-4
90-24-4,MFCD00017243
Catalog No.:AA003HBJ

90-24-4 | 2'-Hydroxy-4',6'-dimethoxyacetophenone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
95%
in stock  
$6.00   $4.00
- +
25mg
95%
in stock  
$9.00   $7.00
- +
50mg
95%
in stock  
$12.00   $8.00
- +
100mg
95%
in stock  
$15.00   $11.00
- +
250mg
95%
in stock  
$19.00   $14.00
- +
1g
95%
in stock  
$37.00   $26.00
- +
5g
95%
in stock  
$57.00   $40.00
- +
25g
95%
in stock  
$194.00   $136.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003HBJ
Chemical Name:
2'-Hydroxy-4',6'-dimethoxyacetophenone
CAS Number:
90-24-4
Molecular Formula:
C10H12O4
Molecular Weight:
196.1999
MDL Number:
MFCD00017243
SMILES:
COc1cc(OC)cc(c1C(=O)C)O
NSC Number:
17392
Properties
Properties
 
BP:
185°C/20mm  
Form:
Solid  
MP:
80-84 °C(lit.)  
Solubility:
Soluble in hot methanol.  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
204  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.7  

Upstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2018,vol.28,#11,p.2098-2102

[2]Patent:KR2018/64130,2018,A,

[1]Synthesis,1980,#11,p.874-875

[2]AustralianJournalofChemistry,2012,vol.65,#10,p.1377-1383,7

[3]JournalofChemicalResearch,2014,vol.38,#1,p.60-61

[4]Molecules,2014,vol.19,#7,p.8933-8948

[5]EuropeanJournalofMedicinalChemistry,2014,vol.86,p.153-164

[6]EuropeanJournalofMedicinalChemistry,2015,vol.97,p.259-274

[7]JournalofChemicalResearch,2015,vol.39,#9,p.550-552

[8]AsianJournalofChemistry,2016,vol.28,#5,p.1139-1143

[9]RSCAdvances,2016,vol.6,#69,p.64544-64556

[10]Synthesis(Germany),2018,vol.50,#8,p.1610-1620

[1]Synthesis,1982,#3,p.221-222

[1]TetrahedronLetters,2016,vol.57,#34,p.3841-3843

[1]JournalofHeterocyclicChemistry,2002,vol.39,#6,p.1251-1258

Downstream Synthesis Route

[1]Chen,Lijuan;Fan,Tiantian;Lei,Xiangui;Teichmann,AlexanderTobias;Wang,Amu;Wang,Chao;Wei,Zhe;Wieland,FrankHeinrich;Yang,Youzhe;Yin,Jinxiang;Zhou,Li;Zhu,Yue[EuropeanJournalofMedicinalChemistry,2020,vol.193]

[2]Narasimhachari;Seshadri[Proceedings-IndianAcademyofSciences,SectionA,1950,#32,p.17,21,22]

[1]Lin,An-Shen;Nakagawa-Goto,Kyoko;Chang,Fang-Rong;Yu,Donglei;Morris-Natschke,SusanL.;Wu,Chin-Chung;Chen,Shu-Li;Wu,Yang-Chang;Lee,Kuo-Hsiung[JournalofMedicinalChemistry,2007,vol.50,#16,p.3921-3927]

[2]Wei,Mingming;Xie,Maodun;Zhang,Zhen;Wei,Yujiao;Zhang,Juan;Pan,Hongli;Li,Benlong;Wang,Jingjing;Song,Yang;Chong,Chuangke;Zhao,Rui;Wang,Jiefu;Yu,Li;Yang,Guang;Yang,Cheng[EuropeanJournalofMedicinalChemistry,2020,vol.206]

[3]Mahal;Venkataraman[JournaloftheChemicalSociety,1936,p.569]

[4]Mizuno,Mizuo;Kojima,Hiroyuki;Tanaka,Toshijuki;Iinuma,Munekazu;Kimura,Rie;etal.[Phytochemistry,1987,vol.26,#7,p.2071-2074]

[5]Sekizaki,Haruo[BulletinoftheChemicalSocietyofJapan,1988,vol.61,p.1407-1409]

[1]Mizota,Isao;Taniguchi,Kana;Shimizu,Makoto[Heterocycles,2016,vol.93,#1,p.310-322]

[2]Doportoetal.[JournaloftheChemicalSociety,1955,p.4249,4253]

90-24-4    120-14-9   
2'-hydroxy-3,4,4',6'-tetramethoxychalcone 

[1]Sipos,Zoltán;Kónya,Krisztina[Synthesis,2018,vol.50,#8,p.1610-1620]

