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566-28-9,MFCD00010474
Catalog No.:AA00E9FN

566-28-9 | 7-KETOCHOLESTEROL

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5mg
≥98%
in stock  
$82.00   $57.00
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10mg
≥98%
in stock  
$153.00   $107.00
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50mg
≥98%
in stock  
$589.00   $412.00
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100mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E9FN
Chemical Name:
7-KETOCHOLESTEROL
CAS Number:
566-28-9
Molecular Formula:
C27H44O2
Molecular Weight:
400.6371
MDL Number:
MFCD00010474
SMILES:
CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2C(=O)C=C2[C@]1(C)CC[C@@H](C2)O)C)C
Properties
Properties
 
Form:
Solid  
MP:
158-162°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
663  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
7.5  

Literature

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Journal: Redox biology 20171001

Title: Quercetin-3-O-(2″-galloyl)-α-L-rhamnopyranoside attenuates cholesterol oxidation product-induced apoptosis by suppressing NF-κB-mediated cell death process in differentiated PC12 cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20150801

Title: The effect of oxidized cholesterol on barrier functions and IL-10 mRNA expression in human intestinal epithelium co-cultured with dendritic cells in the transwell system.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140701

Title: Effects of serotonin on expression of the LDL receptor family member LR11 and 7-ketocholesterol-induced apoptosis in human vascular smooth muscle cells.

Journal: Biochemical and biophysical research communications 20140418

Title: Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene.

Journal: Cardiovascular research 20140401

Title: Resveratrol counteracts inflammation in human M1 and M2 macrophages upon challenge with 7-oxo-cholesterol: potential therapeutic implications in atherosclerosis.

Journal: Oxidative medicine and cellular longevity 20140101

Title: Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-2 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130601

Title: Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy.

Journal: Diabetologia 20121101

Title: Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors.

Journal: Clinical chemistry 20121101

Title: Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase.

Journal: Nitric oxide : biology and chemistry 20121015

Title: Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo.

Journal: Journal of cellular and molecular medicine 20121001

Title: Macrophage oxysterols and their binding proteins: roles in atherosclerosis.

Journal: Current opinion in lipidology 20121001

Title: Increased resistance to oxysterol cytotoxicity in fibroblasts transfected with a lysosomally targeted Chromobacterium oxidase.

Journal: Biotechnology and bioengineering 20120901

Title: Evaluation of the cytotoxic effect of 7keto-stigmasterol and 7keto-cholesterol in human intestinal (Caco-2) cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

Title: Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain.

Journal: The international journal of neuropsychopharmacology 20120801

Title: Roles of 7-ketocholesterol on the homeostasis of intracellular cholesterol level.

Journal: Journal of cardiovascular pharmacology 20120801

Title: Cyanidin-3-O-β-glucoside induces oxysterol efflux from endothelial cells: role of liver X receptor alpha.

Journal: Atherosclerosis 20120801

Title: Thermo-induced vesicular dynamics of membranes containing cholesterol derivatives.

Journal: Lipids 20120801

Title: Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-κB.

Journal: Molecular human reproduction 20120701

Title: The role of oxysterols in control of endothelial stiffness.

Journal: Journal of lipid research 20120701

Title: Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells.

Journal: Investigative ophthalmology & visual science 20120701

Title: Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells.

Journal: Acta ophthalmologica 20120601

Title: 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.

Journal: Biochimica et biophysica acta 20120601

Title: Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis.

Journal: Biochemistry 20120508

Title: Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.

Journal: Biochimica et biophysica acta 20120401

Title: NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications.

Journal: Gut and liver 20120401

Title: Inhibition of cholesterol oxidation products (COPs) formation in emulsified porcine patties by phenolic-rich avocado (Persea americana Mill.) extracts.

Journal: Journal of agricultural and food chemistry 20120307

Title: Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control.

Journal: World journal of gastroenterology 20120307

Title: Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease.

Journal: Cell death and differentiation 20120301

Title: 7-ketocholesterol is not cytotoxic to U937 cells when incorporated into acetylated low density lipoprotein.

Journal: Lipids 20120301

Title: Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120301

Title: Does lycopene offer human LDL any protection against myeloperoxidase activity?

Journal: Molecular and cellular biochemistry 20120201

Title: Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress.

Journal: British journal of cancer 20120103

Title: Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme.

Journal: Journal of clinical biochemistry and nutrition 20120101

Title: Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases.

Journal: Journal of clinical biochemistry and nutrition 20120101

Title: Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages.

Journal: PloS one 20120101

Title: Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts.

