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943-73-7,MFCD00002619
Catalog No.:AA0032E3

943-73-7 | L-Homophenylalanine

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Purity
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1g
98%
in stock  
$6.00   $4.00
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5g
98%
in stock  
$8.00   $6.00
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25g
98%
in stock  
$11.00   $8.00
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100g
98%
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$39.00   $28.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0032E3
Chemical Name:
L-Homophenylalanine
CAS Number:
943-73-7
Molecular Formula:
C10H13NO2
Molecular Weight:
179.2157
MDL Number:
MFCD00002619
SMILES:
N[C@H](C(=O)O)CCc1ccccc1
Properties
Properties
 
BP:
324.8 °C at 760 mmHg  
Form:
Solid  
MP:
>300 °C(lit.)  
Refractive Index:
44 ° (C=1, 3mol/L HCl)  
Solubility:
Soluble in dilute aqueous acid.  
Storage:
Light sensitive;Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
164  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
-1.2  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,1989,vol.32,#2,p.289-297

[2]JournalofMedicinalChemistry,1989,vol.32,#2,p.289-297

[1]JournalofMedicinalChemistry,1985,vol.28,#11,p.1596-1602

[2]Synthesis,2001,#7,p.1007-1009

[3]JournalofMedicinalChemistry,1989,vol.32,#2,p.289-297

[1]Patent:US4439364,1984,A,

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1986,vol.108,p.1103-1104

[1]JournalofMedicinalChemistry,1985,vol.28,p.1596-1602

[2]Synthesis,2001,p.1007-1009

[3]JournalofMedicinalChemistry,1989,vol.32,p.289-297

[1]JournalofOrganicChemistry,1990,vol.55,p.5567-5571

[2]JournalofMolecularCatalysisB:Enzymatic,2013,vol.88,p.26-31

[3]EuropeanJournalofOrganicChemistry,2019,vol.2019,p.6470-6477

[1]Bioorganicandmedicinalchemistryletters,2004,vol.14,p.275-278

[2]Patent:WO2004/20402,2004,A1.Locationinpatent:Page16

[3]Patent:WO2011/5322,2011,A2.Locationinpatent:Page/Pagecolumn68

[4]Patent:KR101595324,2016,B1.Locationinpatent:Paragraph0456

[5]JournaloftheAmericanChemicalSociety,2016,vol.138,p.8332-8335

[6]Patent:US9266846,2016,B2.Locationinpatent:Page/Pagecolumn47-48

(3E,2S)-2-amino-4-phenyl-3-butenoicacidhydrochloride 
  943-73-7 

[1]TetrahedronAsymmetry,2006,vol.17,p.2199-2202

Literature

Title: Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.

Journal: Biotechnology and bioengineering 20090401

Title: Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor.

Journal: Biotechnology advances 20090101

Title: Asymmetrically simultaneous synthesis of L-homophenylalanine and N6-protected-2-oxo-6-amino-hexanoic acid by engineered Escherichia coli aspartate aminotransferase.

Journal: Biotechnology progress 20090101

Title: A novel hydantoinase process using recombinant Escherichia coli cells with dihydropyrimidinase and L-N-carbamoylase activities as biocatalyst for the production of L-homophenylalanine.

Journal: Journal of biotechnology 20080430

Title: mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082.

Journal: Neuropharmacology 20070101

Title: Enantioselective synthesis of L-homophenylalanine by whole cells of recombinant Escherichia coli expressing L-aminoacylase and N-acylamino acid racemase genes from Deinococcus radiodurans BCRC12827.

Journal: Biotechnology progress 20060101

Title: Asymmetrical synthesis of L-homophenylalanine using engineered Escherichia coli aspartate aminotransferase.

Journal: Biotechnology progress 20050101

Title: Enantioselective synthesis of (S)-2-amino-4-phenylbutanoic acid by the hydantoinase method.

Journal: Chirality 20031001

Title: Asymmetric synthesis of L-homophenylalanine by equilibrium-shift using recombinant aromatic L-amino acid transaminase.

Journal: Biotechnology and bioengineering 20030720

Title: Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride.

Journal: Enantiomer 20020101

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