[2]Singh,OmV.;Muthukrishnan;Sunderavadivelu[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2005,vol.44,#12,p.2575-2581]

[3]Chen,Lijuan;Fan,Tiantian;Lei,Xiangui;Teichmann,AlexanderTobias;Wang,Amu;Wang,Chao;Wei,Zhe;Wieland,FrankHeinrich;Yang,Youzhe;Yin,Jinxiang;Zhou,Li;Zhu,Yue[EuropeanJournalofMedicinalChemistry,2020,vol.193]

[4]CurrentPatentAssignee:SECONDMILITARYMEDICALUNIVERSITY-CN104230869,2016,BLocationinpatent:Paragraph0083;0084

[5]Locationinpatent:experimentalpartJuvale,Kapil;Pape,VeronikaF.S.;Wiese,Michael[BioorganicandMedicinalChemistry,2012,vol.20,#1,p.346-355]

[6]DeAzevedo,OrlandoD.C.C.;Seixas,RaquelS.G.R.;Silva,ArturM.S.[Synlett,2015,vol.26,#10,p.1379-1384]

[7]Locationinpatent:experimentalpartDetsi,Anastasia;Majdalani,Maya;Kontogiorgis,ChristosA.;Hadjipavlou-Litina,Dimitra;Kefalas,Panagiotis[BioorganicandMedicinalChemistry,2009,vol.17,#23,p.8073-8085]

[8]King;Robertson[JournaloftheChemicalSociety,1931,p.1704,1708]

[9]Reicheletal.[JustusLiebigsAnnalenderChemie,1942,vol.550,p.146,151]

[10]Parmar,V.S.;Sharma,Sunil;Rathore,J.S.;Garg,Meenu;Gupta,Sandhya;etal.[MagneticResonanceinChemistry,1990,vol.28,#5,p.470-474]

[11]Tanaka,Toshiyuki;Iinuma,Munekazu;Yuki,Kaoru;Fujii,Yuko;Mizuno,Mizuo[Phytochemistry,1992,vol.31,#3,p.993-998]

[12]Cabrera,Mauricio;Simoens,Macarena;Falchi,Gabriela;Lavaggi,M.Laura;Piro,OscarE.;Castellano,EduardoE.;Vidal,Anabel;Azqueta,Amaia;Monge,Antonio;deCerain,AdelaLopez;Sagrera,Gabriel;Seoane,Gustavo;Cerecetto,Hugo;Gonzalez,Mercedes[BioorganicandMedicinalChemistry,2007,vol.15,#10,p.3356-3367]

[13]Bakar,AddilaAbu;Akhtar,MuhammadNadeem;Ali,NorlailyMohd;Yeap,SweeKeong;Quah,ChingKheng;Loh,Wan-Sin;Alitheen,NoorjahanBanu;Zareen,Seema;Ul-Haq,Zaheer;Shah,SyedAdnanAli[Molecules,2018,vol.23,#3]

[14]Li,Cui;Wang,Gangqiang;Li,Xueli;Wang,Qiuan[MedicinalChemistryResearch,2018,vol.27,#3,p.972-979]

[1]Liu,Jianwen;Ma,Lei;Shi,Ximeng;Yin,Huanhuan;Zhao,Yuyu;Zhou,Licheng[Lettersindrugdesignanddiscovery,2020,vol.17,#10,p.1270-1282]

[2]Bakar,AddilaAbu;Akhtar,MuhammadNadeem;Ali,NorlailyMohd;Yeap,SweeKeong;Quah,ChingKheng;Loh,Wan-Sin;Alitheen,NoorjahanBanu;Zareen,Seema;Ul-Haq,Zaheer;Shah,SyedAdnanAli[Molecules,2018,vol.23,#3]

[3]Locationinpatent:experimentalpartNavarini,AndreiaLilianFormento;Chiaradia,LouiseDomeneghini;Mascarello,Alessandra;Fritzen,Marcio;Nunes,RicardoJose;Yunes,RosendoAugusto;Creczynski-Pasa,TaniaBeatriz[EuropeanJournalofMedicinalChemistry,2009,vol.44,#4,p.1630-1637]

[4]Chiaradia,LouiseDomeneghini;Mascarello,Alessandra;Purificacao,Marcela;Vernal,Javier;Cordeiro,MarlonNorbertoSechini;Zenteno,MariaEmilia;Villarino,Andrea;Nunes,RicardoJose;Yunes,RosendoAugusto;Terenzi,Hernan[BioorganicandMedicinalChemistryLetters,2008,vol.18,#23,p.6227-6230]