Journal: PloS one 20120101

Title: The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events.

Journal: Frontiers in immunology 20120101

Title: Effects of hydroquinone on retinal and vascular cells in vitro.

Journal: Indian journal of ophthalmology 20120101

Title: Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.

Journal: Mediators of inflammation 20120101

Title: Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro.

Journal: PloS one 20120101

Title: Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display.

Journal: International journal of molecular sciences 20120101

Title: Spatial distribution of the pathways of cholesterol homeostasis in human retina.

Journal: PloS one 20120101

Title: Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity.

Journal: Journal of lipids 20120101

Title: Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability.

Journal: PloS one 20120101

Title: The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells.

Journal: PloS one 20120101

Title: Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order.

Journal: Traffic (Copenhagen, Denmark) 20111201

Title: Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.

Journal: Journal of lipid research 20111001

Title: Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage.

Journal: Chemico-biological interactions 20110930

Title: Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.

Journal: The Journal of biological chemistry 20110923

Title: Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.

Journal: Journal of medicinal chemistry 20110922

Title: α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes.

Journal: Chemistry and physics of lipids 20110901

Title: The effect of oxycholesterols on thermo-induced membrane dynamics.

Journal: Biochimica et biophysica acta 20110901

Title: 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.

Journal: Frontiers in neuroendocrinology 20110801

Title: Lipid and cholesterol oxidation in chicken meat are inhibited by sage but not by garlic.

Journal: Journal of food science 20110801

Title: Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis.

Journal: Journal of chromatography. A 20110715

Title: A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma.

Journal: Journal of lipid research 20110701

Title: Red and white wines inhibit cholesterol oxidation induced by free radicals.

Journal: Journal of agricultural and food chemistry 20110622

Title: Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols.

Journal: Biochemical and biophysical research communications 20110617

Title: Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?

Journal: Free radical biology & medicine 20110615

Title: Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.

Journal: The Journal of biological chemistry 20110610

Title: Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells.

Journal: Journal of lipid research 20110601

Title: Effect of high pressure processing on cholesterol oxidation products in vacuum packaged sliced dry-cured ham.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110601

Title: Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20110401

Title: Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20110301

Title: Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110301

Title: Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression.

Journal: The Journal of nutritional biochemistry 20110301

Title: Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome.

Journal: Cell death & disease 20110301

Title: The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy.

Journal: Diabetologia 20110201

Title: Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.

Journal: Placenta 20110201

Title: [Sterols of marine bryozoan Bugula neritina from the South China Sea].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110201

Title: Protective role of arzanol against lipid peroxidation in biological systems.

Journal: Chemistry and physics of lipids 20110101

Title: 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways.

Journal: Neurochemistry international 20110101

Title: Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited.

Journal: Journal of clinical biochemistry and nutrition 20110101

Title: CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site.

Journal: PloS one 20110101

Title: Lipid pathway alterations in Parkinson's disease primary visual cortex.

Journal: PloS one 20110101

Title: Mechanisms of oxysterol-induced carcinogenesis.

Journal: Lipids in health and disease 20110101

Title: Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule.

Journal: Neuropharmacology 20110101

Title: Methotrexate in atherogenesis and cholesterol metabolism.

Journal: Cholesterol 20110101

Title: Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors.

Journal: Nutricion hospitalaria 20110101

Title: Marine carotenoids: biological functions and commercial applications.

Journal: Marine drugs 20110101

Title: Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments.

Journal: Journal of ophthalmology 20110101

Title: Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia.

Journal: PloS one 20110101

Title: The Dynamics of Oxidized LDL during Atherogenesis.

Journal: Journal of lipids 20110101

Title: Lipids, lipoproteins, and age-related macular degeneration.

Journal: Journal of lipids 20110101

Title: Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.

Journal: PloS one 20110101

Title: Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1.

Journal: Lipids in health and disease 20110101

Title: Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome.

Journal: Neurologia i neurochirurgia polska 20110101

Title: Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy.

Journal: Scientific reports 20110101

Title: Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate.

Journal: Free radical biology & medicine 20101215

Title: 7-Ketocholesterol and 7-hydroxycholesterol in pork meat and its gravy thermally treated without additives and in the presence of onion and garlic.

Journal: Meat science 20101201

Title: 7-ketocholesterol inhibits Na,K-ATPase activity by decreasing expression of its α1-subunit and membrane fluidity in human endothelial cells.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20101109

Title: Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol.

Journal: European journal of nutrition 20101001

Title: 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation.

Journal: Investigative ophthalmology & visual science 20101001

Title: Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration.

