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945976-76-1,MFCD19443125
Catalog No.:AA00IIAV

945976-76-1 | Lx1031

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$174.00   $122.00
- +
5mg
≥98%
in stock  
$375.00   $263.00
- +
10mg
≥98%
in stock  
$613.00   $429.00
- +
25mg
≥98%
in stock  
$1,457.00   $1,020.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IIAV
Chemical Name:
Lx1031
CAS Number:
945976-76-1
Molecular Formula:
C28H25F3N4O4
Molecular Weight:
538.5177
MDL Number:
MFCD19443125
SMILES:
COc1cccc(c1)c1ccc(cc1)[C@H](C(F)(F)F)Oc1nc(N)nc(c1)c1ccc(cc1)C[C@@H](C(=O)O)N
Properties
Computed Properties
 
Complexity:
774  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
2.7  

Literature

Title: The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.

Journal: Gastroenterology 20110801

Title: Targeting serotonin synthesis to treat irritable bowel syndrome.

Journal: Gastroenterology 20110801

Title: LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110301

Title: LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome.

Journal: IDrugs : the investigational drugs journal 20101201

Title: Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200.

Title: Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8.

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