Home Amines 958772-66-2
958772-66-2,MFCD16875433
Catalog No.:AA01ENM9

958772-66-2 | N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$375.00   $263.00
- +
10mg
95%
in stock  
$552.00   $387.00
- +
25mg
95%
in stock  
$1,172.00   $820.00
- +
50mg
95%
in stock  
$1,790.00   $1,253.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01ENM9
Chemical Name:
N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
CAS Number:
958772-66-2
Molecular Formula:
C27H33N5O5S
Molecular Weight:
539.6464
MDL Number:
MFCD16875433
SMILES:
CCc1ccccc1NC(=O)CSC(=O)NNC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)OC(C)(C)C
Properties
Computed Properties
 
Complexity:
835  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
11  
XLogP3:
4.5  

Literature

Title: Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy.

Journal: PLoS pathogens 20120501

Title: Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.

Journal: Bioorganic & medicinal chemistry letters 20080615

Title: Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20080101

Title: Shah PP, et al. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol. 2008 Jul;74(1):34-41.

Title: Pribis JP, et al. The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88. Mol Med. 2015 Dec;21(1):749-757.

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Tags:958772-66-2 Molecular Formula|958772-66-2 MDL|958772-66-2 SMILES|958772-66-2 N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide