Home Fluorides 69123-94-0
69123-94-0,MFCD00870798
Catalog No.:AA005XOW

69123-94-0 | 1-(2-Deoxy-2-fluoro-beta-d-arabinofuranosyl)uracil

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100mg
95%
in stock  
$17.00   $12.00
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250mg
95%
in stock  
$37.00   $26.00
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1g
95%
in stock  
$81.00   $57.00
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5g
95%
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$389.00   $272.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005XOW
Chemical Name:
1-(2-Deoxy-2-fluoro-beta-d-arabinofuranosyl)uracil
CAS Number:
69123-94-0
Molecular Formula:
C9H11FN2O5
Molecular Weight:
246.1924
MDL Number:
MFCD00870798
SMILES:
OC[C@H]1O[C@H]([C@H]([C@@H]1O)F)n1ccc(=O)[nH]c1=O
Properties
Properties
 
Form:
Solid  
MP:
162℃(Solv: chloroform (67-66-3); methanol (67-56-1))  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
374  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-1  

Literature

Title: Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging.

Journal: Nuclear medicine and biology 20111001

Title: The improved syntheses of 5-substituted 2'-[18F]fluoro-2'-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy.

Journal: Nuclear medicine and biology 20110701

Title: A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100901

Title: PET imaging of T cells derived from umbilical cord blood.

Journal: Leukemia 20090301

Title: Imaging of lymph node micrometastases using an oncolytic herpes virus and [F]FEAU PET.

Journal: PloS one 20090101

Title: Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU.

Journal: Molecular imaging 20090101

Title: Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080415

Title: Imaging of HSV-tk Reporter gene expression: comparison between [18F]FEAU, [18F]FFEAU, and other imaging probes.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080401

Title: Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20080101

Title: Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects.

Journal: Cancer research 20070401

Title: Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU.

Journal: Nature protocols 20070101

Title: 18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers.

Journal: Nuclear medicine communications 20060101

Title: Comparison of [14C]FMAU, [3H]FEAU, [14C]FIAU, and [3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20050101

Title: Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice.

Journal: Cancer research 20040901

Title: Inhibitory effects of 2'-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks.

Journal: Antimicrobial agents and chemotherapy 19900301

Title: Incorporation and metabolism of 2'-fluoro-5-substituted arabinosyl pyrimidines and their selective inhibition of viral DNA synthesis in herpes simplex virus type 1 (HSV-1)-infected and mock-infected Vero cells.

Journal: Antiviral research 19881201

Title: Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.

Journal: Antimicrobial agents and chemotherapy 19860101

Title: Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.

Journal: Journal of medicinal chemistry 19790101

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Tags:69123-94-0 Molecular Formula|69123-94-0 MDL|69123-94-0 SMILES|69123-94-0 1-(2-Deoxy-2-fluoro-beta-d-arabinofuranosyl)uracil |Heterocyclic_Building_Blocks