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951-78-0,MFCD00006527
Catalog No.:AA005T2X

951-78-0 | 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

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5g
98%
in stock  
$14.00   $10.00
- +
10g
98%
in stock  
$24.00   $17.00
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25g
98%
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$53.00   $37.00
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100g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005T2X
Chemical Name:
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS Number:
951-78-0
Molecular Formula:
C9H12N2O5
Molecular Weight:
228.2020
MDL Number:
MFCD00006527
SMILES:
OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O
Properties
Properties
 
BP:
370.01°C (rough estimate)  
Form:
Solid  
MP:
167-169 °C(lit.)  
Refractive Index:
52 ° (C=1, 1mol/L NaOH)  
Stability:
Air Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
343  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-1.6  

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Title: Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.

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Title: Computational (DFT and TD DFT) study of the electron structure of the tautomers/conformers of uridine and deoxyuridine and the processes of intramolecular proton transfers.

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Title: Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.

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Title: Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.

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Title: Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives.

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Title: Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2'-deoxyuridines fluorometrically respond to hybridization.

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Title: 5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.

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Title: p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

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Title: Oligonucleotides containing 6-aza-2'-deoxyuridine: synthesis, nucleobase protection, pH-dependent duplex stability, and metal-DNA formation.

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Title: 123I-ITdU-mediated nanoirradiation of DNA efficiently induces cell kill in HL60 leukemia cells and in doxorubicin-, beta-, or gamma-radiation-resistant cell lines.

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Title: High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny.

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Title: 5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells.

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Title: A kinetic and thermodynamic study of the glycosidic bond cleavage in deoxyuridine.

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Title: Characterization and mechanism of formation of tandem lesions in DNA by a nucleobase peroxyl radical.

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Title: 5-Propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides.

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Title: Modified DNA aptamer that binds the (R)-isomer of a thalidomide derivative with high enantioselectivity.

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Title: Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients.

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Title: Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy.

Journal: The Journal of biological chemistry 20060811

Title: Absence of an immediate G1/S checkpoint in primary MEFs following gamma-irradiation identifies a novel checkpoint switch.

Journal: Cell cycle (Georgetown, Tex.) 20060801

Title: Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

Journal: Journal of medicinal chemistry 20060713

Title: Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293.

Journal: Chemical research in toxicology 20060701

Title: Synthesis and mutagenesis of the butadiene-derived N3 2'-deoxyuridine adducts.

Journal: Chemical research in toxicology 20060701

Title: The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse.

Journal: Biochemistry 20060627

Title: Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

Journal: British journal of cancer 20060619

Title: DNA and LNA oligonucleotides containing N2'-functionalised derivatives of 2'-amino-2'-deoxyuridine.

Journal: Bioorganic & medicinal chemistry letters 20060615

Title: Facile photocyclization chemistry of 5-phenylthio-2'-deoxyuridine in duplex DNA.

Journal: Organic letters 20060608

Title: DNA as a supramolecular scaffold for the helical arrangement of a stack of 1-ethynylpyrene chromophores.

Journal: Organic & biomolecular chemistry 20060607

Title: Characterization of BlsM, a nucleotide hydrolase involved in cytosine production for the biosynthesis of blasticidin S.

Journal: Chembiochem : a European journal of chemical biology 20060601

Title: 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.

Journal: Journal of medicinal chemistry 20060601

Title: Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.

Journal: Carcinogenesis 20060501

Title: Fluorescent 5-alkynyl-2'-deoxyuridines: high emission efficiency of a conjugated perylene nucleoside in a DNA duplex.

Journal: Chembiochem : a European journal of chemical biology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: In vitro anti-mycobacterial activities of various 2'-deoxyuridine, 2'-arabinouridine and 2'-arabinofluoro-2'-deoxyuridine analogues: synthesis and biological studies.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20060501

Title: Syntheses of pyridine C-nucleosides as analogues of the natural nucleosides dC and dU.

