Catalog No.:AA00ACE9

151804-77-2 | AC187

Name: Name:AC187
Brand: AABLOCKS
SKU: AA00ACE9
Availability: InStock
Rating: 90 (10 reviews)

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1mg

2 weeks

$411.00 $288.00

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5mg

2 weeks

$947.00 $663.00

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10mg

2 weeks

$1,483.00 $1,038.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA00ACE9

Chemical Name:

AC187

CAS Number:

151804-77-2

Molecular Formula:

C127H205N37O40

Molecular Weight:

2890.2105

MDL Number:

MFCD03093452

SMILES:

NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccc(cc1)O)[C@H](O)C)CC(=O)N)CO)[C@H](O)C)CC(=O)N)[C@H](O)C)CCCNC(=N)N)Cc1ccc(cc1)O)[C@H](O)C)CCC(=O)N)CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)C)CC(C)C)CCCCN)CC(C)C)CO)CCC(=O)N)CCC(=O)O)CC(C)C)Cc1nc[nH]c1

Properties

Computed Properties

Complexity:

6550

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

204

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

-13.2

Literature

Title: Adrenomedullin-2/intermedin induces cAMP accumulation in dissociated rat spinal cord cells: evidence for the existence of a distinct class of sites of action.

Journal: Journal of molecular neuroscience : MN 20080701

Title: Protective effects of amylin on reserpine-induced gastric damage in the rat.

Journal: Pharmacological research 20070701

Title: Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.

Journal: Regulatory peptides 20061210

Title: Effects of amylin on feeding of goldfish: interactions with CCK.

Journal: Regulatory peptides 20060115

Title: Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.

Journal: Molecular pharmacology 20050501

Title: Receptor pharmacology.

Journal: Advances in pharmacology (San Diego, Calif.) 20050101

Title: Amylin receptor blockade stimulates food intake in rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20040901

Title: Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040616

Title: Chronic infusion of the amylin antagonist AC 187 increases feeding in Zucker fa/fa rats but not in lean controls.

Journal: Physiology & behavior 20040501

Title: Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats.

Journal: Physiology & behavior 20040301

Title: Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects.

Journal: Journal of neurophysiology 20030601

Title: Amylin, released from the gastric fundus, stimulates somatostatin and thus inhibits histamine and acid secretion in mice.

Journal: Gastroenterology 20020701

Title: Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20011201

Title: Inhibition of central amylin signaling increases food intake and body adiposity in rats.

Journal: Endocrinology 20011101

Title: Jack H Jhamandas, et al. Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84.

Title: Bronislava R Gedulin, et al. Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul Pept. 2006 Dec 10;137(3):121-7.

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