Home Other Building Blocks 1442684-77-6
1442684-77-6,MFCD30533320
Catalog No.:AA00AMEE

1442684-77-6 | AM2394

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$17.00   $12.00
- +
5mg
98%
in stock  
$43.00   $30.00
- +
10mg
98%
in stock  
$63.00   $44.00
- +
25mg
98%
in stock  
$105.00   $74.00
- +
50mg
98%
in stock  
$178.00   $125.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AMEE
Chemical Name:
AM2394
CAS Number:
1442684-77-6
Molecular Formula:
C22H25N5O4
Molecular Weight:
423.4650
MDL Number:
MFCD30533320
SMILES:
CNC(=O)Nc1ncc(c(c1)Oc1cncc(c1)C)c1ccc(nc1)OCC(O)(C)C
Properties
Computed Properties
 
Complexity:
578  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
1.8  

Downstream Synthesis Route

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

CASUnavailable 
  1442670-83-8    1442684-77-6 

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

[1]Dransfield,PaulJ.;Pattaropong,Vatee;Lai,Sujen;Fu,Zice;Kohn,ToddJ.;Du,Xiaohui;Cheng,Alan;Xiong,Yumei;Komorowski,Renee;Jin,Lixia;Conn,Marion;Tien,Eric;DeWolf,WalterE.;Hinklin,RonaldJ.;Aicher,ThomasD.;Kraser,ChristopherF.;Boyd,StevenA.;Voegtli,WalterC.;Condroski,KevinR.;Veniant-Ellison,Murielle;Medina,JulioC.;Houze,Jonathan;Coward,Peter[ACSMedicinalChemistryLetters,2016,vol.7,#7,p.714-718]

Literature

Title: Microcalorimetric study of the anaerobic growth of Escherichia coli: measurements of the affinity of whole cells for various energy substrates.

Journal: Journal of bacteriology 19760101

Title: Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23;7(7):714-8.

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