Journal: The Journal of organic chemistry 20060331

Title: 5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.

Journal: Organic & biomolecular chemistry 20060321

Title: DNA intramolecular triplexes containing dT --> dU substitutions: unfolding energetics and ligand binding.

Journal: Biochemistry 20060307

Title: Mitochondrial neurogastrointestinal encephalomyopathy: evidence of mitochondrial DNA depletion in the small intestine.

Journal: Gastroenterology 20060301

Title: 3'-N-Alkylamino-3'-deoxy-ara-uridines: a new class of potential inhibitors of ribonuclease A and angiogenin.

Journal: Bioorganic & medicinal chemistry 20060215

Title: 3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: Synthesis of oligonucleotides with 3'-terminal 5-(3-acylamidopropargyl)-3'-amino-2',3'-dideoxyuridine residues and their reactivity in single-nucleotide steps of chemical replication.

Journal: The Journal of organic chemistry 20060203

Title: Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants.

Journal: Journal of enzyme inhibition and medicinal chemistry 20060201

Title: Oxygen independent DNA interstrand cross-link formation by a nucleotide radical.

Journal: Journal of the American Chemical Society 20060118

Title: Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide.

Journal: Chemical research in toxicology 20060101

Title: Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20060101

Title: Viruses take center stage in cellular evolution.

Journal: Genome biology 20060101

Title: [Study of drugs against neoplastic metastasis].

Journal: Magyar onkologia 20060101

Title: A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.

Journal: Journal of experimental botany 20060101

Title: [Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)].

Journal: Casopis lekaru ceskych 20060101

Title: Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.

Journal: Antiviral chemistry & chemotherapy 20060101

Title: Nucleotide insertion opposite a cyclobutane pyrimidine dimer analogue caused from photoligation by a replicative DNA polymerase.

Journal: Nucleic acids symposium series (2004) 20060101

Title: Synthesis and properties of novel PRODAN-labeled uridine.

Journal: Nucleic acids symposium series (2004) 20060101

Title: [The innate antiretroviral defense of human cells, based on the DNA editing].

Journal: Postepy biochemii 20060101

Title: Paradigm development: comparative and predictive 3D modeling of HIV-1 Virion Infectivity Factor (Vif).

Journal: Bioinformation 20060101

Title: Synthesis of a 2'-Se-uridine phosphoramidite and its incorporation into oligonucleotides for structural study.

Journal: Organic letters 20051208

Title: Comparison of Py*+/dU*- charge transfer state dynamics in 5-(1-pyrenyl)-2'-deoxyuridine nucleoside conjugates with amido-, ethylenyl-, and ethynyl linkers.

Journal: The journal of physical chemistry. A 20051208

Title: Synthesis and in vitro antileishmanial activity of 5-substituted-2'-deoxyuridine derivatives.

Journal: Bioorganic chemistry 20051201

Title: Yersiniophage phiR1-37 is a tailed bacteriophage having a 270 kb DNA genome with thymidine replaced by deoxyuridine.

Journal: Microbiology (Reading, England) 20051201

Title: Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2'-deoxyuridine and 5-chloro-2'-deoxyuridine.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20051101

Title: Emx2 regulates mammalian reproduction by altering endometrial cell proliferation.

Journal: Molecular endocrinology (Baltimore, Md.) 20051101

Title: Increased muscle nucleoside levels associated with a novel frameshift mutation in the thymidine phosphorylase gene in a Spanish patient with MNGIE.

Journal: Neuromuscular disorders : NMD 20051101

Title: Nucleic acid with guanidinium modification exhibits efficient cellular uptake.

Journal: Angewandte Chemie (International ed. in English) 20051021

Title: A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.

Journal: British journal of cancer 20051017

Title: Late-onset MNGIE due to partial loss of thymidine phosphorylase activity.

