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99291-25-5,MFCD00866852
Catalog No.:AA006OKJ

99291-25-5 | (S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol

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Purity
Availability
Price(USD)
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100mg
97%
in stock  
$6.00   $4.00
- +
1g
98%(GC)
in stock  
$34.00   $24.00
- +
25g
97%
in stock  
$71.00   $50.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA006OKJ
Chemical Name:
(S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
CAS Number:
99291-25-5
Molecular Formula:
C13H20N2O2
Molecular Weight:
236.3101
MDL Number:
MFCD00866852
SMILES:
OC[C@H](CN1CCN(CC1)c1ccccc1)O
Properties
Properties
 
Form:
Solid  
MP:
103-105˚C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
212  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
0.6  

Downstream Synthesis Route

[1]Giani;Marinone;Melillo;Borsa;Tonon[Arzneimittel-Forschung/DrugResearch,1988,vol.38,#8,p.1139-1141]

[1]Giani;Marinone;Melillo;Borsa;Tonon[Arzneimittel-Forschung/DrugResearch,1988,vol.38,#8,p.1139-1141]

99291-25-5    25561-30-2   
1-((S)-2,3-Bis-trimethylsilanyloxy-propyl)-4-phenyl-piperazine 

[1]Zaratin;DeAngelis;Cattabeni[Arzneimittel-Forschung/DrugResearch,1988,vol.38,#8,p.1156-1158]

1-benzoyloxy-3-(4-phenyl-piperazin-1-yl)-2-propanol 
  99291-25-5   
dextrodropropizine 

[1]Caselli,Emilia;Tosi,Giovanni;Forni,Arrigo;Bucciarelli,Maria;Prati,Fabio[IlFarmaco,2003,vol.58,#10,p.1029-1032]

Literature

Title: Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20131201

Title: Efficacy of levodropropizine in pediatric cough.

Journal: Pulmonary pharmacology & therapeutics 20121001

Title: An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome.

Journal: Cough (London, England) 20120101

Title: Antitussive effect of naringin on experimentally induced cough in Guinea pigs.

Journal: Planta medica 20110101

Title: Pharmacological and clinical overview of cloperastine in treatment of cough.

Journal: Therapeutics and clinical risk management 20110101

Title: Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review.

Journal: Journal of pain & palliative care pharmacotherapy 20110101

Title: Cough management: a practical approach.

Journal: Cough (London, England) 20110101

Title: Interventions for cough in cancer.

Journal: The Cochrane database of systematic reviews 20100908

Title: An anaphylactic reaction caused by levodropropizine.

Journal: Allergy 20100301

Title: Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.

Journal: International journal of analytical chemistry 20100101

Title: Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough.

Journal: Cough (London, England) 20100101

Title: The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.

Journal: Bratislavske lekarske listy 20090101

Title: Currently available cough suppressants for chronic cough.

Journal: Lung 20080101

Title: HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.

Journal: Archives of pharmacal research 20060601

Title: Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

Title: [Determination of levodropropizine and its pharmacokinetics in human plasma using LC/MS/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041201

Title: Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Journal: Therapeutic drug monitoring 20040801

Title: Antitussive effect of diltiazem in experimental conditions.

Journal: Bratislavske lekarske listy 20040101

Title: Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

Journal: Drugs under experimental and clinical research 20040101

Title: Chemo-enzymatic synthesis of levodropropizine.

Journal: Farmaco (Societa chimica italiana : 1989) 20031001

Title: Levodropropizine does not affect P0.1 and breathing pattern in healthy volunteers and patients with chronic respiratory impairment.

Journal: Pulmonary pharmacology & therapeutics 20030101

Title: Important drugs for cough in advanced cancer.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20011101

Title: Zanasi A, et al. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidiscip Respir Med. 2015 May 31;10(1):19.

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