Journal: Journal of lipid research 20101001

Title: Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101001

Title: Isolation and identification of two steroid compounds from Oviductus Ranae.

Journal: Natural product research 20101001

Title: Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.

Journal: Biochimica et biophysica acta 20100901

Title: 7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways.

Journal: Toxicology letters 20100816

Title: The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.

Journal: Neuroscience 20100811

Title: Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.

Journal: Biochemical and biophysical research communications 20100806

Title: Feeding goats on scrubby Mexican rangeland and pasteurization: influences on milk and artisan cheese quality.

Journal: Tropical animal health and production 20100801

Title: oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation.

Journal: American journal of physiology. Cell physiology 20100801

Title: Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.

Journal: Journal of periodontal research 20100801

Title: Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects.

Journal: Free radical biology & medicine 20100801

Title: High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells.

Journal: Molecular membrane biology 20100801

Title: Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100701

Title: Changes in brain cholesterol metabolome after excitotoxicity.

Journal: Molecular neurobiology 20100601

Title: Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes.

Journal: Chemistry and physics of lipids 20100601

Title: Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring.

Journal: Clinical science (London, England : 1979) 20100428

Title: Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100401

Title: Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process.

Journal: Neurochemical research 20100401

Title: Influence of the lung mechanical ventilation with injurious parameters on 7-ketocholesterol synthesis in Sus Scrofa.

Journal: BMB reports 20100401

Title: 7-ketocholesterol induces cell apoptosis by activation of nuclear factor kappa B in mouse macrophages.

Journal: Acta medica Okayama 20100401

Title: 7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells.

Journal: Journal of cellular physiology 20100301

Title: Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy.

Journal: Carcinogenesis 20100301

Title: Methionine sulfoxide reductase B2 is highly expressed in the retina and protects retinal pigmented epithelium cells from oxidative damage.

Journal: Experimental eye research 20100301

Title: Oxidative damage in Parkinson disease: Measurement using accurate biomarkers.

Journal: Free radical biology & medicine 20100215

Title: Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro.

Journal: Investigative ophthalmology & visual science 20100201

Title: Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages.

Journal: The Journal of nutritional biochemistry 20100101

Title: Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.

Journal: Biochimica et biophysica acta 20100101

Title: Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells.

Journal: International journal of nanomedicine 20100101

Title: The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.

Journal: BMC ophthalmology 20100101

Title: Induction of ER stress in macrophages of tuberculosis granulomas.

Journal: PloS one 20100101

Title: Integral kinetic model for studying quercetin degradation and oxidation as affected by cholesterol during heating.

Journal: International journal of molecular sciences 20100101

Title: Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice.

Journal: The Libyan journal of medicine 20100101

Title: Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies.

Journal: Biological research 20100101

Title: Medical bioremediation: a concept moving toward reality.

Journal: Rejuvenation research 20091201

Title: Analysis of the capture and influence of nanoparticles on the cytotoxic effects of 7-ketocholesterol on cardiac cells: investigation by flow cytometry and by dynamic and spectral imaging microscopy associated with factor analysis of medical image sequences.

Journal: Analytical and quantitative cytology and histology 20091201

Title: Determination of oxysterols in oxidatively modified low-density lipoprotein by semi-micro high-performance liquid chromatography with electrochemical detection.

Journal: Analytical biochemistry 20091015

Title: Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants.

Journal: Journal of agricultural and food chemistry 20091014

Title: Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis.

Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20091001

Title: [The apoptosis of mouse macrophage J774A.1 induced by oxysterol depend on NF-kappaB activation].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20091001

Title: Concentration of anti-7-ketocholesterol antibodies in patient sera after heart transplantation.

Journal: Transplantation proceedings 20091001

Title: Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.

Journal: Bulletin of experimental biology and medicine 20090901

Title: Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change.

Journal: Neurochemical research 20090801

Title: The local electric field within phospholipid membranes modulates the charge transfer reactions in reaction centres.

Journal: Biochimica et biophysica acta 20090801

Title: Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis.

Journal: Journal of atherosclerosis and thrombosis 20090801

Title: TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells.

Journal: Journal of cellular and molecular medicine 20090801

Title: OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.

Journal: Journal of lipid research 20090701

Title: Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.

Journal: Archives of biochemistry and biophysics 20090701

Title: Increase of cholesterol oxidation and decrease of PUFA as a result of thermal processing and storage in eggs enriched with n-3 fatty acids.

Journal: Journal of agricultural and food chemistry 20090610

Title: 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death.