Journal: Annals of neurology 20051001

Title: Site-selective DNA hydrolysis by Ce(IV)-EDTA with the use of one oligonucleotide additive bearing two monophosphates.

Journal: Chembiochem : a European journal of chemical biology 20051001

Title: Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target.

Journal: Journal of medicinal chemistry 20050922

Title: Incorporation of cationic chains in the Dickerson-Drew dodecamer: correlation of energetics, structure, and ion and water binding.

Journal: Biochemistry 20050920

Title: Electron transfer chemistry between DNA and DNA-binding tripeptides.

Journal: Biochemistry 20050906

Title: The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells.

Journal: Journal of neuro-oncology 20050901

Title: Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050801

Title: Oxidation of 5-hydroxypyrimidine nucleosides to 5-hydroxyhydantoin and its alpha-hydroxy-ketone isomer.

Journal: Chemical research in toxicology 20050801

Title: Thymidine phosphorylase mutations cause instability of mitochondrial DNA.

Journal: Gene 20050718

Title: Photoinduced DNA end capping via N3-methyl-5-cyanovinyl-2'-deoxyuridine.

Journal: Chemical communications (Cambridge, England) 20050707

Title: Template-directed DNA photoligation via alpha-5-cyanovinyldeoxyuridine.

Journal: Organic letters 20050707

Title: Mitochondrial deoxynucleotide pools in quiescent fibroblasts: a possible model for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).

Journal: The Journal of biological chemistry 20050701

Title: Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase.

Journal: Structure (London, England : 1993) 20050701

Title: Charge transfer excited-state dynamics in DNA duplexes substituted with an ethynylpyrenyldeoxyuridine electron source and a fluorodeoxyuridine electron trap.

Journal: The journal of physical chemistry. B 20050623

Title: ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.

Journal: Biochimica et biophysica acta 20050615

Title: Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050615

Title: Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050605

Title: Proton affinity ladder for uridine and analogs: influence of the hydroxyl group on the sugar ring conformation.

Journal: Journal of mass spectrometry : JMS 20050601

Title: A dual selection based, targeted gene replacement tool for Magnaporthe grisea and Fusarium oxysporum.

Journal: Fungal genetics and biology : FG & B 20050601

Title: Structure of B-DNA with cations tethered in the major groove.

Journal: Biochemistry 20050524

Title: beta-Selective synthesis of 2'-deoxy-5,6-dihydro-4-thiouridine, a precursor of the unstable nucleoside product of ionising radiation damage 2'-deoxy-5,6-dihydrocytidine.

Journal: Organic & biomolecular chemistry 20050507

Title: Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.

Journal: Current biology : CB 20050412

Title: Determining the origin of the stabilization of DNA by 5-aminopropynylation of pyrimidines.

Journal: Biochemistry 20050329

Title: Reductive electron transfer in phenothiazine-modified DNA is dependent on the base sequence.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20050304

Title: Differential incorporation of halogenated deoxyuridines during UV-induced DNA repair synthesis in human cells.

Journal: DNA repair 20050302

Title: Rapid identification of emerging pathogens: coronavirus.

Journal: Emerging infectious diseases 20050301

Title: Phosphodiester cleavage of guanylyl-(3',3')-(2'-amino-2'-deoxyuridine): rate acceleration by the 2'-amino function.

Journal: Journal of the American Chemical Society 20050216

Title: A phase II study of raltitrexed and gemcitabine in patients with advanced pancreatic carcinoma.

Journal: British journal of cancer 20050214

Title: The fate of heterologous CD4+ T cells during Leishmania donovani infection.

Journal: European journal of immunology 20050201

Title: dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

Journal: Structure (London, England : 1993) 20050201

Title: Active site plasticity of endonuclease V from Salmonella typhimurium.

Journal: Biochemistry 20050118

Title: A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells.

Journal: Bioorganic & medicinal chemistry letters 20050103

Title: APOBEC3G & HTLV-1: inhibition without deamination.