[5]Hsueetal.[TaiwanKexue,1959,vol.13,p.91,92][Chem.Abstr.,1960,p.4553]

[6]Locationinpatent:schemeortableBandgar,BabasahebP.;Patil,SachinA.;Gacche,RajeshN.;Korbad,BalajiL.;Hote,BalwantS.;Kinkar,SantoshN.;Jalde,ShivkumarS.[BioorganicandMedicinalChemistryLetters,2010,vol.20,#2,p.730-733]

[7]Locationinpatent:experimentalpartBello,MuriloLamim;Chiaradia,LouiseDomeneghini;Dias,LuizaRosariaSousa;Pacheco,LeticiaKramer;Stumpf,TaisaRegina;Mascarello,Alessandra;Steindel,Mario;Yunes,RosendoAugusto;Castro,HelenaCarla;Nunes,RicardoJose;Rodrigues,CarlosRangel[BioorganicandMedicinalChemistry,2011,vol.19,#16,p.5046-5052]

Literature

Title: Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria-Mediated Pathways.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: [Chemical constituents of Ammopiptanthus mongolicus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401

Title: Ellagic Acid, the Active Compound of Phyllanthus urinaria, Exerts In Vivo Anti-Angiogenic Effect and Inhibits MMP-2 Activity.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Evaluating interaction forces between BSA and rabbit anti-BSA in sulphathiazole sodium, tylosin and levofloxacin solution by AFM.

Journal: Nanoscale research letters 20110101

Title: Computer aided screening and evaluation of herbal therapeutics against MRSA infections.

Journal: Bioinformation 20110101

Title: Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.

Journal: European journal of medicinal chemistry 20100901

Title: [Phenols from Euphorbia humifusa].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301

Title: Antinociceptive and anti-inflammatory effects of ethanolic extracts of Glycine max (L.) Merr and Rhynchosia nulubilis seeds.

Journal: International journal of molecular sciences 20091101

Title: Antimicrobial phenolic compounds from Anabasis aphylla L.

Journal: Natural product communications 20090301

Title: Pharmacokinetics and tissue distribution of 8,9-epoxy brevifolin in rats, a hepatoprotective constituent isolated from Phyllanthus simplex Retz by liquid chromatography coupled with mass spectrometry method.

Journal: Biopharmaceutics & drug disposition 20080701

Title: [Chemical constituents of aerial part of Acalypha australis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

Title: [Studies on chemical constituents in roots of Euphorbia soongarica].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

Title: [Protecting effect of brevifolin and 8,9-single-epoxy brevifolin of Phyllanthus simplex on rat liver injury].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

Title: Antinociceptive effects of synthetic chalcones obtained from xanthoxyline.

Journal: Archiv der Pharmazie 20060701

Title: Molecular structure and QSAR study on antispasmodic activity of some xanthoxyline derivatives.

Journal: Archiv der Pharmazie 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis of chalcone analogues with increased antileishmanial activity.

Journal: Bioorganic & medicinal chemistry 20060301

Title: Antifungal activity and studies on mode of action of novel xanthoxyline-derived chalcones.

Journal: Archiv der Pharmazie 20050301

Title: Antifungal constituents of Melicope borbonica.

Journal: Phytotherapy research : PTR 20040701

Title: A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi.

Journal: Phytochemistry 20030901

Title: Frontal immunoaffinity chromatography with mass spectrometric detection: a method for finding active compounds from traditional Chinese herbs.

Journal: Analytical chemistry 20030815

Title: Antibacterial alkaloids from Zanthoxylum rhoifolium.

Journal: Planta medica 20030401

Title: Antifeedant constituents from Fagara macrophylla.

Journal: Fitoterapia 20010601

Title: Phenolic acids and depsides from some species of the Erodium genera.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101

Title: Fungicide and fungiostatic effects of xanthoxyline.

Journal: Journal of ethnopharmacology 19960901

Title: Cechinel Filho V, et al. Antispasmodic activity of xanthoxyline derivatives: structure-activity relationships.J Pharm Sci. 1995 Apr;84(4):473-5.

Title: Pinheiro TR, et al. In vitro antifungal evaluation and studies on the mode of action of xanthoxyline derivatives.Arzneimittelforschung. 1999 Dec;49(12):1039-43.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:90-24-4 Molecular Formula|90-24-4 MDL|90-24-4 SMILES|90-24-4 2'-Hydroxy-4',6'-dimethoxyacetophenone |Organic_Building_Blocks