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Home Fluorides 203866-15-3
203866-15-3,MFCD03094917
Catalog No.:AA00292X

203866-15-3 | N-Boc-4,4-difluoro-l-proline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
97%
in stock  
$6.00   $4.00
- +
1g
95%
in stock  
$18.00   $13.00
- +
5g
97%
in stock  
$37.00   $26.00
- +
10g
97%
in stock  
$45.00   $32.00
- +
25g
97%
in stock  
$111.00   $78.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00292X
Chemical Name:
N-Boc-4,4-difluoro-l-proline
CAS Number:
203866-15-3
Molecular Formula:
C10H15F2NO4
Molecular Weight:
251.2272
MDL Number:
MFCD03094917
SMILES:
O=C(N1CC(C[C@H]1C(=O)O)(F)F)OC(C)(C)C
Properties
Properties
 
BP:
340.4°C at 760 mmHg  
Form:
Solid  
MP:
120-124°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
338  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.5  

Upstream Synthesis Route

[1]Patent:US2008/9497,2008,A1,.Locationinpatent:Page/Pagecolumn109

[2]Patent:WO2014/82379,2014,A1,.Locationinpatent:Page/Pagecolumn158;159;163

[3]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,#14,p.3859-3862

[1]Patent:WO2012/146666,2012,A1,.Locationinpatent:Page/Pagecolumn138-139

[2]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[3]Patent:WO2014/19344,2014,A1,.Locationinpatent:Paragraph00451

[4]Patent:WO2014/82380,2014,A1,.Locationinpatent:Paragraph00427;00430

[5]Patent:WO2014/82379,2014,A1,.Locationinpatent:Page/Pagecolumn158;159;161

[6]Patent:WO2014/131315,2014,A1,.Locationinpatent:Page/Pagecolumn124;125

[7]Patent:US2015/79028,2015,A1,.Locationinpatent:Paragraph1117;1124;1125;1126;1127

[8]Patent:CN103880823,2017,B,.Locationinpatent:Paragraph1612;1627;1628

[9]BioorganicandMedicinalChemistry,2006,vol.14,#8,p.2725-2746

[10]Patent:US2014/357650,2014,A1,.Locationinpatent:Paragraph0281;0290;0291;0292;0293

[11]Patent:WO2005/23762,2005,A1,.Locationinpatent:Page/Pagecolumn72

[12]Patent:EP1659121,2006,A1,.Locationinpatent:Page/Pagecolumn19-20

[13]Patent:WO2004/99185,2004,A1,.Locationinpatent:Page48

[14]Patent:US2005/131019,2005,A1,.Locationinpatent:Page/Pagecolumn31;34

[15]Patent:WO2013/107820,2013,A1,.Locationinpatent:Page/Pagecolumn45

[16]JournalofMedicinalChemistry,2014,vol.57,#7,p.3053-3074

[17]Patent:WO2015/28095,2015,A1,.Locationinpatent:Paragraph00222

[18]Patent:US2016/297830,2016,A1,.Locationinpatent:Paragraph0303

[1]BioorganicandMedicinalChemistry,2006,vol.14,#8,p.2725-2746

[2]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[3]Patent:WO2013/107820,2013,A1,

[4]Patent:WO2014/19344,2014,A1,

[5]JournalofMedicinalChemistry,2014,vol.57,#7,p.3053-3074

[6]Patent:WO2014/82380,2014,A1,

[7]Patent:WO2014/82379,2014,A1,

[8]Patent:WO2014/131315,2014,A1,

[9]Patent:US2014/357650,2014,A1,

[10]Patent:US2015/79028,2015,A1,

[11]Patent:CN103880823,2017,B,

[1]BioorganicandMedicinalChemistry,2006,vol.14,#8,p.2725-2746

[2]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[3]JournalofMedicinalChemistry,2014,vol.57,#7,p.3053-3074

[4]Patent:WO2014/131315,2014,A1,

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2006,vol.14,p.2725-2746

[1]BioorganicandMedicinalChemistry,2006,vol.14,p.6900-6916

[1]BioorganicandMedicinalChemistry,2006,vol.14,p.6900-6916

[1]Patent:US2011/82165,2011,A1.Locationinpatent:Page/Pagecolumn29-30

[2]ChemicalCommunications,2011,vol.47,p.10040-10042

[3]Patent:US2011/105520,2011,A1.Locationinpatent:Page/Pagecolumn36

[4]ChemMedChem,2015,vol.10,p.1071-1078

[5]Patent:WO2014/19344,2014,A1.Locationinpatent:Paragraph00452

[6]Patent:WO2014/131315,2014,A1.Locationinpatent:Page/Pagecolumn125

[7]Patent:US2015/79028,2015,A1.Locationinpatent:Paragraph1117;1128;1129;1130

[8]Patent:CN103880823,2017,B.Locationinpatent:Paragraph1612;1631;1632

[9]Patent:WO2013/152198,2013,A1.Locationinpatent:Paragraph00463;00464

[10]ChemicalandPharmaceuticalBulletin,2006,vol.54,p.1515-1529

[11]Patent:WO2011/88045,2011,A1.Locationinpatent:Page/Pagecolumn161

[12]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.5296-5300

[13]Patent:WO2015/109109,2015,A1

[14]Patent:US2017/44182,2017,A1

[1]ChemicalandPharmaceuticalBulletin,2006,vol.54,p.1515-1529

Literature
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SDS
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Tags:203866-15-3 Molecular Formula|203866-15-3 MDL|203866-15-3 SMILES|203866-15-3 N-Boc-4,4-difluoro-l-proline