Journal: The Journal of biological chemistry 20090605

Title: Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice.

Journal: Neurochemical research 20090601

Title: Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis.

Journal: Molecular aspects of medicine 20090601

Title: A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk.

Journal: European journal of nutrition 20090601

Title: Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury.

Journal: Neuroscience letters 20090522

Title: The retinal oxysterol pathway: a unifying hypothesis for the cause of age-related macular degeneration.

Journal: Current opinion in ophthalmology 20090501

Title: AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors.

Journal: Biochemical and biophysical research communications 20090403

Title: Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1.

Journal: Molecular and cellular endocrinology 20090325

Title: Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression.

Journal: Circulation research 20090213

Title: Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia.

Journal: Journal of lipid research 20090201

Title: Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux.

Journal: Journal of lipid research 20090201

Title: 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation.

Journal: Investigative ophthalmology & visual science 20090201

Title: Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.

Journal: The Journal of nutritional biochemistry 20090101

Title: 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells.

Journal: Journal of vascular research 20090101

Title: Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Journal: BMC medical genomics 20090101

Title: Medical bioremediation of age-related diseases.

Journal: Microbial cell factories 20090101

Title: Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism.

Journal: Photochemistry and photobiology 20090101

Title: 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells.

Journal: Toxicology and industrial health 20090101

Title: Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia.

Journal: Journal of biomedicine & biotechnology 20090101

Title: Plasma membrane rafts engaged in T cell signalling: new developments in an old concept.

Journal: Cell communication and signaling : CCS 20090101

Title: Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells.

Journal: PloS one 20090101

Title: 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type.

Journal: Endocrinology 20081201

Title: ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet.

Journal: The Journal of clinical investigation 20081103

Title: Microbial degradation of 7-ketocholesterol.

Journal: Biodegradation 20081101

Title: Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis.

Journal: Journal of lipid research 20081101

Title: Oxysterol as a marker of atherogenic dyslipidemia in adolescence.

Journal: The Journal of clinical endocrinology and metabolism 20081101

Title: Role of oxidative stress in adaptive responses in special reference to atherogenesis.

Journal: Journal of clinical biochemistry and nutrition 20081101

Title: Evaluation of cholesterol and lipid oxidation in raw and cooked minced beef stored under oxygen-enriched atmosphere.

Journal: Meat science 20081101

Title: Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation.

Journal: Chemistry and physics of lipids 20080901

Title: Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080901

Title: Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation.

Journal: Molecular cancer research : MCR 20080801

Title: Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols.

Journal: Biophysical journal 20080715

Title: Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells.

Journal: British journal of pharmacology 20080701

Title: Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20080701

Title: Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.

Journal: Cardiovascular research 20080601

Title: 7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells.

Journal: Journal of atherosclerosis and thrombosis 20080601

Title: Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture.

Journal: Journal of agricultural and food chemistry 20080528

Title: Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.

Journal: The Journal of biological chemistry 20080411

Title: A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein.

Journal: Atherosclerosis 20080401

Title: 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro.

Journal: Microvascular research 20080401

Title: Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus.

Journal: Diabetes research and clinical practice 20080401

Title: Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample.

Journal: Free radical biology & medicine 20080401

Title: Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine.

Journal: Biochemistry 20080304

Title: [Variance of expressions of extracellular matrix components and effects of anti-osteoporotic drugs on Mönckeberg's arteriosclerosis].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080301

Title: The protective role of carotenoids against 7-keto-cholesterol formation in solution.

Journal: Molecular and cellular biochemistry 20080201

Title: Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice.

Journal: Free radical biology & medicine 20080201

Title: Proteome profiling of embryo chick retina.

Journal: Proteome science 20080101

Title: UV laser mediated cell selective destruction by confocal microscopy.

Journal: Neural development 20080101

Title: Functional implications of plasma membrane condensation for T cell activation.

Journal: PloS one 20080101

Title: Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201

Title: Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans.

Journal: Brain research reviews 20071201

Title: Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome.

Journal: Circulation 20070911

Title: In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress.

Journal: Free radical biology & medicine 20070901

Title: Engineering away lysosomal junk: medical bioremediation.

Journal: Rejuvenation research 20070901

Title: Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070801

Title: Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi).

Journal: Lipids 20070701

Title: Oxysterols are substrates for cholesterol sulfotransferase.

Journal: Journal of lipid research 20070601

Title: Oxysterols: functional significance in fetal development and the maintenance of normal retinal function.

Journal: Current opinion in lipidology 20070601

Title: Mechanisms involved in chylomicron remnant lipid uptake by macrophages.

