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195514-80-8,MFCD28167729
Catalog No.:AA00ABFU

195514-80-8 | AP20187

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1mg
≥95%
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$126.00   $88.00
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5mg
in stock  
$593.00   $415.00
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10mg
97%
in stock  
$941.00   $659.00
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25mg
97%
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$1,736.00   $1,215.00
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABFU
Chemical Name:
AP20187
CAS Number:
195514-80-8
Molecular Formula:
C82H107N5O20
Molecular Weight:
1482.7485
MDL Number:
MFCD28167729
SMILES:
CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@@H](c1cccc(c1)OCC(=O)NCC(CN(C)C)CNC(=O)COc1cccc(c1)[C@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@H](c1cc(OC)c(c(c1)OC)OC)CC)CCc1ccc(c(c1)OC)OC)CCc1ccc(c(c1)OC)OC)c1cc(OC)c(c(c1)OC)OC
Properties
Computed Properties
 
Complexity:
2450  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
107  
Hydrogen Bond Acceptor Count:
21  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
42  
XLogP3:
12.2  

Literature

Title: Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveals shared and distinct activities of holo and hybrid receptors.

Journal: The Journal of biological chemistry 20180309

Title: Targeting colorectal cancer stem cells with inducible caspase-9.

Journal: Apoptosis : an international journal on programmed cell death 20120501

Title: [The Yin and the Yang of senescence: is it possible to age without developing cancer?].

Journal: Medecine sciences : M/S 20120301

Title: Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.

Journal: Nature 20111102

Title: Long-term regulation of genetically modified primary hematopoietic cells in dogs.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20110701

Title: Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation.

Journal: The Journal of clinical investigation 20110601

Title: Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells.

Journal: Cancer research 20101201

Title: Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.

Journal: Journal of neuroimmunology 20100914

Title: Death switch for gene therapy: application to erythropoietin transgene expression.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20100701

Title: eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217

Title: Suppression of the intrinsic apoptosis pathway by synaptic activity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217

Title: Aggregation and amyloid fibril formation induced by chemical dimerization of recombinant prion protein in physiological-like conditions.

Journal: The Journal of biological chemistry 20091106

Title: A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth.

Journal: Journal of neuroscience research 20090901

Title: Chemically inducible inactivation of protein synthesis in genetically targeted neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527

Title: Controlled rod cell ablation in transgenic Xenopus laevis.

Journal: Investigative ophthalmology & visual science 20090201

Title: Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells.

Journal: Cancer gene therapy 20081001

Title: PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation.

Journal: Diabetes 20080801

Title: Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl.

Journal: Blood 20080415

Title: Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model.

Journal: Lab animal 20080101

Title: Constitutive and AP20187-induced Ret activation in photoreceptors does not protect from light-induced damage.

Journal: Investigative ophthalmology & visual science 20071101

Title: Selective control of endothelial cell proliferation with a synthetic dimerizer of FGF receptor-1.

Journal: Laboratory investigation; a journal of technical methods and pathology 20070801

Title: Aggregation of cellular prion protein is initiated by proximity-induced dimerization.

Journal: Journal of neurochemistry 20070801

Title: AP20187-mediated activation of a chimeric insulin receptor results in insulin-like actions in skeletal muscle and liver of diabetic mice.

Journal: Human gene therapy 20070201

Title: The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway.

Journal: Journal of cell science 20060801

Title: Development of peritoneal adhesions in macrophage depleted mice.

Journal: The Journal of surgical research 20060401

Title: Establishment of a cell model based on FKBP12 dimerization for screening of FK506-like neurotrophic small molecular compounds.

Journal: Journal of biomolecular screening 20060401

Title: Establishment of cell lines that exhibit correct ontogenic stage-specific gene expression profiles from tissues of yeast artificial chromosome transgenic mice using chemically induced growth signals.

Journal: Methods in molecular biology (Clifton, N.J.) 20060101

Title: Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling.

Journal: Molecular endocrinology (Baltimore, Md.) 20051101

Title: Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051001

Title: Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy.

Journal: Nature medicine 20050701

Title: Dimer formation of receptor activator of nuclear factor kappaB induces incomplete osteoclast formation.

Journal: Biochemical and biophysical research communications 20041203

Title: Pharmacological regulation of the insulin receptor signaling pathway mimics insulin action in cells transduced with viral vectors.

Journal: Human gene therapy 20041101

Title: Differences in F36VMpl-based in vivo selection among large animal models.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20041001

Title: In vivo selection of genetically modified erythroid cells using a jak2-based cell growth switch.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20040901

Title: [Promotion of in vitro long term expansion of primitive multipotential hematopoietic cells by transduced JAK2 gene].

Journal: Zhonghua yi xue za zhi 20040602

Title: Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene.

Journal: Journal of leukocyte biology 20040401

Title: [Long term regulated expansion and committed differentiation of JAK2 gene transfected hematopoietic stem/progenitor cells in vitro].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20040201

Title: Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2.

Journal: The EMBO journal 20040114

Title: Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion.

Journal: Journal of thrombosis and haemostasis : JTH 20030601

Title: Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.

Journal: FEBS letters 20030410

Title: An inducible system for the study of FGF signalling in early amphibian development.

Journal: Developmental biology 20030401

Title: Activation of procaspases by FK506 binding protein-mediated oligomerization.

Journal: Science's STKE : signal transduction knowledge environment 20030128

Title: Small-molecule-directed mpl signaling can complement growth factors to selectively expand genetically modified cord blood cells.

Journal: Stem cells (Dayton, Ohio) 20030101

Title: Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice.

Journal: Nature biotechnology 20021201

Title: Pharmacologically regulated in vivo selection in a large animal.

Journal: Blood 20020915

Title: Ablation of microvessels in vivo upon dimerization of iCaspase-9.

Journal: Gene therapy 20020401

Title: Dimerizer-induced proliferation of genetically modified hepatocytes.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20020401

Title: Ahmed S, et al. Photocleavable dimerizer for the rapid reversal of molecular trap antagonists. J Biol Chem. 2014 Feb 21;289(8):4546-52.

Title: Lin W, et al. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci. 2013 Apr 3;33(14):5980-91.

Title: Haas ME, et al. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 5;134(1):61-72.

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Tags:195514-80-8 Molecular Formula|195514-80-8 MDL|195514-80-8 SMILES|195514-80-8 AP20187