Home Other Building Blocks 1445379-92-9
1445379-92-9,MFCD28902237
Catalog No.:AA00ABO6

1445379-92-9 | Als-8112

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
1 week  
$336.00   $235.00
- +
5mg
99%
1 week  
$717.00   $502.00
- +
10mg
99%
1 week  
$1,003.00   $702.00
- +
50mg
99%
1 week  
$2,908.00   $2,035.00
- +
100mg
99%
1 week  
$4,050.00   $2,835.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABO6
Chemical Name:
Als-8112
CAS Number:
1445379-92-9
Molecular Formula:
C10H13ClFN3O4
Molecular Weight:
293.6793
MDL Number:
MFCD28902237
SMILES:
OC[C@@]1(CCl)O[C@H]([C@@H]([C@@H]1O)F)n1ccc(nc1=O)N
Properties
Computed Properties
 
Complexity:
447  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
-1.2  

Literature

Title: Wang G, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78.

Title: Jordan PC, et al. Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase. ACS Chem Biol. 2017 Jan 20;12(1):83-91.

Title: DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov 19;373(21):2048-58.

Title: Deval J, et al. Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate. PLoS Pathog. 2015 Jun 22;11(6):e1004995.

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SDS
Tags:1445379-92-9 Molecular Formula|1445379-92-9 MDL|1445379-92-9 SMILES|1445379-92-9 Als-8112