Journal: Biochemical Society transactions 20070601

Title: Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages.

Journal: Free radical biology & medicine 20070515

Title: Low density lipoprotein undergoes oxidation within lysosomes in cells.

Journal: Circulation research 20070511

Title: Effect of storage on cholesterol oxide formation and fatty acid alterations in egg powder.

Journal: Journal of agricultural and food chemistry 20070404

Title: Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition.

Journal: Brain research 20070316

Title: Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy.

Journal: Free radical biology & medicine 20070301

Title: Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine.

Journal: Metabolism: clinical and experimental 20070301

Title: Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells.

Journal: Investigative ophthalmology & visual science 20070301

Title: 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages.

Journal: Free radical research 20070301

Title: Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells.

Journal: Current eye research 20070301

Title: Immunosupportive therapies in aging.

Journal: Clinical interventions in aging 20070301

Title: Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus.

Journal: Diabetes/metabolism research and reviews 20070101

Title: Comparison of excitation and emission ratiometric fluorescence methods for quantifying the membrane dipole potential.

Journal: Biochimica et biophysica acta 20070101

Title: Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants.

Journal: Neurotoxicology 20070101

Title: Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers.

Journal: Neurochemical research 20070101

Title: Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Autophagy of vascular smooth muscle cells in atherosclerotic lesions.

Journal: Autophagy 20070101

Title: Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

Journal: PloS one 20070101

Title: Cytoprotective effect of polysaccharide isolated from different mushrooms against 7-ketocholesterol induced damage in mouse liver cell line (BNL CL. 2).

Journal: Nutrition research and practice 20070101

Title: 7-Ketocholesterol enhances 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20061201

Title: Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function.

Journal: International journal of molecular medicine 20061201

Title: Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.

Journal: Investigative ophthalmology & visual science 20061201

Title: Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells.

Journal: Analytical and quantitative cytology and histology 20061201

Title: Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins.

Journal: Journal of lipid research 20061101

Title: The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells.

Journal: Molecular and cellular biochemistry 20061101

Title: Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio.

Journal: Free radical biology & medicine 20061001

Title: Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells.

Journal: Journal of atherosclerosis and thrombosis 20061001

Title: Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species.

Journal: European journal of pharmacology 20060928

Title: Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects.

Journal: Free radical biology & medicine 20060915

Title: Enhanced lipid peroxidation in tourniquet-release mice.

Journal: Clinica chimica acta; international journal of clinical chemistry 20060901

Title: Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina.

Journal: Experimental eye research 20060801

Title: Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury.

Journal: Journal of neuropathology and experimental neurology 20060701

Title: Formation of cholesterol oxidation products in marinated foods during heating.

Journal: Journal of agricultural and food chemistry 20060628

Title: Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes.

Journal: Steroids 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions.

Journal: Free radical biology & medicine 20060501

Title: Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1.

Journal: Molecular and cellular endocrinology 20060327

Title: Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor.

Journal: Neuroreport 20060206

Title: Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages.

Journal: Bulletin of experimental biology and medicine 20060201

Title: Skeletal muscle and liver oxysterols during fasting and alcohol exposure.

Journal: Metabolism: clinical and experimental 20060101

Title: The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism.

Journal: Biochimie 20060101

Title: Sterol oxidation in meat- and fish-based homogenized baby foods containing vegetable oils.

Journal: Journal of AOAC International 20060101

Title: Early involvement of ROS overproduction in apoptosis induced by 7-ketocholesterol.

Journal: Antioxidants & redox signaling 20060101

Title: Different cytotoxic injuries induced by lysophosphatidylcholine and 7-ketocholesterol in mouse endothelial cells.

Journal: Endothelium : journal of endothelial cell research 20060101

Title: Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum.

Journal: The Kobe journal of medical sciences 20060101

Title: Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats.

Journal: Journal of agricultural and food chemistry 20051214

Title: High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20051201

Title: Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL.

Journal: Free radical research 20051201

Title: 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death.

Journal: Journal of molecular and cellular cardiology 20051101

Title: Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA.

Journal: Free radical research 20051101

Title: Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages.

Journal: Journal of lipid research 20050901

Title: TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol.

Journal: Biochemical and biophysical research communications 20050812

Title: The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I.

Journal: Biochemistry 20050802

Title: Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species.

Journal: Journal of molecular endocrinology 20050801

Title: Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages.

Journal: European journal of clinical investigation 20050801

Title: 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways.

Journal: The FEBS journal 20050601

Title: Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead.