Journal: Retrovirology 20050101

Title: Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast.

Journal: BMC genetics 20050101

Title: APOBEC3G targets human T-cell leukemia virus type 1.

Journal: Retrovirology 20050101

Title: Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.

Journal: Virology journal 20050101

Title: CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.

Journal: BMC bioinformatics 20050101

Title: Use of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy.

Journal: Retrovirology 20050101

Title: Megaloblastosis: from morphos to molecules.

Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101

Title: Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomono phosphate as a potential thymidylate synthase inhibitor.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame.

Journal: Virology journal 20050101

Title: Immunohistochemical detection of dUTPase in intracranial tumors.

Journal: Pathology, research and practice 20050101

Title: [Synthesis and antiviral activity of new 5-substituted 2'-deoxyuridine derivatives].

Journal: Bioorganicheskaia khimiia 20050101

Title: Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture.

Journal: Journal of biomedicine & biotechnology 20050101

Title: DNA interstrand cross-links from modified nucleotides: mechanism and application.

Journal: Nucleic acids symposium series (2004) 20050101

Title: Pyrene-labeled deoxyuridine and deoxyadenosine: fluorescent discriminating phenomena in their duplex and hairpin oligonucleotides.

Journal: Nucleic acids symposium series (2004) 20050101

Title: RNA template-directed photoligation via 5-carboxyvinyl-2'-deoxyuridine.

Journal: Nucleic acids symposium series (2004) 20050101

Title: Reactivity of 2'-deoxyuridin-1'-yl radical in various DNA structures.

Journal: Nucleic acids symposium series (2004) 20050101

Title: SNPs typing by base-discriminating fluorescence DNA probe.

Journal: Nucleic acids symposium series (2004) 20050101

Title: Mild generation of 5-(2'-deoxyuridinyl)methyl radical from a phenyl selenide precursor.

Journal: Organic letters 20041223

Title: Induction of gene mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue.

Journal: Mutation research 20041221

Title: Induction of A:T to G:C transition mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue, in the bone marrow of Muta Mouse.

Journal: Mutation research 20041221

Title: Three-dimensional structure of the R115E mutant of T4-bacteriophage 2'-deoxycytidylate deaminase.

Journal: Biochemistry 20041102

Title: In vivo evidence for apoptosis, but not inflammation in the hindlimb muscle of neuropathic rats.

Journal: Pain 20041101

Title: A homogeneous time-resolved fluorescence detection of telomerase activity.

Journal: Analytical biochemistry 20041001

Title: Calorimetric determination of thermodynamic parameters of 2'-dUMP binding to Leishmania major dUTPase.

Journal: Biochimica et biophysica acta 20041001

Title: Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.

Journal: Journal of natural products 20041001

Title: Thymidine phosphorylase deficiency causes MNGIE: an autosomal recessive mitochondrial disorder.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Stabilizing or destabilizing oligodeoxynucleotide duplexes containing single 2'-deoxyuridine residues with 5-alkynyl substituents.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040820

Title: Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

Journal: Biochemical pharmacology 20040815

Title: Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040801

Title: Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma.

Journal: Gut 20040801

Title: Endogenous expression of activation-induced cytidine deaminase in cell line WEHI-231.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040801

Title: Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes.

Journal: Analytical biochemistry 20040701

Title: Oxidation of 5-hydroxy-2'-deoxyuridine into isodialuric acid, dialuric acid, and hydantoin products.

Journal: Journal of the American Chemical Society 20040602

Title: Pyrene-labeled base-discriminating fluorescent DNA probes for homogeneous SNP typing.

Journal: Journal of the American Chemical Society 20040421

Title: The regulation of somatic hypermutation.

Journal: Current opinion in immunology 20040401

Title: Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040401

Title: Effect of GLP-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion.

Journal: Pancreas 20040301

Title: Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218

Title: Lysine directed cross-linking of viral DNA-RNA:DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase.

