+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Other Building Blocks 948557-43-5
948557-43-5,MFCD14585804
Catalog No.:AA01DBJM

948557-43-5 | Tie2 kinase-IN-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$18.00   $13.00
- +
10mg
98%
in stock  
$66.00   $47.00
- +
50mg
98%
in stock  
$190.00   $133.00
- +
100mg
98%
in stock  
$323.00   $226.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01DBJM
Chemical Name:
Tie2 kinase-IN-1
CAS Number:
948557-43-5
Molecular Formula:
C26H21N3O2S
Molecular Weight:
439.5288
MDL Number:
MFCD14585804
SMILES:
COc1ccc2c(c1)ccc(c2)c1[nH]c(nc1c1ccncc1)c1ccc(cc1)S(=O)C
Properties
Computed Properties
 
Complexity:
635  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.3  

Downstream Synthesis Route
C26H21N3OS 
  948557-43-5 

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.4756-4760

948557-43-5   
(CH3)2CHCH2X 
  948557-47-9   
C30H29N3O2S 

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.4756-4760

948557-43-5   
EtX 
 
C28H25N3O2S 
  948557-46-8 

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.4756-4760

948557-43-5   
MeX 
 
C27H23O2N3S 
 
C27H23O2N3S 

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.4756-4760

948557-43-5   
nPrX 
  948557-48-0   
C29H27N3O2S 

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.4756-4760

Literature

Title: Efficacy of Tie2 receptor antagonism in angiosarcoma.

Journal: Neoplasia (New York, N.Y.) 20120201

Title: Optimization of triarylimidazoles for Tie2: influence of conformation on potency.

Journal: Bioorganic & medicinal chemistry letters 20071015

Title: Pyridinylimidazole inhibitors of Tie2 kinase.

Journal: Bioorganic & medicinal chemistry letters 20070901

Title: Semones M, et al. Pyridinylimidazole inhibitors of Tie2 kinase. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60. Epub 2007 Jun 27.

Title: Hasenstein JR, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012 Feb;14(2):131-40.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 948557-43-5
152121-47-6

152121-47-6

 152121-46-5

152121-46-5

 956613-01-7

956613-01-7
Building Blocks
More >
Tags:948557-43-5 Molecular Formula|948557-43-5 MDL|948557-43-5 SMILES|948557-43-5 Tie2 kinase-IN-1