Journal: Human & experimental toxicology 20050601

Title: Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues.

Journal: Toxicology letters 20050516

Title: Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050401

Title: 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionation.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20050401

Title: A new LC/APCI-MS method for the determination of cholesterol oxidation products in food.

Journal: Journal of chromatography. A 20050304

Title: Oxysterols increase in diabetic rats.

Journal: Free radical research 20050301

Title: Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols.

Journal: Cell biology and toxicology 20050301

Title: Relevance and mechanism of oxysterol stereospecifity in coronary artery disease.

Journal: Free radical biology & medicine 20050215

Title: Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis.

Journal: Journal of lipid research 20050201

Title: Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells.

Journal: Diabetologia 20050201

Title: Novel routes for metabolism of 7-ketocholesterol.

Journal: Rejuvenation research 20050101

Title: Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort.

Journal: Nephron. Clinical practice 20050101

Title: Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy.

Journal: BMC biotechnology 20050101

Title: Apoptosis induced by 7-ketocholesterol is enhanced in smooth muscle cells derived from OLETF rats.

Journal: Journal of atherosclerosis and thrombosis 20050101

Title: [Cholesterol oxidation products in fresh and frozen shrimps, raw and grilled].

Journal: Nutricion hospitalaria 20050101

Title: Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study.

Journal: Journal of biochemical and molecular toxicology 20050101

Title: Enhancement of MMP-9 activity in THP-1 cells by 7-ketocholesterol and its suppression by the HMG-CoA reductase inhibitor fluvastatin.

Journal: Journal of atherosclerosis and thrombosis 20050101

Title: 7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20041201

Title: Induction of the paraoxonase-1 gene expression by resveratrol.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20041201

Title: In vitro folate supplementation alleviates oxidative stress, mitochondria-associated death signalling and apoptosis induced by 7-ketocholesterol.

Journal: The British journal of nutrition 20041201

Title: FRET multiphoton spectral imaging microscopy of 7-ketocholesterol and Nile Red in U937 monocytic cells loaded with 7-ketocholesterol.

Journal: Analytical and quantitative cytology and histology 20041201

Title: Translocation of phospholipase A2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation.

Journal: Biochimica et biophysica acta 20041108

Title: 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling.

Journal: Cardiovascular research 20041001

Title: Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis.

Journal: Cell death and differentiation 20040801

Title: Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol.

Journal: Investigative ophthalmology & visual science 20040801

Title: Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.

Journal: The Journal of biological chemistry 20040723

Title: Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2.

Journal: The Biochemical journal 20040601

Title: The leaf extract of Ginkgo Biloba L. suppresses oxidized LDL-stimulated fibronectin production through an antioxidant action in rat mesangial cells.

Journal: British journal of pharmacology 20040601

Title: Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism.

Journal: Molecular and cellular biology 20040601

Title: Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.

Journal: The Journal of biological chemistry 20040430

Title: Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040401

Title: Oxysterols regulate expression of the steroidogenic acute regulatory protein.

Journal: Journal of molecular endocrinology 20040401

Title: Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.

Journal: Cellular and molecular life sciences : CMLS 20040401

Title: Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301

Title: Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells.

Journal: The Journal of steroid biochemistry and molecular biology 20040301

Title: Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function.

Journal: Biochemistry 20040203

Title: Analysis of the fluorescence of monodansylcadaverine-positive cytoplasmic structures during 7-ketocholesterol-induced cell death.

Journal: Analytical and quantitative cytology and histology 20040201

Title: AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis.

Journal: The Journal of biological chemistry 20040109

Title: Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040101

Title: Trojan horse-like behavior of a biologically representative mixture of oxysterols.

Journal: Molecular aspects of medicine 20040101

Title: Analysis of cholesterol oxidation products in biological samples.

Journal: Journal of AOAC International 20040101

Title: Comparison of cholesterol oxidation product preparation methods for subsequent gas chromatographic analysis.

Journal: Journal of AOAC International 20040101

Title: Cholesterol oxidation in meat-based baby foods.

Journal: Journal of AOAC International 20040101

Title: Cholesterol oxidation in intravenous lipid emulsions: safety of preparations before and after experimental hyperoxia.

Journal: JPEN. Journal of parenteral and enteral nutrition 20040101

Title: The inhibitory effect of alacepril, an angiotensin-converting enzyme inhibitor, on endothelial inflammatory response induced by oxysterol and TNF-alpha.

Journal: Redox report : communications in free radical research 20040101

Title: 7-Ketocholesterol enhances the expression of adhesion molecules on human aortic endothelial cells by increasing the production of reactive oxygen species.

