Name: Name:AM2394
Brand: AABLOCKS
SKU: AA00AMEE
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00AMEE

Chemical Name: AM2394

CAS Number: 1442684-77-6

Molecular Formula: C22H25N5O4

Molecular Weight: 423.4650

MDL Number: MFCD30533320

SMILES: CNC(=O)Nc1ncc(c(c1)Oc1cncc(c1)C)c1ccc(nc1)OCC(O)(C)C

Properties

Complexity: 578

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 31

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.8

Downstream Synthesis Route

766-11-0

1442684-77-6

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

79674-65-0

1442684-77-6

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

1099665-67-4

1442684-77-6

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

CASUnavailable

1442670-83-8

1442684-77-6

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

34941-91-8

1442684-77-6

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

Literature fold

Title: Microcalorimetric study of the anaerobic growth of Escherichia coli: measurements of the affinity of whole cells for various energy substrates.

Journal: Journal of bacteriology19760101

Title: Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23;7(7):714-8.

1442684-77-6 | AM2394