Home Other Building Blocks 3486-66-6
3486-66-6,MFCD03792689
Catalog No.:AA00BXGB

3486-66-6 | Coptisine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
98%
1 week  
$69.00   $48.00
- +
25mg
98%
1 week  
$115.00   $81.00
- +
50mg
98%
1 week  
$188.00   $132.00
- +
100mg
98%
1 week  
$321.00   $225.00
- +
250mg
98%
1 week  
$546.00   $382.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BXGB
Chemical Name:
Coptisine
CAS Number:
3486-66-6
Molecular Formula:
C19H14NO4+
Molecular Weight:
320.3188
MDL Number:
MFCD03792689
SMILES:
C1Oc2c(O1)cc1c(c2)CC[n+]2c1cc1ccc3c(c1c2)OCO3
Properties
Computed Properties
 
Complexity:
502  
Covalently-Bonded Unit Count:
1  
Formal Charge:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
XLogP3:
3.5  

Downstream Synthesis Route

[1]Chemicalandpharmaceuticalbulletin,1982,vol.30,p.3446-3449

[1]Hanaoka,Miyoji;Sakurai,Shun-ichiro;Ohshima,Takeshi;Yasuda,Shingo;Mukai,Chisato[Chemicalandpharmaceuticalbulletin,1982,vol.30,#9,p.3446-3449]

[1]Hanaoka,Miyoji;Yoshida,Shuji;Annen,Masami;Mukai,Chisato[ChemistryLetters,1986,p.739-742]

[1]Hanaoka,Miyoji;Yoshida,Shuji;Annen,Masami;Mukai,Chisato[ChemistryLetters,1986,p.739-742]

Literature

Title: Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.

Title: He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.

Title: Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:3486-66-6 Molecular Formula|3486-66-6 MDL|3486-66-6 SMILES|3486-66-6 Coptisine