Journal: Redox report : communications in free radical research 20040101

Title: Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases.

Journal: Experimental cell research 20031210

Title: Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL.

Journal: Biochemical and biophysical research communications 20031017

Title: Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture.

Journal: Biochemical pharmacology 20031015

Title: Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.

Journal: Free radical biology & medicine 20031015

Title: 7-ketocholesterol stimulates differentiation of lens epithelial cells.

Journal: Molecular vision 20031006

Title: Origin of oxysterols in hepatic bile of patients with biliary infection.

Journal: The American journal of gastroenterology 20031001

Title: Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams.

Journal: Journal of agricultural and food chemistry 20030910

Title: Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification.

Journal: Journal of lipid research 20030901

Title: Increase in cholesterol and cholesterol oxidation products, and role of cholesterol oxidation products in kainate-induced neuronal injury.

Journal: Brain pathology (Zurich, Switzerland) 20030701

Title: Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis.

Journal: The Journal of biological chemistry 20030606

Title: Oxysterol-induced toxicity in R28 and ARPE-19 cells.

Journal: Neurochemical research 20030601

Title: Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury.

Journal: Archives of toxicology 20030601

Title: Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030501

Title: Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate.

Journal: Biochemical and biophysical research communications 20030411

Title: Presence of phytosterol oxides in crude vegetable oils and their fate during refining.

Journal: Journal of agricultural and food chemistry 20030409

Title: Lipid peroxidation and vitamin E in human coronary atherosclerotic lesions.

Journal: Clinica chimica acta; international journal of clinical chemistry 20030401

Title: Chronology of cellular alterations during 7-ketocholesterol-induced cell death on A7R5 rat smooth muscle cells: analysis by time lapse-video microscopy and conventional fluorescence microscopy.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030401

Title: Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1.

Journal: The Journal of biological chemistry 20030328

Title: Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030301

Title: 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle.

Journal: Legal medicine (Tokyo, Japan) 20030301

Title: Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status.

Journal: Analytical biochemistry 20030115

Title: Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines.

Journal: British journal of cancer 20030113

Title: Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation.

Journal: European journal of pharmacology 20021205

Title: Flow cytometry and factor analysis evaluation of confocal image sequences of morphologic and functional changes occurring at the mitochondrial level during 7-ketocholesterol-induced cell death.

Journal: Analytical and quantitative cytology and histology 20021201

Title: Prevention of LDL alpha-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine.

Journal: Atherosclerosis 20021101

Title: The impairment of endothelium-dependent arterial relaxation by 7-ketocholesterol is associated with an early activation of protein kinase C.

Journal: British journal of pharmacology 20021101

Title: Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20021101

Title: Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat.

Journal: Journal of agricultural and food chemistry 20021009

Title: Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis.

Journal: The British journal of nutrition 20021001

Title: 7-ketocholesterol in human and adapted milk formulas.

Journal: Clinical nutrition (Edinburgh, Scotland) 20021001

Title: Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages.

Journal: Journal of lipid research 20020901

Title: Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions.

Journal: International journal of food sciences and nutrition 20020901

Title: Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals.

Journal: Biochemical pharmacology 20020801

Title: Active labour is associated with increased oxidisibility of serum lipids ex vivo.

Journal: BJOG : an international journal of obstetrics and gynaecology 20020801

Title: A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken.

Journal: Steroids 20020701

Title: Effect of oxysterols on hematopoietic progenitor cells.

Journal: Experimental hematology 20020701

Title: 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells.

Journal: Archives of biochemistry and biophysics 20020615

Title: Chronic ethanol feeding increases 7-hydroperoxycholesterol and oxysterols in rat skeletal muscle.

Journal: Metabolism: clinical and experimental 20020601

Title: Effect of chronic ethanol feeding on oxysterols in rat liver.

Journal: Free radical research 20020601

Title: [Characterization of the lipid portion of pink shrimp commercial samples].

Journal: Archivos latinoamericanos de nutricion 20020601

Title: Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro.

Journal: Experimental & molecular medicine 20020531

Title: Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters.

Journal: The British journal of nutrition 20020501

Title: Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice.

Journal: Biochimica et biophysica acta 20020415

Title: Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats.

Journal: Bioscience, biotechnology, and biochemistry 20020401

Title: Oxidized lipoproteins and macrophages.

Journal: Vascular pharmacology 20020401

Title: Oxysterols as indices of oxidative stress in man after paraquat ingestion.

