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465-11-2,MFCD01740822
Catalog No.:AA00DDXT

465-11-2 | Gamabufotalin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$597.00   $418.00
- +
10mg
98%
in stock  
$1,011.00   $708.00
- +
25mg
98%
in stock  
$2,204.00   $1,543.00
- +
50mg
98%
in stock  
$3,920.00   $2,744.00
- +
100mg
98%
in stock  
$7,009.00   $4,907.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DDXT
Chemical Name:
Gamabufotalin
CAS Number:
465-11-2
Molecular Formula:
C24H34O5
Molecular Weight:
402.5238
MDL Number:
MFCD01740822
SMILES:
O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2[C@H](O)C[C@]2([C@]1(O)CC[C@@H]2c1ccc(=O)oc1)C)C
NSC Number:
90384
Properties
Computed Properties
 
Complexity:
773  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
2  

Literature

Title: Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

Journal: Journal of natural products 20010901

Title: Yu Z, et al. Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells. Mol Cancer. 2014 Aug 31;13:203.

Title: Dong Y, et al. Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway. Apoptosis. 2011 Apr;16(4):394-403.

Title: Lan YL, et al. Gamabufotalin induces a negative feedback loop connecting ATP1A3 expression and the AQP4 pathway to promote temozolomide sensitivity in glioblastoma cells by targeting the amino acid Thr794. Cell Prolif. 2020;53(1):e12732.

Title: Tang N, et al. Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway. Oncotarget. 2016;7(3):3533-3547.

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SDS
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