Journal: Biochemistry 20040210

Title: The first direct evaluation of the two-active site mechanism for chitin synthase.

Journal: The Journal of organic chemistry 20040206

Title: In vitro and in vivo evaluation of novel antitumor prodrugs of 5-fluoro-2'-deoxyuridine activated by hypoxic irradiation.

Journal: International journal of radiation oncology, biology, physics 20040201

Title: Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

Journal: European journal of immunology 20040201

Title: Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity.

Journal: British journal of cancer 20040126

Title: ND5 is a hot-spot for multiple atypical mitochondrial DNA deletions in mitochondrial neurogastrointestinal encephalomyopathy.

Journal: Human molecular genetics 20040101

Title: Definitive diagnosis of mitochondrial neurogastrointestinal encephalomyopathy by biochemical assays.

Journal: Clinical chemistry 20040101

Title: Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a disease of two genomes.

Journal: The neurologist 20040101

Title: Use of folic acid casei medium reveals trimethoprim susceptibility of Lactobacillus species.

Journal: Letters in applied microbiology 20040101

Title: Relationship of cell proliferation (Ki-67) to 99mTc-(V)DMSA uptake in breast cancer.

Journal: Breast cancer research : BCR 20040101

Title: A new approach for the synthesis of novel 5-substituted isodeoxyuridine analogs.

Journal: Nucleosides, nucleotides & nucleic acids 20040101

Title: Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine.

Journal: Nucleosides, nucleotides & nucleic acids 20040101

Title: Molecular modeling of the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

Journal: Nucleosides, nucleotides & nucleic acids 20040101

Title: Tissue-specific spatial organization of genomes.

Journal: Genome biology 20040101

Title: [Monomers for oligonucleotide synthesis with linkers carrying reactive residues: II. Synthesis of phosphoamidites based of uridine and cytosine and containing a linker with methoxyoxalamide groups in position 2'].

Journal: Bioorganicheskaia khimiia 20040101

Title: Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells.

Journal: Retrovirology 20040101

Title: [Antisense oligonucleotides with antitumor activity].

Journal: Magyar onkologia 20040101

Title: [Potentiation of 5-fluorouracil efficacy. Molecular mechanisms playing a role in the cytotoxic action of 5-fluorouracil and 5-ethyl-2'-deoxyuridine (EUdR) combination].

Journal: Magyar onkologia 20040101

Title: Immobilization and stabilization of recombinant multimeric uridine and purine nucleoside phosphorylases from Bacillus subtilis.

Journal: Biomacromolecules 20040101

Title: Reversible DNA photoligation via alpha-5-cyanovinyldeoxyuridine.

Journal: Nucleic acids symposium series (2004) 20040101

Title: X-ray analyses of DNA duplexes containing 5-(N-aminohexyl)carbamoyl modifications.

Journal: Nucleic acids symposium series (2004) 20040101

Title: Novel low-molecular-weight hydrogelators based on 2'-deoxyuridine.

Journal: Chemical communications (Cambridge, England) 20031207

Title: Replication labeling patterns and chromosome territories typical of mammalian nuclei are conserved in the early metazoan Hydra.

Journal: Chromosoma 20031201

Title: The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.

Journal: Nature medicine 20031101

Title: Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth.

Journal: Molecular microbiology 20031101

Title: Independent generation of 5-(2'-deoxycytidinyl)methyl radical and the formation of a novel cross-link lesion between 5-methylcytosine and guanine.

Journal: Journal of the American Chemical Society 20031022

Title: Regulation of bovine corneal endothelial cell cycle by transforming growth factor-beta.

Journal: Acta ophthalmologica Scandinavica 20031001

Title: Pharmacokinetics and metabolism of 5-125I-iodo-4'-thio-2'-deoxyuridine in rodents.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031001

Title: Proliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol.

Journal: Toxicology and applied pharmacology 20031001

Title: Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations.

