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Home Other Building Blocks 934353-76-1
934353-76-1,MFCD16619371
Catalog No.:AA00GU0E

934353-76-1 | Enmd-2076

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$180.00   $126.00
- +
25mg
98%
in stock  
$466.00   $326.00
- +
100mg
≥99%
in stock  
$1,574.00   $1,102.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU0E
Chemical Name:
Enmd-2076
CAS Number:
934353-76-1
Molecular Formula:
C21H25N7
Molecular Weight:
375.4701
MDL Number:
MFCD16619371
SMILES:
CN1CCN(CC1)c1nc(/C=C/c2ccccc2)nc(c1)Nc1n[nH]c(c1)C
Properties
Computed Properties
 
Complexity:
499  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CASIPHARMACEUTICALSINC-WO2007/41358,2007,A2Locationinpatent:Page/Pagecolumn104

[2]CurrentPatentAssignee:CASIPHARMACEUTICALSINC-WO2007/41358,2007,A2Locationinpatent:Page/Pagecolumn99

[1]CurrentPatentAssignee:CASIPHARMACEUTICALSINC-WO2007/41358,2007,A2Locationinpatent:Page/Pagecolumn96

Literature

Title: ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action.

Journal: Molecular cancer therapeutics 20110101

Title: Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma.

Journal: British journal of haematology 20100801

Title: 3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: selective Aurora A kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Assessment of the in vivo antitumor effects of ENMD-2076, a novel multitargeted kinase inhibitor, against primary and cell line-derived human colorectal cancer xenograft models.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100601

Title: Discovery and development of aurora kinase inhibitors as anticancer agents.

Journal: Journal of medicinal chemistry 20090514

Title: Fletcher GC, et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37.

Title: Wang X, et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25.

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