Journal: Free radical research 20020201

Title: [Assessment of plasma lipid profile oxysterols and vitamin E concentration in morbidity obese patients with coexisting arterial hypertension and non-insulin dependent diabetes mellitus].

Journal: Polskie Archiwum Medycyny Wewnetrznej 20020201

Title: Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol.

Journal: Journal of lipid research 20020101

Title: [Effect of modified low density lipoproteins on humoral immune response and functional activity of macrophages in mice].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20020101

Title: Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells.

Journal: Journal of atherosclerosis and thrombosis 20020101

Title: Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin.

Journal: Journal of atherosclerosis and thrombosis 20020101

Title: [Concentration of the oxygenated derivates of cholesterol in pregnant women suffering from diabetes type I].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20020101

Title: Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation.

Journal: Atherosclerosis 20011201

Title: Oxidized low density lipoprotein inhibits prostacyclin generation by rat aorta in vitro: a key role of lysolecithin.

Journal: Prostaglandins & other lipid mediators 20011201

Title: Interaction of caveolin with 7-ketocholesterol.

Journal: Atherosclerosis 20011101

Title: 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells.

Journal: Atherosclerosis 20011101

Title: Oxidation process affecting fatty acids and cholesterol in fried and roasted salmon.

Journal: Journal of agricultural and food chemistry 20011101

Title: Inhibition of cholesterol efflux by 7-ketocholesterol: comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors.

Journal: Biochemistry 20011030

Title: Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20011001

Title: 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages.

Journal: Atherosclerosis 20010901

Title: Nephrotic origin hyperlipidemia, relative reduction of vitamin E level and subsequent oxidative stress may promote atherosclerosis.

Journal: Nephron 20010901

Title: Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells.

Journal: The Journal of biological chemistry 20010824

Title: A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1.

Journal: Biochemistry 20010807

Title: Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients.

Journal: QJM : monthly journal of the Association of Physicians 20010801

Title: Cholesterol oxidation products in irradiated raw meat with different packaging and storage time.

Journal: Meat science 20010801

Title: Up-regulation of the fibrogenic cytokine TGF-beta1 by oxysterols: a mechanistic link between cholesterol and atherosclerosis.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010701

Title: Fatty acid modifications and cholesterol oxidation in pork loin during frying at different temperatures.

Journal: Journal of food protection 20010701

Title: Effects of oxygenated sterol on phospholipid bilayer properties: a molecular dynamics simulation.

Journal: Chemistry and physics of lipids 20010701

Title: Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells.

Journal: Lipids 20010701

Title: Oxysterol profiles of normal human arteries, fatty streaks and advanced lesions.

Journal: Free radical research 20010701

Title: Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis.

Journal: Steroids 20010601

Title: Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina.

Journal: The Journal of biological chemistry 20010525

Title: Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I.

Journal: The Journal of biological chemistry 20010511

Title: An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture.

Journal: Biochimica et biophysica acta 20010430

Title: Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL.

Journal: The Biochemical journal 20010401

Title: Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis.

Journal: Clinica chimica acta; international journal of clinical chemistry 20010401

Title: Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010401

Title: Effect of irradiation and packaging conditions after cooking on the formation of cholesterol and lipid oxidation products in meats during storage.

Journal: Meat science 20010401

Title: 7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta.

Journal: Biochimica et biophysica acta 20010226

Title: 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor.

Journal: The Journal of biological chemistry 20010202

Title: Confocal analysis of phosphatidylserine externalization with the use of biotinylated annexin V revealed with streptavidin-FITC, -europium, -phycoerythrin or -Texas Red in oxysterol-treated apoptotic cells.

Journal: Analytical and quantitative cytology and histology 20010201

Title: Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage.

Journal: Poultry science 20010101

Title: Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death.

Journal: Cell death and differentiation 20010101

Title: Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols.

Journal: Cell biology and toxicology 20010101

Title: Plasma levels of soluble vascular adhesion molecule-1 and cholesterol oxidation product in type 2 diabetic patients with nephropathy.

Journal: Journal of atherosclerosis and thrombosis 20010101

Title: 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A).

Journal: Journal of lipid research 20001001

Title: Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture.

Journal: The Journal of biological chemistry 20000908

Title: Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver.

Journal: Atherosclerosis 19970601

Title: Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis.

Journal: Journal of lipid research 19950201

Title: Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro.

Journal: European journal of biochemistry 19750616

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Tags:566-28-9 Molecular Formula|566-28-9 MDL|566-28-9 SMILES|566-28-9 7-KETOCHOLESTEROL