Journal: Chemical research in toxicology 20030901

Title: Aggregation of RecA-derived peptides on single-stranded oligonucleotides triggered by schiff base-mediated crosslinking.

Journal: Bioorganic & medicinal chemistry letters 20030901

Title: 5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay.

Journal: The Journal of biological chemistry 20030829

Title: Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

Journal: British journal of cancer 20030804

Title: Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.

Journal: Chembiochem : a European journal of chemical biology 20030804

Title: Identification of a novel human uridine phosphorylase.

Journal: Biochemical and biophysical research communications 20030718

Title: Modified DNA bearing 5(methoxycarbonylmethyl)-2'-deoxyuridine: preparation by PCR with thermophilic DNA polymerase and postsynthetic derivatization.

Journal: Chembiochem : a European journal of chemical biology 20030707

Title: Conformational structures and vibrational spectra of isolated pyrimidine nucleosides: Fourier transform infrared matrix isolation study of 2-deoxyuridine.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030701

Title: Photochemical cross-linking of Escherichia coli Fpg protein to DNA duplexes containing phenyl(trifluoromethyl)diazirine groups.

Journal: European journal of biochemistry 20030701

Title: Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders.

Journal: Clinical chemistry and laboratory medicine 20030701

Title: Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines.

Journal: British journal of cancer 20030616

Title: Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency.

Journal: The Journal of clinical investigation 20030615

Title: DNA deamination mediates innate immunity to retroviral infection.

Journal: Cell 20030613

Title: Immunomodulation of hepatic ischemic injury via increased Bcl-X(L) and decreased Bcl-X(S).

Journal: The Journal of surgical research 20030601

Title: Synthesis and enzymatic transformations of 5-halo-6-methoxy-5,6-dihydro derivatives of 5-[1-methoxy-2-halo (or 2,2-dihalo)ethyl]-2'-deoxyuridines as potential herpes simplex virus inhibitors.

Journal: Journal of enzyme inhibition and medicinal chemistry 20030601

Title: Independent generation and study of 5,6-Dihydro-2'-deoxyuridin-6-yl, a member of the major family of reactive intermediates formed in DNA from the effects of gamma-radiolysis.

Journal: The Journal of organic chemistry 20030530

Title: 2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.

Journal: Journal of the National Cancer Institute 20030507

Title: Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges.

Journal: Organic & biomolecular chemistry 20030507

Title: Synthesis, solution conformation and anti-HIV activity of novel 3'-substituted-2',3'-dideoxy-5-hydroxymethyluridines and their 4,5-substituted analogues.

Journal: Antiviral chemistry & chemotherapy 20030501

Title: Oligo-2'-deoxyribonucleotides containing uracil modified at the 5-position with linkers ending with guanidinium groups.

Journal: Journal of the American Chemical Society 20030416

Title: A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030401

Title: The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase.

Journal: The Journal of biological chemistry 20030328

Title: Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiency.

Journal: Biochemical and biophysical research communications 20030328

Title: Effect of pH and sodium chloride on the strength and selectivity of the interaction of gamma [correction for tau] -cyclodextrin with some antisense nucleosides.

Journal: International journal of pharmaceutics 20030326

Title: DFT analysis of NMR scalar interactions across the glycosidic bond in DNA.

Journal: Journal of the American Chemical Society 20030326

Title: Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: 'nitric oxide donor' agents for evaluation as anticancer and antiviral agents.

Journal: Journal of medicinal chemistry 20030313

Title: A balanced deoxyribonucleoside mixture increased the rate of DNA incorporation of 5-[125I]Iodo-2'-deoxyuridine in glioblastoma cells.

Journal: Cancer biotherapy & radiopharmaceuticals 20030201

Title: Pathways of accumulation and repair of deoxyuridine residues in DNA of higher and lower organisms.

