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968-81-0,MFCD00072156
Catalog No.:AA005SG7

968-81-0 | Acetohexamide

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50mg
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$46.00   $32.00
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250mg
≥98%
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$86.00   $60.00
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1g
≥98%
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5g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005SG7
Chemical Name:
Acetohexamide
CAS Number:
968-81-0
Molecular Formula:
C15H20N2O4S
Molecular Weight:
324.3953
MDL Number:
MFCD00072156
SMILES:
O=C(NS(=O)(=O)c1ccc(cc1)C(=O)C)NC1CCCCC1
NSC Number:
759128
Properties
Properties
 
Form:
Solid  
MP:
>175°C (dec.)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
498  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.4  

Literature

Title: Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3).

Journal: Chemico-biological interactions 20150605

Title: Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus.

Journal: Molecules (Basel, Switzerland) 20140711

Title: Epac2: a sulfonylurea receptor?

Journal: Biochemical Society transactions 20120201

Title: The management of type 2 diabetic patients with hypoglycaemic agents.

Journal: ISRN endocrinology 20120101

Title: Detection of heterogeneous drug-protein binding by frontal analysis and high-performance affinity chromatography.

Journal: Journal of chromatography. A 20111209

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Use of peak decay analysis and affinity microcolumns containing silica monoliths for rapid determination of drug-protein dissociation rates.

Journal: Journal of chromatography. A 20110415

Title: Extended hildebrand solubility approach: satranidazole in mixtures of dioxane and water.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Chromatographic studies of changes in binding of sulfonylurea drugs to human serum albumin due to glycation and fatty acids.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Chromatographic analysis of acetohexamide binding to glycated human serum albumin.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015

Title: Pancreatic beta-cell signaling: toward better understanding of diabetes and its treatment.

Journal: Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100611

Title: Characterization of the binding of sulfonylurea drugs to HSA by high-performance affinity chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

Title: A new method of urethroplasty for prevention of fistula in female-to-male gender reassignment surgery.

Journal: Annals of plastic surgery 20100601

Title: Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.

Journal: Clinical pharmacology : advances and applications 20100101

Title: Rosiglitazone and myocardial infarction in patients previously prescribed metformin.

Journal: PloS one 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

Journal: Diabetes care 20081101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Differential pharmacokinetics of acetohexamide in male Wistar-Imamichi and Sprague-Dawley rats: role of microsomal carbonyl reductase.

Journal: Biological & pharmaceutical bulletin 20050101

Title: [Studies for analyzing the prohibited ingredients such as acetohexamide in cosmetics].

Journal: Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20050101

Title: Strain- and sex-related differences of carbonyl reductase activities in kidney microsomes and cytosol of rats.

Journal: Journal of applied toxicology : JAT 20040101

Title: Analysis of synthetic anti-diabetic drugs in adulterated traditional Chinese medicines by high-performance capillary electrophoresis.

Journal: Journal of pharmaceutical and biomedical analysis 20030919

Title: Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030801

Title: Barriers to self-monitoring of blood glucose among adults with diabetes in an HMO: a cross sectional study.

Journal: BMC health services research 20030101

Title: [A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus].

Journal: Yakushigaku zasshi 20030101

Title: Sex-dependent pharmacokinetics of S(-)-hydroxyhexamide, a pharmacologically active metabolite of acetohexamide, in rats.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20021201

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity.

Journal: Archives of toxicology 20020201

Title: Hormonal regulation of male-specific 20beta-hydroxysteroid dehydrogenase with carbonyl reductase-like activity present in kidney microsomes of rats.

Journal: The Journal of steroid biochemistry and molecular biology 20011001

Title: Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide.

Journal: Life sciences 20010907

Title: [Strain-, sex- and species-related differences of acetohexamide reductase and 20 beta-hydroxysteroid dehydrogenase activities in liver microsomes of experimental animals].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101

Title: The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.

Journal: Journal of molecular endocrinology 19990401

Title: Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.

Journal: Science (New York, N.Y.) 19951117

Title: Reversible cholestatic hepatitis caused by acetohexamide.

Journal: Gastroenterology 19890601

Title: Reduction of the severity of nephropathy in aging Fischer 344 rats treated with analogs of arylsulfonyluria.

Journal: Toxicology and applied pharmacology 19790701

Title: Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.

Journal: Clinical pharmacokinetics 19760101

Title: Prolonged coma after acetohexamide ingestion.

Journal: JAMA 19670710

Title: Hypoglycemic stupor caused by acetohexamide.

Journal: The New England journal of medicine 19660602

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