Journal: Biochemistry. Biokhimiia 20030201

Title: Evaluation of 5-[1-(2-halo(or nitro)ethoxy-2-iodoethyl)]-2'-deoxyuridines as inhibitors of herpes simplex virus.

Journal: Journal of enzyme inhibition and medicinal chemistry 20030201

Title: Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies.

Journal: Bioorganic & medicinal chemistry 20030102

Title: Microwave-assisted synthesis of O'-adamantylated uracil-derived nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Synthesis of a novel aldehyde: 4-O-methyl-5-formylmethyl-2'-deoxyuridine.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: The effects of middle cerebral artery occlusion on central nervous system apoptotic events in normal and diabetic rats.

Journal: International journal of experimental diabesity research 20030101

Title: [Effects of childhood nutrition on adult health].

Journal: Allergologia et immunopathologia 20030101

Title: [Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives].

Journal: Bioorganicheskaia khimiia 20030101

Title: The NMR studies of substituent effects on the N-H...N hydrogen bond in duplex DNA using 2'-deoxynebularine and 15N labeled 5-substituted-2'-deoxyuridine base pairs.

Journal: Nucleic acids research. Supplement (2001) 20030101

Title: Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Synthesis of modified DNAs bearing two different fluorescent probes and its application to fluorescence resonance energy transfer.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Hydrolytic reactions of diribonucleoside 3',5'-(3'-N-phosphoramidates): kinetics and mechanisms for the P-O and P-N bond cleavage of 3'-amino-3'-deoxyuridylyl-3',5'-uridine.

Journal: Journal of the American Chemical Society 20021204

Title: DNA duplexes containing photoactive derivatives of 2'-deoxyuridine as photocrosslinking probes for EcoRII DNA methyltransferase-substrate interaction.

Journal: Journal of biomolecular structure & dynamics 20021201

Title: Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE).

Journal: Journal of inherited metabolic disease 20021101

Title: Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3'-deoxycytidine.

Journal: Antiviral chemistry & chemotherapy 20021101

Title: 5-amino-2'-deoxyuridine, a novel thymidine analogue for high-resolution footprinting of protein-DNA complexes.

Journal: Organic letters 20021031

Title: Radiolabelled thymidines and deoxyuridines for measuring cellular proliferation in tumours--an update.

Journal: Nuclear medicine communications 20021001

Title: Synthesis of 5-(pyridinyl and pyridiniumyl)-2'-deoxyuridine nucleosides: reversible electron traps for DNA.

Journal: Nucleosides, nucleotides & nucleic acids 20021001

Title: Rationale of 5-(125)I-iodo-4'-thio-2'-deoxyuridine as a potential iodinated proliferation marker.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020901

Title: Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

Journal: FEBS letters 20020828

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Journal: The Journal of biological chemistry 19940722

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Journal: Biochemical pharmacology 19940429

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Journal: International journal of radiation oncology, biology, physics 19940330

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Journal: Journal of medicinal chemistry 19930820

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Journal: Journal of medicinal chemistry 19910801

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Journal: Journal of medicinal chemistry 19910601

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Journal: Journal of medicinal chemistry 19910401

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Journal: Journal of medicinal chemistry 19900201

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Journal: Proceedings of the National Academy of Sciences of the United States of America 19890201

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Journal: The Journal of biological chemistry 19871105

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Journal: Journal of medicinal chemistry 19870701

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Journal: Journal of medicinal chemistry 19860101

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Journal: Journal of medicinal chemistry 19851101

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Journal: Antimicrobial agents and chemotherapy 19850801

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Journal: Journal of medicinal chemistry 19850501

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Journal: Antiviral research 19850201

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Journal: Antiviral research 19830901

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Journal: Journal of medicinal chemistry 19830201

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Journal: Journal of medicinal chemistry 19821101

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SDS
Tags:951-78-0 Molecular Formula|951-78-0 MDL|951-78-0 SMILES|951-78-0 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione |Heterocyclic_Building_Blocks